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P7C3
P7C3 (pool 7, compound 3) is a drug related to latrepirdine (dimebon) which has neuroprotective and neurogenesis, proneurogenic effects and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders. The pharmacology, pharmacological effects of P7C3 ''in vitro'' resemble those of endogenous neurotrophin, proneurogenic peptides such as fibroblast growth factor 1 (FGF-1), and the proneurogenic activity of P7C3 was around thirty times that of latrepirdine when they were compared in mice. P7C3 was chosen for further animal studies on the basis of favorable pharmacokinetic factors, such as its high oral administration, oral bioavailability and long duration of action, but several other related compounds showed similar activity such as the more potent fluorinated analogue P7C3A20 which is up to ten times stronger again, and the methoxy analogue P7C3-OMe, for which it was determined that the (''R'') enantiomer is the active form. The mech ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
P7C3 Derivatives
P7C3 (pool 7, compound 3) is a drug related to latrepirdine (dimebon) which has neuroprotective and neurogenesis, proneurogenic effects and may be potentially useful for the treatment of Alzheimer's disease and similar neurodegenerative disorders. The pharmacology, pharmacological effects of P7C3 ''in vitro'' resemble those of endogenous neurotrophin, proneurogenic peptides such as fibroblast growth factor 1 (FGF-1), and the proneurogenic activity of P7C3 was around thirty times that of latrepirdine when they were compared in mice. P7C3 was chosen for further animal studies on the basis of favorable pharmacokinetic factors, such as its high oral administration, oral bioavailability and long duration of action, but several other related compounds showed similar activity such as the more potent fluorinated analogue P7C3A20 which is up to ten times stronger again, and the methoxy analogue P7C3-OMe, for which it was determined that the (''R'') enantiomer is the active form. The mech ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |