Pamela Bjorkman
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Pamela Bjorkman
Pamela Jane Bjorkman NAS, AAAS (also spelled Pamela J. Björkman; born 1956, Portland, Oregon) is an American biochemist and molecular biologist. She is the David Baltimore Professor of Biology and Biological Engineering at the California Institute of Technology (Caltech). Her research centers on the study of the three-dimensional structures of proteins related to Class I MHC, or Major Histocompatibility Complex, proteins of the immune system, and proteins involved in the immune responses to viruses. Bjorkman's goal is to improve current therapeutic applications. Bjorkman is most well known as a pioneer in the field of structural biology. Early life and education Bjorkman was born in 1956 and grew up in Parkrose, a neighborhood in Portland, Oregon. She became interested in science in high school and attended Willamette University for one year before transferring to the University of Oregon, where she earned a Bachelor of Arts degree in Chemistry. As an undergraduate student, ...
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Portland, Oregon
Portland (, ) is a port city in the Pacific Northwest and the largest city in the U.S. state of Oregon. Situated at the confluence of the Willamette and Columbia rivers, Portland is the county seat of Multnomah County, the most populous county in Oregon. Portland had a population of 652,503, making it the 26th-most populated city in the United States, the sixth-most populous on the West Coast, and the second-most populous in the Pacific Northwest, after Seattle. Approximately 2.5 million people live in the Portland metropolitan statistical area (MSA), making it the 25th most populous in the United States. About half of Oregon's population resides within the Portland metropolitan area. Named after Portland, Maine, the Oregon settlement began to be populated in the 1840s, near the end of the Oregon Trail. Its water access provided convenient transportation of goods, and the timber industry was a major force in the city's early economy. At the turn of the 20th century, the ...
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Parkrose, Portland, Oregon
Parkrose is a neighborhood in the Northeast section of Portland, Oregon, and is considered part of East Portland. It is bordered by Sumner to the west, the Columbia River to the north, Argay to the east, and Parkrose Heights and the city of Maywood Park to the south. Sandy Boulevard crosses the neighborhood, with a primarily industrial area prevailing to the north and primarily residential area to the south. There is a Parkrose/Sumner Transit Center, which is served by the Red Line of TriMet's MAX Light Rail. A bridge at the transit center spans Interstate 205. C-Tran serves the transit center and travels into Washington. There is also a Parkrose School District. History The Parkrose plat was filed October 5, 1911. A branch post office of Portland was established there in 1921. Parkrose was a small farming and residential suburb of Portland until the 1920s. The ''Oregon Journal'' noted on May 23, 1925, "Parkrose is a primary commuting center... It is one of the most progre ...
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Hepatitis C Virus
The hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family ''Flaviviridae''. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer ( hepatocellular carcinoma, abbreviated HCC) and lymphomas in humans. Taxonomy The hepatitis C virus belongs to the genus ''Hepacivirus'', a member of the family ''Flaviviridae''. Before 2011, it was considered to be the only member of this genus. However a member of this genus has been discovered in dogs: canine hepacivirus. There is also at least one virus in this genus that infects horses. Several additional viruses in the genus have been described in bats and rodents. Structure The hepatitis C virus particle consists of a lipid membrane envelope that is 55 to 65 nm in diameter. Two viral envelope glycoproteins, E1 and E2, are embedded in the lipid envelope. They take part in viral attachment and entry into the cell. Within the envel ...
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Influenza
Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin from one to four days after exposure to the virus (typically two days) and last for about 2–8 days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia, which can be caused by the virus or by a subsequent bacterial infection. Other complications of infection include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease. There are four types of influenza virus, termed influenza viruses A, B, C, and D. Aquatic birds are the primary source of Influenza A virus (IAV), which is also widespread in various mammals, including humans and pigs. Influenza B virus (IBV) and Influenza C virus (ICV) pri ...
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Subtypes Of HIV
The subtypes of HIV include two major types, HIV type 1 (HIV-1) and HIV type 2 (HIV-2). HIV-1 is related to viruses found in chimpanzees and gorillas living in western Africa, while HIV-2 viruses are related to viruses found in the sooty mangabey, a vulnerable West African primate. HIV-1 viruses can be further divided into groups M, N, O and P. The HIV-1 group M viruses predominate and are responsible for the AIDS pandemic. Group M can be further subdivided into subtypes based on genetic sequence data. Some of the subtypes are known to be more virulent or are resistant to different medications. Likewise, HIV-2 viruses are thought to be less virulent and transmissible than HIV-1 M group viruses, although HIV-2 is also known to cause AIDS. One of the obstacles to treatment of the human immunodeficiency virus (HIV) is its high genetic variability. Major types HIV-1 HIV-1 is the most common and pathogenic strain of the virus. Over 2 million such infections occur annually. Scientists ...
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