Purified Protein Derivative
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Purified Protein Derivative
Tuberculin, also known as purified protein derivative, is a combination of proteins that are used in the diagnosis of tuberculosis. This use is referred to as the tuberculin skin test and is recommended only for those at high risk. Reliable administration of the skin test requires large amounts of training, supervision, and practice. Injection is done into the skin. After 48 to 72 hours, if there is more than a five to ten millimeter area of swelling, the test is considered positive. Common side effects include redness, itchiness, and pain at the site of injection. Allergic reactions may occasionally occur. The test may be falsely positive in those who have been previously vaccinated with BCG or have been infected by other types of mycobacteria. The test may be falsely negative within ten weeks of infection, in those less than six months old, and in those who have been infected for many years. Use is safe in pregnancy. Tuberculin was discovered in 1890 by Robert Koch. Koch, b ...
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Intradermal
Intradermal injection, often abbreviated ID, is a shallow or superficial injection of a substance into the dermis, which is located between the epidermis and the hypodermis. For certain substances, administration via an ID route can result in a faster systemic uptake compared with subcutaneous injections, leading to a stronger immune response to vaccinations, immunology and novel cancer treatments, and faster drug uptake. Additionally, since administration is closer to the surface of the skin, the body's reaction to substances is more easily visible. However, due to complexity of the procedure compared to subcutaneous injection and intramuscular injection, administration via ID is relatively rare, and is only used for tuberculosis and allergy tests, Monkeypox vaccination, and certain therapies. Injection sites Common injection sites include the inner surface of the forearm and the upper back, under the shoulder blade. Equipment Equipment include syringes calibrated in tenths an ...
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Clemens Von Pirquet
Clemens Peter Freiherr von Pirquet (12 May 187428 February 1929) was an Austrian scientist and pediatrician best known for his contributions to the fields of bacteriology and immunology. Career Born in Vienna, he studied theology at the University of Innsbruck and philosophy at the University of Leuven before he enrolled at the University of Graz where he became a doctor of medicine in 1900. He started practicing at the Children's Clinic in Vienna. In 1906 he noticed that patients who had previously received injections of horse serum or smallpox vaccine had quicker, more severe reactions to a second injection. He coined the word allergy (from the Greek ''allos'' meaning "other" and ''ergon'' meaning "work") to describe this hypersensitivity reaction. Soon after, the observation with smallpox led Pirquet to realize that tuberculin, which Robert Koch isolated from the bacteria that cause tuberculosis in 1890, might lead to a similar type of reaction. Charles Mantoux expanded up ...
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Diphtheria
Diphtheria is an infection caused by the bacterium '' Corynebacterium diphtheriae''. Most infections are asymptomatic or have a mild clinical course, but in some outbreaks more than 10% of those diagnosed with the disease may die. Signs and symptoms may vary from mild to severe and usually start two to five days after exposure. Symptoms often come on fairly gradually, beginning with a sore throat and fever. In severe cases, a grey or white patch develops in the throat. This can block the airway and create a barking cough as in croup. The neck may swell in part due to enlarged lymph nodes. A form of diphtheria which involves the skin, eyes or genitals also exists. Complications may include myocarditis, inflammation of nerves, kidney problems, and bleeding problems due to low levels of platelets. Myocarditis may result in an abnormal heart rate and inflammation of the nerves may result in paralysis. Diphtheria is usually spread between people by direct contact or through th ...
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Emil Von Behring
Emil von Behring (; Emil Adolf von Behring), born Emil Adolf Behring (15 March 1854 – 31 March 1917), was a German physiologist who received the 1901 Nobel Prize in Physiology or Medicine, the first one awarded in that field, for his discovery of a diphtheria antitoxin. He was widely known as a "saviour of children," as diphtheria used to be a major cause of child death. His work with the disease, as well as tetanus, has come to bring him most of his fame and acknowledgment. He was honored with Prussian nobility in 1901, henceforth being known by the surname "von Behring." Biography Behring was born in Hansdorf, Kreis Rosenberg, Province of Prussia (now Ławice, Iława County, Poland). His father was a schoolmaster; the family had 13 children. Between 1874 and 1878, he studied medicine at the Kaiser-Wilhelm-Akademie in Berlin, an academy for military doctors, since his family could not afford the university. As a military doctor, he studied the action of iodoform. Due to his w ...
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Rudolf Virchow
Rudolf Ludwig Carl Virchow (; or ; 13 October 18215 September 1902) was a German physician, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician. He is known as "the father of modern pathology" and as the founder of social medicine, and to his colleagues, the "Pope of medicine". Virchow studied medicine at the Friedrich Wilhelm University under Johannes Peter Müller. While working at the Charité hospital, his investigation of the 1847–1848 typhus epidemic in Upper Silesia laid the foundation for public health in Germany, and paved his political and social careers. From it, he coined a well known aphorism: "Medicine is a social science, and politics is nothing else but medicine on a large scale". His participation in the Revolution of 1848 led to his expulsion from Charité the next year. He then published a newspaper ''Die Medizinische Reform'' (''The Medical Reform''). He took the first Chair of Pathological Anatomy at the University of Wü ...
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German Gold Mark
The German mark (german: Goldmark ; sign: ℳ) was the currency of the German Empire, which spanned from 1871 to 1918. The mark was paired with the minor unit of the pfennig (₰); 100 pfennigs were equivalent to 1 mark. The mark was on the gold standard from 1871–1914, but like most nations during World War I, the German Empire removed the gold backing in August 1914, and gold and silver coins ceased to circulate. After the fall of the Empire due to the November Revolution of 1918, the mark was succeeded by the Weimar Republic's mark, derisively referred to as the Papiermark ("Paper mark") due to hyperinflation in the Weimar Republic from 1918–1923. History The introduction of the German mark in 1873 was the culmination of decades-long efforts to unify the various currencies used by the German Confederation.pp 205-218 https://books.google.com/books?id=GrJCAAAAIAAJ&pg=PA205#v=onepage&q&f=false The Zollverein unified in 1838 the Prussian and South German currenc ...
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Greifswald
Greifswald (), officially the University and Hanseatic City of Greifswald (german: Universitäts- und Hansestadt Greifswald, Low German: ''Griepswoold'') is the fourth-largest city in the German state of Mecklenburg-Western Pomerania after Rostock, Schwerin and Neubrandenburg. In 2021 it surpassed Stralsund for the first time, and became the largest city in the Pomeranian part of the state. It sits on the River Ryck, at its mouth into the Danish Wiek (''Dänische Wiek''), a sub-bay of the Bay of Greifswald (''Greifswalder Bodden''), which is itself a sub-bay of the Bay of Pomerania (''Pommersche Bucht'') of the Baltic Sea. It is the seat of the district of Western Pomerania-Greifswald, and is located roughly in the middle between the two largest Pomeranian islands of Rugia (''Rügen'') and Usedom. The closest larger cities are Stralsund, Rostock, Szczecin and Schwerin. It lies west of the River Zarow, the historical cultural and linguistic boundary between West (west of the r ...
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Alfred Grotjahn
Alfred Grotjahn (25 November 1869 – 4 September 1931) was a German German(s) may refer to: * Germany (of or related to) **Germania (historical use) * Germans, citizens of Germany, people of German ancestry, or native speakers of the German language ** For citizens of Germany, see also German nationality law **Ge ... physician, :de:Sozialhygiene, social hygienist, Eugenics, eugenicist, journalist-author and, for three years between 1921 and 1924, a :de: Liste der Reichstagsabgeordneten der Weimarer Republik (1. Wahlperiode), Member of the Reichstag (Weimar Republic), Reichstag (national parliament) in the recently launched Weimar Republic, German republic. He became celebrated as a pioneer, and among admirers an inventor, of the discipline of :de:Sozialhygiene , "social hygiene" which, in Germany, was not merely an ephemeral euphemism for the sociological study of sexually transmitted diseases, but embraced a series of topics along the interface between sociology and medicine. W ...
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Social Hygiene Movement
The social hygiene movement was an attempt by Progressive era reformers to control venereal disease, regulate prostitution and vice, and disseminate sexual education through the use of scientific research methods and modern media techniques. Social hygiene as a profession grew alongside social work and other public health movements of the era. Social hygienists emphasized sexual continence and strict self-discipline as a solution to societal ills, tracing prostitution, drug use and illegitimacy to rapid urbanization. The movement remained alive throughout much of the 20th century and found its way into American schools, where it was transmitted in the form of classroom films about menstruation, sexually transmitted disease, drug abuse and acceptable sexual behavior in addition to an array of pamphlets, posters, textbooks and films. History The social hygiene movement of the late 19th and early 20th centuries was an attempt by Progressive-era reformers to control venereal disease, ...
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Order Of The Red Eagle
The Order of the Red Eagle (german: Roter Adlerorden) was an order of chivalry of the Kingdom of Prussia. It was awarded to both military personnel and civilians, to recognize valor in combat, excellence in military leadership, long and faithful service to the kingdom, or other achievements. As with most German (and most other European) orders, the Order of the Red Eagle could only be awarded to commissioned officers or civilians of approximately equivalent status. However, there was a medal of the order, which could be awarded to non-commissioned officers and enlisted men, lower ranking civil servants and other civilians. History The predecessor to the Order of the Red Eagle was founded on 17 November 1705, by the Margrave Georg Wilhelm of Brandenburg-Bayreuth as the '' Ordre de la Sincerité''. This soon fell into disuse but was revived in 1712 in Brandenburg-Bayreuth and again in 1734 in Brandenburg-Ansbach, where it first received the name of "Order of the Brandenburg Red Eagle ...
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Phenazone
Phenazone (INN and BAN; also known as phenazon, antipyrine (USAN), or analgesine) is an analgesic (pain reducing), antipyretic (fever reducing) and anti-inflammatory drug. While it predates the term, it is often classified as a nonsteroidal anti-inflammatory drug (NSAID). Phenazone was one of the earliest synthetic medications — when it was patented in 1883, the only synthetic medical chemicals on the market were chloral hydrate, a sedative (as well as at least one derivative of that chemical), trimethylamine, and iodol (tetraiodopyrrol), an early antiseptic. One of the earliest widely used analgesics and antipyretics, phenazone was gradually replaced in common use by other medications including phenacetin (itself later withdrawn because of safety concerns), aspirin, paracetamol and modern NSAIDs such as ibuprofen. However, it is still available in several countries either as an over-the-counter or prescribed drug. History Ludwig Knorr was the first to synthesize phenazone, t ...
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International Medical Congress
The International Medical Congress (french: Congrès International de Médecine) was a series of international scientific conferences on medicine that took place, periodically, from 1867 until 1913. The idea of such a congress came in 1865, during the third annual Medical Congress of France; Professor Henri Giutrac proposed holding an international medical conference in 1867, taking advantage of the fact that physicians and surgeons from all over the world would surely be in Paris to attend that year's International Exhibition. The first congress was a great success; it enjoyed the patronage of the French Government, having been officially attended by Victor Duruy, Minister of Public Instruction, and had several honorary members selected from foreign diplomatic bodies and learned societies. Congresses Proposed Congress The 18th Congress was due to be held in Munich in 1917, as unanimously agreed by the permanent commission of the International Congress at the 17th Congre ...
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