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Pamela Bjorkman
Pamela Jane Bjorkman NAS, AAAS (also spelled Pamela J. Björkman; born 1956, Portland, Oregon) is an American biochemist and molecular biologist. She is the David Baltimore Professor of Biology and Biological Engineering at the California Institute of Technology (Caltech). Her research centers on the study of the three-dimensional structures of proteins related to Class I MHC, or Major Histocompatibility Complex, proteins of the immune system, and proteins involved in the immune responses to viruses. Bjorkman's goal is to improve current therapeutic applications. Bjorkman is most well known as a pioneer in the field of structural biology. Early life and education Bjorkman was born in 1956 and grew up in Parkrose, a neighborhood in Portland, Oregon. She became interested in science in high school and attended Willamette University for one year before transferring to the University of Oregon, where she earned a Bachelor of Arts degree in Chemistry. As an undergraduate student, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Portland, Oregon
Portland (, ) is a port city in the Pacific Northwest and the largest city in the U.S. state of Oregon. Situated at the confluence of the Willamette and Columbia rivers, Portland is the county seat of Multnomah County, the most populous county in Oregon. Portland had a population of 652,503, making it the 26th-most populated city in the United States, the sixth-most populous on the West Coast, and the second-most populous in the Pacific Northwest, after Seattle. Approximately 2.5 million people live in the Portland metropolitan statistical area (MSA), making it the 25th most populous in the United States. About half of Oregon's population resides within the Portland metropolitan area. Named after Portland, Maine, the Oregon settlement began to be populated in the 1840s, near the end of the Oregon Trail. Its water access provided convenient transportation of goods, and the timber industry was a major force in the city's early economy. At the turn of the 20th century, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parkrose, Portland, Oregon
Parkrose is a neighborhood in the Northeast section of Portland, Oregon, and is considered part of East Portland. It is bordered by Sumner to the west, the Columbia River to the north, Argay to the east, and Parkrose Heights and the city of Maywood Park to the south. Sandy Boulevard crosses the neighborhood, with a primarily industrial area prevailing to the north and primarily residential area to the south. There is a Parkrose/Sumner Transit Center, which is served by the Red Line of TriMet's MAX Light Rail. A bridge at the transit center spans Interstate 205. C-Tran serves the transit center and travels into Washington. There is also a Parkrose School District. History The Parkrose plat was filed October 5, 1911. A branch post office of Portland was established there in 1921. Parkrose was a small farming and residential suburb of Portland until the 1920s. The ''Oregon Journal'' noted on May 23, 1925, "Parkrose is a primary commuting center... It is one of the most progre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatitis C Virus
The hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family ''Flaviviridae''. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer ( hepatocellular carcinoma, abbreviated HCC) and lymphomas in humans. Taxonomy The hepatitis C virus belongs to the genus ''Hepacivirus'', a member of the family ''Flaviviridae''. Before 2011, it was considered to be the only member of this genus. However a member of this genus has been discovered in dogs: canine hepacivirus. There is also at least one virus in this genus that infects horses. Several additional viruses in the genus have been described in bats and rodents. Structure The hepatitis C virus particle consists of a lipid membrane envelope that is 55 to 65 nm in diameter. Two viral envelope glycoproteins, E1 and E2, are embedded in the lipid envelope. They take part in viral attachment and entry into the cell. Within the envel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Influenza
Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin from one to four days after exposure to the virus (typically two days) and last for about 2–8 days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia, which can be caused by the virus or by a subsequent bacterial infection. Other complications of infection include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease. There are four types of influenza virus, termed influenza viruses A, B, C, and D. Aquatic birds are the primary source of Influenza A virus (IAV), which is also widespread in various mammals, including humans and pigs. Influenza B virus (IBV) and Influenza C virus (ICV) pri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subtypes Of HIV
The subtypes of HIV include two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa, while HIV-2 viruses are related to viruses found in the sooty mangabey, a vulnerable West African primate. HIV-1 viruses can be further divided into groups M, N, O and P. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Group M can be further subdivided into subtypes based on genetic sequence data. Some of the subtypes are known to be more virulent or are resistant to different medications. Likewise, HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses, although HIV-2 is also known to cause AIDS. One of the obstacles to treatment of the human immunodeficiency virus (HIV) is its high genetic variability. Major types HIV-1 HIV-1 is the most common and pathogenic strain of the virus. Over 2 million such infections occur annually. Scientists ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
T-cell Receptor
The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively low affinity and is degenerate: that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR. The TCR is composed of two different protein chains (that is, it is a heterodimer). In humans, in 95% of T cells the TCR consists of an alpha (α) chain and a beta (β) chain (encoded by '' TRA'' and ''TRB'', respectively), whereas in 5% of T cells the TCR consists of gamma and delta (γ/δ) chains (encoded by '' TRG'' and '' TRD'', respectively). This ratio changes during ontogeny and in diseased states (such as leukemia). It also differs between species. Orthologues of the 4 loci have been mapped in various species. Each locus can produce a vari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mark M
Mark may refer to: Currency * Bosnia and Herzegovina convertible mark, the currency of Bosnia and Herzegovina * East German mark, the currency of the German Democratic Republic * Estonian mark, the currency of Estonia between 1918 and 1927 * Finnish markka ( sv, finsk mark, links=no), the currency of Finland from 1860 until 28 February 2002 * Mark (currency), a currency or unit of account in many nations * Polish mark ( pl, marka polska, links=no), the currency of the Kingdom of Poland and of the Republic of Poland between 1917 and 1924 German * Deutsche Mark, the official currency of West Germany from 1948 until 1990 and later the unified Germany from 1990 until 2002 * German gold mark, the currency used in the German Empire from 1873 to 1914 * German Papiermark, the German currency from 4 August 1914 * German rentenmark, a currency issued on 15 November 1923 to stop the hyperinflation of 1922 and 1923 in Weimar Germany * Lodz Ghetto mark, a special currency for Lodz Ghetto. * R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is considered among the most prestigious universities in the world. Stanford was founded in 1885 by Leland and Jane Stanford in memory of their only child, Leland Stanford Jr., who had died of typhoid fever at age 15 the previous year. Leland Stanford was a U.S. senator and former governor of California who made his fortune as a railroad tycoon. The school admitted its first students on October 1, 1891, as a coeducational and non-denominational institution. Stanford University struggled financially after the death of Leland Stanford in 1893 and again after much of the campus was damaged by the 1906 San Francisco earthquake. Following World War II, provost of Stanford Frederick Terman inspired and supported faculty and graduates' entrepreneu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antigen
In immunology, an antigen (Ag) is a molecule or molecular structure or any foreign particulate matter or a pollen grain that can bind to a specific antibody or T-cell receptor. The presence of antigens in the body may trigger an immune response. The term ''antigen'' originally referred to a substance that is an antibody generator. Antigens can be proteins, peptides (amino acid chains), polysaccharides (chains of monosaccharides/simple sugars), lipids, or nucleic acids. Antigens are recognized by antigen receptors, including antibodies and T-cell receptors. Diverse antigen receptors are made by cells of the immune system so that each cell has a specificity for a single antigen. Upon exposure to an antigen, only the lymphocytes that recognize that antigen are activated and expanded, a process known as clonal selection. In most cases, an antibody can only react to and bind one specific antigen; in some instances, however, antibodies may cross-react and bind more than one antigen. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HLA-A*02
HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. Before this revision, HLA-A*02 was also referred to as HLA-A2, HLA-A02, and HLA-A*2. HLA-A*02 is one particular class I major histocompatibility complex (MHC) allele group at the HLA-A locus. The A*02 allele group can code for many proteins; as of December 2013 there are 456 different HLA-A*02 proteins. Serotyping can identify as far as HLA-A*02, which is typically enough to prevent transplant rejection (the original motivation for HLA identification). Genes can further be separated by genetic sequencing and analysis. HLAs can be identified with as many as nine numbers and a letter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X-ray Crystallography
X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angles and intensities of these diffracted beams, a crystallographer can produce a three-dimensional picture of the density of electrons within the crystal. From this electron density, the mean positions of the atoms in the crystal can be determined, as well as their chemical bonds, their crystallographic disorder, and various other information. Since many materials can form crystals—such as salts, metals, minerals, semiconductors, as well as various inorganic, organic, and biological molecules—X-ray crystallography has been fundamental in the development of many scientific fields. In its first decades of use, this method determined the size of atoms, the lengths and types of chemical bonds, and the atomic-scale differences among various mat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Don Craig Wiley
Don, don or DON and variants may refer to: Places *County Donegal, Ireland, Chapman code DON *Don (river), a river in European Russia *Don River (other), several other rivers with the name *Don, Benin, a town in Benin *Don, Dang, a village and hill station in Dang district, Gujarat, India *Don, Nord, a ''commune'' of the Nord ''département'' in northern France *Don, Tasmania, a small village on the Don River, located just outside Devonport, Tasmania *Don, Trentino, a commune in Trentino, Italy *Don, West Virginia, a community in the United States *Don Republic, a temporary state in 1918–1920 *Don Jail, a jail in Toronto, Canada People Role or title *Don (honorific), a Spanish, Portuguese, and Italian title, given as a mark of respect *Don, a crime boss, especially in the Mafia , ''Don Konisshi'' (コニッシー) *Don, a resident assistant at universities in Canada and the U.S. *University don, in British and Irish universities, especially at Oxford, Cambridge, St And ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
