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PAQR9
Membrane progesterone receptor epsilon (mPRɛ), or progestin and adipoQ receptor 9 (PAQR9), is a protein that in humans is encoded by the ''PAQR9'' gene. See also * Membrane progesterone receptor * Progestin and adipoQ receptor The progestin and adipoQ receptor (PAQR) family is a group of receptors related to but distinct from the G protein-coupled receptor family, which have the similar seven transmembrane structure, but the N-terminal is located on the inner side of ... References Further reading * 7TM receptors {{gene-3-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Membrane Progesterone Receptor
Membrane progesterone receptors (mPRs) are a group of cell surface receptors and membrane steroid receptors belonging to the progestin and adipoQ receptor (PAQR) family which bind the endogenous progestogen and neurosteroid progesterone, as well as the neurosteroid allopregnanolone. Unlike the progesterone receptor (PR), a nuclear receptor which mediates its effects via genomic mechanisms, mPRs are cell surface receptors which rapidly alter cell signaling via modulation of intracellular signaling cascades. The mPRs mediate important physiological functions in male and female reproductive tracts, liver, neuroendocrine tissues, and the immune system as well as in breast and ovarian cancer. The mPRs appear to be involved in the neuroprotective and antigonadotropic effects of progesterone and allopregnanolone. The progesterone active metabolites 5α-dihydroprogesterone, also a progestogen, and allopregnanolone, which are positive allosteric modulators of the GABAA receptor, have been ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progestin And AdipoQ Receptor
The progestin and adipoQ receptor (PAQR) family is a group of receptors related to but distinct from the G protein-coupled receptor family, which have the similar seven transmembrane structure, but the N-terminal is located on the inner side of the cell. It includes at least 11 receptors (PAQR1–PAQR11), including the adiponectin (adipoQ) receptors (AdipoRs), the membrane progesterone receptors (mPRs), and others. In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoRs identification data, as accused by an anonymous person/group called Ordinary_researchers.University of Tokyo to investigate data manipulation charges agains ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
