Photon Diffusion Equation
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Photon Diffusion Equation
Photon diffusion equation is a second order partial differential equation describing the time behavior of photon fluence rate distribution in a low-absorption high-scattering medium. Its mathematical form is as follows. \nabla(D(r)\cdot\nabla)\Phi(\vec,t)-v\mu_a(\vec)\Phi(\vec,t)+vS(\vec,t)=\frac{\partial t} where \Phi is photon fluence rate (W/cm2), \nabla is del operator, \mu_a is absorption coefficient (cm−1), D is diffusion constant Fick's laws of diffusion describe diffusion and were derived by Adolf Fick in 1855. They can be used to solve for the diffusion coefficient, . Fick's first law can be used to derive his second law which in turn is identical to the diffusion equ ..., v is the speed of light in the medium (m/s), and S is an isotropic source term (W/cm3). Its main difference with diffusion equation in physics is that photon diffusion equation has an absorption term in it. Application Medical Imaging The properties of photon diffusion as explained by the equa ...
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Partial Differential Equation
In mathematics, a partial differential equation (PDE) is an equation which imposes relations between the various partial derivatives of a Multivariable calculus, multivariable function. The function is often thought of as an "unknown" to be solved for, similarly to how is thought of as an unknown number to be solved for in an algebraic equation like . However, it is usually impossible to write down explicit formulas for solutions of partial differential equations. There is, correspondingly, a vast amount of modern mathematical and scientific research on methods to Numerical methods for partial differential equations, numerically approximate solutions of certain partial differential equations using computers. Partial differential equations also occupy a large sector of pure mathematics, pure mathematical research, in which the usual questions are, broadly speaking, on the identification of general qualitative features of solutions of various partial differential equations, such a ...
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Fluence Rate
In radiometry, radiant exposure or fluence is the radiant energy ''received'' by a ''surface'' per unit area, or equivalently the irradiance of a ''surface,'' integrated over time of irradiation, and spectral exposure is the radiant exposure per unit frequency or wavelength, depending on whether the spectrum is taken as a function of frequency or of wavelength. The SI unit of radiant exposure is the joule per square metre (), while that of spectral exposure in frequency is the joule per square metre per hertz () and that of spectral exposure in wavelength is the joule per square metre per metre ()—commonly the joule per square metre per nanometre (). Mathematical definitions Radiant exposure Radiant exposure of a ''surface'', denoted ''H''e ("e" for "energetic", to avoid confusion with photometric quantities), is defined as H_\mathrm = \frac = \int_0^T E_\mathrm(t)\, \mathrmt, where *∂ is the partial derivative symbol; *''Q''e is the radiant energy; *''A'' is the area; *''T'' i ...
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Diffusion Constant
Fick's laws of diffusion describe diffusion and were derived by Adolf Fick in 1855. They can be used to solve for the diffusion coefficient, . Fick's first law can be used to derive his second law which in turn is identical to the diffusion equation. A diffusion process that obeys Fick's laws is called normal or Fickian diffusion; otherwise, it is called anomalous diffusion or non-Fickian diffusion. History In 1855, physiologist Adolf Fick first reported* * his now well-known laws governing the transport of mass through diffusive means. Fick's work was inspired by the earlier experiments of Thomas Graham, which fell short of proposing the fundamental laws for which Fick would become famous. Fick's law is analogous to the relationships discovered at the same epoch by other eminent scientists: Darcy's law (hydraulic flow), Ohm's law (charge transport), and Fourier's Law (heat transport). Fick's experiments (modeled on Graham's) dealt with measuring the concentrations and f ...
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Diffusion Equation
The diffusion equation is a parabolic partial differential equation. In physics, it describes the macroscopic behavior of many micro-particles in Brownian motion, resulting from the random movements and collisions of the particles (see Fick's laws of diffusion). In mathematics, it is related to Markov processes, such as random walks, and applied in many other fields, such as materials science, information theory, and biophysics. The diffusion equation is a special case of the convection–diffusion equation, when bulk velocity is zero. It is equivalent to the heat equation under some circumstances. Statement The equation is usually written as: where is the density of the diffusing material at location and time and is the collective diffusion coefficient for density at location ; and represents the vector differential operator del. If the diffusion coefficient depends on the density then the equation is nonlinear, otherwise it is linear. The equation above applies wh ...
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Diffuse Optical Tomography
Diffuse optical imaging (DOI) is a method of imaging using near-infrared spectroscopy (NIRS) or fluorescence-based methods. When used to create 3D volumetric models of the imaged material DOI is referred to as diffuse optical tomography, whereas 2D imaging methods are classified as diffuse optical imaging. The technique has many applications to neuroscience, sports medicine, wound monitoring, and cancer detection. Typically DOI techniques monitor changes in concentrations of oxygenated and deoxygenated hemoglobin and may additionally measure redox states of cytochromes. The technique may also be referred to as diffuse optical tomography (DOT), near infrared optical tomography (NIROT) or fluorescence diffuse optical tomography (FDOT), depending on the usage. In neuroscience, functional measurements made using NIR wavelengths, DOI techniques may classify as functional near infrared spectroscopy fNIRS. Physical mechanism Biological tissues can be considered strongly diffusive me ...
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