Phytoene Desaturase (neurosporene-forming)
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Phytoene Desaturase (neurosporene-forming)
Phytoene desaturase (neurosporene-forming) (, ''3-step phytoene desaturase'', ''three-step phytoene desaturase'', ''phytoene desaturase (ambiguous)'', ''CrtI (ambiguous)'') is an enzyme with systematic name ''15-cis-phytoene:acceptor oxidoreductase (neurosporene-forming)''. This enzyme catalyses the following chemical reaction : 15-''cis''-phytoene + 3 acceptor \rightleftharpoons all-''trans''-neurosporene + 3 reduced acceptor (overall reaction) : (1a) 15-''cis''-phytoene + acceptor \rightleftharpoons all-''trans''-phytofluene + reduced acceptor : (1b) all-''trans''-phytofluene + acceptor \rightleftharpoons all-''trans''-''zeta''-carotene + reduced acceptor : (1c) all-''trans''-''zeta''-carotene + acceptor \rightleftharpoons all-''trans''-neurosporene + reduced acceptor This enzyme is involved in carotenoid biosynthesis. See also * Phytoene desaturase (lycopene-forming) * 15-Cis-phytoene desaturase * Phytoene desaturase (zeta-carotene-forming) Phytoene desaturase (zeta-ca ...
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Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ...
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List Of Enzymes
This article lists enzymes by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission (EC) numbering system. * List of EC numbers (EC 5) * List of EC numbers (EC 6) :Oxidoreductases (EC 1) (Oxidoreductase) *Dehydrogenase * Luciferase *DMSO reductase :EC 1.1 (act on the CH-OH group of donors) * :EC 1.1.1 (with NAD+ or NADP+ as acceptor) ** Alcohol dehydrogenase (NAD) ** Alcohol dehydrogenase (NADP) **Homoserine dehydrogenase ** Aminopropanol oxidoreductase **Diacetyl reductase **Glycerol dehydrogenase **Propanediol-phosphate dehydrogenase ** glycerol-3-phosphate dehydrogenase (NAD+) ** D-xylulose reductase **L-xylulose reductase **Lactate dehydrogenase **Malate dehydrogenase **Isocitrate dehydrogenase ** HMG-CoA reductase * :EC 1.1.2 (with a cytochrome as acceptor) * :EC 1.1.3 (with oxygen as acceptor) **Glucose oxidase **L-gulonolactone oxidase **Thiamine oxidase **Xanthine oxidase * :EC 1.1.4 (with a disul ...
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Catalysis
Catalysis () is the process of increasing the rate of a chemical reaction by adding a substance known as a catalyst (). Catalysts are not consumed in the reaction and remain unchanged after it. If the reaction is rapid and the catalyst recycles quickly, very small amounts of catalyst often suffice; mixing, surface area, and temperature are important factors in reaction rate. Catalysts generally react with one or more reactants to form intermediates that subsequently give the final reaction product, in the process of regenerating the catalyst. Catalysis may be classified as either homogeneous, whose components are dispersed in the same phase (usually gaseous or liquid) as the reactant, or heterogeneous, whose components are not in the same phase. Enzymes and other biocatalysts are often considered as a third category. Catalysis is ubiquitous in chemical industry of all kinds. Estimates are that 90% of all commercially produced chemical products involve catalysts at some s ...
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Chemical Reaction
A chemical reaction is a process that leads to the IUPAC nomenclature for organic transformations, chemical transformation of one set of chemical substances to another. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and breaking of chemical bonds between atoms, with no change to the Atomic nucleus, nuclei (no change to the elements present), and can often be described by a chemical equation. Nuclear chemistry is a sub-discipline of chemistry that involves the chemical reactions of unstable and radioactive Chemical element, elements where both electronic and nuclear changes can occur. The substance (or substances) initially involved in a chemical reaction are called reagent, reactants or reagents. Chemical reactions are usually characterized by a chemical change, and they yield one or more Product (chemistry), products, which usually have properties different from the reactants. Reactions often consist of a sequence o ...
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Phytoene
Phytoene () is a 40-carbon intermediate in the biosynthesis of carotenoids. The synthesis of phytoene is the first committed step in the synthesis of carotenoids in plants. Phytoene is produced from two molecules of geranylgeranyl pyrophosphate (GGPP) by the action of the enzyme phytoene synthase. The two GGPP molecules are condensed together followed by removal of diphosphate and proton shift leading to the formation of phytoene. Dietary phytoene and phytofluene are found in a number of human tissues including the liver, lung, breast, prostate, colon, and skin. Accumulation of these carotenoids in the skin may protect the skin by several mechanisms: acting as UV absorbers, as antioxidants, and as anti-inflammatory agents. Structure Phytoene is a symmetric molecule containing three conjugated double bonds. Phytoene has a UV-Vis absorption spectrum ''typical'' for a triply conjugated system with its main absorption maximum in the UVB range at 286 nm and with '' ε1% of 915 ...
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Neurosporene
Neurosporene is a carotenoid pigment. It is an intermediate in the biosynthesis of lycopene Lycopene is an organic compound classified as a tetraterpene and a carotene. Lycopene (from the neo-Latin ''Lycopersicum'', the tomato species) is a bright red carotenoid hydrocarbon found in tomatoes and other red fruits and vegetables. Occu ... and a variety of bacterial carotenoids. References Carotenoids {{organic-compound-stub ...
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Phytofluene
Phytofluene is a colorless carotenoid found naturally in tomatoes and other vegetables. It is the second product of carotenoid biosynthesis. It is formed from phytoene in a desaturation reaction leading to the formation of five conjugated double bonds. In the following step, addition of carbon-carbon conjugated double bonds leads to the formation of z-carotene and appearance of visible color. Phytofluene has an absorption spectra in the UVA range, with maximal absorption at 348 nm and with ε1% of 1557. Analysis of several fruits and vegetables showed that phytoene and phytofluene are found in majority of fruits and vegetables. In contrast to all other carotenoids, phytoene Phytoene () is a 40-carbon intermediate in the biosynthesis of carotenoids. The synthesis of phytoene is the first committed step in the synthesis of carotenoids in plants. Phytoene is produced from two molecules of geranylgeranyl pyrophosphate (G ... and phytofluene, the first carotenoid precursors i ...
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Carotenoid
Carotenoids (), also called tetraterpenoids, are yellow, orange, and red organic compound, organic pigments that are produced by plants and algae, as well as several bacteria, and Fungus, fungi. Carotenoids give the characteristic color to pumpkins, carrots, parsnips, maize, corn, tomatoes, Domestic Canary, canaries, flamingos, salmon, lobster, shrimp, and daffodils. Carotenoids can be produced from Lipid, fats and other basic organic metabolic building blocks by all these organisms. It is also produced by Endosymbiont, endosymbiotic bacteria in Whitefly, whiteflies. Carotenoids from the diet are stored in the fatty tissues of animals, and exclusively Carnivore, carnivorous animals obtain the compounds from animal fat. In the human diet, Small intestine#Absorption, absorption of carotenoids is improved when consumed with fat in a meal. Cooking carotenoid-containing vegetables in oil and shredding the vegetable both increase carotenoid bioavailability. There are over 1,100 known c ...
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Phytoene Desaturase (lycopene-forming)
Phytoene desaturase (lycopene-forming) (CrtI, ''four-step phytoene desaturase'') (, ''15-cis-phytoene:acceptor oxidoreductase (lycopene-forming)'') are enzymes found in archaea, bacteria and fungi that are involved in carotenoid biosynthesis. They catalyze the conversion of colorless 15-''cis''-phytoene into a bright red lycopene in a biochemical pathway called the poly-trans pathway. The same process in plants and cyanobacteria utilizes four separate enzymes in a poly-''cis'' pathway. Biochemistry Bacterial phytoene desaturases were shown to require FAD as a cofactor for their function. During the chemical reaction in total four additional double bonds are introduced into phytoene: : 15-''cis''-phytoene + 4 acceptor \rightleftharpoons all-''trans''-lycopene + 4 reduced acceptor (overall reaction) : (1a) 15-''cis''-phytoene + acceptor \rightleftharpoons all-''trans''-phytofluene + reduced acceptor : (1b) all-''trans''-phytofluene + acceptor \rightleftharpoons all-''trans''-' ...
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15-Cis-phytoene Desaturase
15-''cis''-phytoene desaturases (''PDS'', ''plant-type phytoene desaturases'') (, ''15-cis-phytoene:plastoquinone oxidoreductase''), are enzymes involved in the carotenoid biosynthesis in plants and cyanobacteria. Phytoene desaturases are membrane-bound enzymes localized in plastids and introduce two double bonds into their colorless substrate phytoene by dehydrogenation and isomerize two additional double bonds. This reaction starts a biochemical pathway involving three further enzymes ( zeta-carotene isomerase, zeta-carotene desaturase and carotene cis-trans isomerase) called the poly-cis pathway and leads to the red colored lycopene. The homologous phytoene desaturase found in bacteria and fungi ( CrtI) converts phytoene directly to lycopene by an all-trans pathway. Biochemistry PDS converts 15-''cis''-phytoene into 9,15,9'-tri-''cis''-ζ-carotene through reduction of the enzymes non-covalently bound FAD cofactor. This conversion introduces two additional double bonds at p ...
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Phytoene Desaturase (zeta-carotene-forming)
Phytoene desaturase (zeta-carotene-forming) (, ''CrtIa'', ''2-step phytoene desaturase (ambiguous)'', ''two-step phytoene desaturase (ambiguous)'') is an enzyme with systematic name ''15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming)''. This enzyme catalyses the following chemical reaction : 15-cis-phytoene + 2 acceptor \rightleftharpoons all-trans-zeta-carotene + 2 reduced acceptor (overall reaction) : (1a) 15-cis-phytoene + acceptor \rightleftharpoons all-trans-phytofluene + reduced acceptor : (1b) all-trans-phytofluene + acceptor \rightleftharpoons all-trans-zeta-carotene + reduced acceptor The enzyme is involved in carotenoid biosynthesis. See also * Phytoene desaturase (lycopene-forming) * Phytoene desaturase (neurosporene-forming) * 15-Cis-phytoene desaturase 15-''cis''-phytoene desaturases (''PDS'', ''plant-type phytoene desaturases'') (, ''15-cis-phytoene:plastoquinone oxidoreductase''), are enzymes involved in the carotenoid biosynthesis in plants and ...
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