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Pemphigus Vegetans
Pemphigus vegetans is a localized form of pemphigus vulgaris. in which there is a localized vegetating papillomatous response. The eroded areas do not heal like usual but form papillomatous growth and vegetation. Accounts for 1-2% of pemphigus cases and is a relatively benign variant of pemphigus vulgaris. Two forms are recognized: * ''Pemphigus vegetans of Neumann'' is a localized disease of pemphigus vulgaris slightly more extensive than pemphigus vegetans of Hallopeau. This type is more common and characterized by early lesions similar to Pemphigus Vulgaris with large bullae and erosive areas. Healing is through formation of granulation tissue. It is named for the Austrian Dermatologist, Isidor Neumann. * ''Pemphigus vegetans of Hallopeau'' is a disease of localized pemphigus vulgaris. It is named for François Henri Hallopeau. This type is less aggressive and has pustules not bullae. These pustules heal by verrucous hyperkeratotic vegetations. See also * List of cutane ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pemphigus Vulgaris
Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus. Pemphigus was derived from the Greek word ''pemphix'', meaning blister. It is classified as a type II hypersensitivity reaction in which antibodies are formed against desmosomes, components of the skin that function to keep certain layers of skin bound to each other. As desmosomes are attacked, the layers of skin separate and the clinical picture resembles a blister. These blisters are due to acantholysis, or breaking apart of intercellular connections through an autoantibody-mediated response. Over time the condition inevitably progresses without treatment: lesions increase in size and distribution throughout the body, behaving physiologically like a severe burn. Before the advent of modern treatments, mortality for the disease was close to 90%. Today, the mortality rate with treatment is between 5-15% due to the introduction of corticosteroids as primary treatment. Nevertheless, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pemphigus Vegetans Of Hallopeau
Pemphigus vegetans is a localized form of pemphigus vulgaris. in which there is a localized vegetating papillomatous response. The eroded areas do not heal like usual but form papillomatous growth and vegetation. Accounts for 1-2% of pemphigus cases and is a relatively benign variant of pemphigus vulgaris. Two forms are recognized: * ''Pemphigus vegetans of Neumann'' is a localized disease of pemphigus vulgaris slightly more extensive than pemphigus vegetans of Hallopeau. This type is more common and characterized by early lesions similar to Pemphigus Vulgaris with large bullae and erosive areas. Healing is through formation of granulation tissue. It is named for the Austrian Dermatologist, Isidor Neumann. * ''Pemphigus vegetans of Hallopeau'' is a disease of localized pemphigus vulgaris. It is named for François Henri Hallopeau. This type is less aggressive and has pustules not bullae. These pustules heal by verrucous hyperkeratotic vegetations. See also * List of cutan ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isidor Neumann
Isidor Neumann, Edler von Heilwart (2 March 1832, Mißlitz, Moravia – 31 August 1906) was an Austrian dermatologist. He was a student at the so-called Vienna School of Dermatology under Ferdinand Ritter von Hebra (1816–1880), earning his doctorate in 1858. In 1863 he received his habilitation, and in 1873 became an associate professor. In 1881 he was appointed professor of dermatology and successor to Carl Ludwig Sigmund (1810–1883) as director of the clinic for syphilis. In an 1886 publication of ''Vierteljahrsschrift für Dermatologie und Syphilis'', he described a type of pemphigus vulgaris, which later became known as Pemphigus vegetans of Neumann. He was also the first to publish a detailed study (''Über die senilen Veränderungen der Haut des Menschen'') of prematurely aged skin caused by over-exposure to weather conditions. However it wasn't until several years later that Paul Gerson Unna (1850-1929) gave it a name, calling it ''seemannshaut'' or "sailors' skin". ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
François Henri Hallopeau
__NOTOC__ François Henri Hallopeau (17 January 1842, Paris – 20 March 1919, Paris) was a French dermatologist. He studied medicine under Alfred Vulpian and Sigismond Jaccoud. He co-founded and was secretary general of the ''Société Française de dermatologie et de syphiligraphie''. He became a member of the ''Académie de Médecine'' in 1893. He coined the medical term ''trichotillomania'' in 1889. He also coined the word ''antibiotique'' in 1871 to describe a substance opposed to the development of life. Selman Waksman was later credited with coining the word ''antibiotic'' to describe such compounds that were derived from other living organisms, such as penicillin. Terms * Recessive dystrophic epidermolysis bullosa (also known as Hallopeau-Siemens syndrome) * Pemphigus vegetans of Hallopeau Papers * * * * * * See also *Timeline of tuberous sclerosis The history of tuberous sclerosis (TSC) research spans less than 200 years. TSC is a rare, multi-system genetic disea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Cutaneous Conditions
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against the external environment. The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin.Burns, Tony; ''et al''. (2006) ''Rook's Textbook of Dermatology CD-ROM''. Wiley-Blackwell. . Within the latter type, the hairs occur in structures called pilosebaceous units, each with hair follicle, sebaceous gland, and associated arrector pili muscle. In the embryo, the epidermis, hair, and glands form from the ectoderm, which is chemically influenced by the underlying mesoderm th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pemphigus
Pemphigus ( or ) is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. The name is derived from the Greek root ''pemphix'', meaning "pustule". In pemphigus, autoantibodies form against desmoglein, which forms the "glue" that attaches adjacent epidermal cells via attachment points called desmosomes. When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes detached, a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases, these blisters can cover a large area of the skin. Originally, the cause of this disease was unknown, and "pemphigus" was used to refer to any blistering disease of the skin and mucosa. In 1964, researchers found that the blood of patients with pemphigus contained antibodies to the layers of skin that separate to form the blisters. In 1971, an article investigating the autoimmune nature of this disease was published ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Conditions Caused By Problems With Junctional Proteins
Mutations of proteins that hold the cells of the skin together can cause disease. Autoantibodies against proteins that hold the cells of the skin together can also cause disease. See also * List of keratins expressed in the human integumentary system * List of target antigens in pemphigus * List of immunofluorescence findings for autoimmune bullous conditions * List of cutaneous conditions * List of genes mutated in cutaneous conditions * List of histologic stains that aid in diagnosis of cutaneous conditions * Keratoderma Keratoderma is a hornlike skin condition. Classification The keratodermas are classified into the following subgroups:Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. . Congenital * Simple ker ... References * * {{DEFAULTSORT:Cutaneous conditions caused by problems with junctional proteins Junctional proteins Dermatology-related lists ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
