Pseuderanthemum Carruthersii
''Pseuderanthemum carruthersii'', the Carruthers' falseface, is a species of plant in the family Acanthaceae. It is native from the Solomon Islands to Vanuatu. Chemical analysis The Carruthers' falseface is highly used in researches for extracting many chemical compounds. The following chemicals can be found in the plant. Lignans * Eudesmin * Magnolin * Syringaresinol * Episyringaresinol * 1-hydroxysyringaresinol * Pseuderesinol * Pseuderanoside Triterpenes * Squalene * Oleanolic acid * Lupeol * Betulin * Betulinic acid Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase. I ... * Pseuderanic acid References carruthersii {{Acanthaceae-stub ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Plant
Plants are predominantly photosynthetic eukaryotes of the kingdom Plantae. Historically, the plant kingdom encompassed all living things that were not animals, and included algae and fungi; however, all current definitions of Plantae exclude the fungi and some algae, as well as the prokaryotes (the archaea and bacteria). By one definition, plants form the clade Viridiplantae (Latin name for "green plants") which is sister of the Glaucophyta, and consists of the green algae and Embryophyta (land plants). The latter includes the flowering plants, conifers and other gymnosperms, ferns and their allies, hornworts, liverworts, and mosses. Most plants are multicellular organisms. Green plants obtain most of their energy from sunlight via photosynthesis by primary chloroplasts that are derived from endosymbiosis with cyanobacteria. Their chloroplasts contain chlorophylls a and b, which gives them their green color. Some plants are parasitic or mycotrophic and have lost the ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Betulinic Acid
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase. It is found in the bark of several species of plants, principally the white birch (''Betula pubescens'') from which it gets its name, but also the ber tree (''Ziziphus mauritiana''), selfheal (''Prunella vulgaris''), the tropical carnivorous plants '' Triphyophyllum peltatum'' and ''Ancistrocladus heyneanus'', '' Diospyros leucomelas'', a member of the persimmon family, '' Tetracera boiviniana'', the jambul (''Syzygium formosanum''), flowering quince (''Pseudocydonia sinensis'', former ''Chaenomeles sinensis KOEHNE''), (''Chaenomeles sinensis KOEHNE'' is now named ''Pseudocydonia sinensis'') rosemary, and ''Pulsatilla chinensis''. Antitumor activity In 1995, betulinic acid was reported as a selective inhibitor of human melanoma. Then i ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Betulin
Betulin is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees. It forms up to 30% of the dry weight of silver birch bark. It is also found in birch sap. '' Inonotus obliquus'' and red alder also contain betulin. The compound in the bark gives the tree its white color which appears to protect the tree from mid-winter overheating by the sun. As a result, birches are some of the northernmost occurring deciduous trees. It can be converted to betulinic acid (the alcohol group replaced by a carboxylic acid group), which is biologically more active than betulin itself. History Betulin was discovered in 1788 by German-Russian chemist Johann Tobias Lowitz. Chemistry Chemically, betulin is a triterpenoid of lupane structure. It has a pentacyclic ring structure, and hydroxyl groups in positions C3 and C28. Biological activities Preliminary ''in vitro'' studies have shown that betulin demonstrates anti-cancer properties against a variety ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Lupeol
Lupeol is a pharmacologically active pentacyclic triterpenoid. It has several potential medicinal properties, like anticancer and anti-inflammatory activity. Natural occurrences Lupeol is found in a variety of plants, including mango, '' Acacia visco'' and '' Abronia villosa''. It is also found in dandelion coffee. Lupeol is present as a major component in ''Camellia japonica'' leaf. Total synthesis The first total synthesis of lupeol was reported by Gilbert Stork ''et al''. In 2009, Surendra and Corey reported a more efficient and enantioselective total synthesis of lupeol, starting from (''1E,5E'')-8- ''2S'')-3,3-dimethyloxiran-2-yl2,6-dimethylocta-1,5-dienyl acetate by use of a polycyclization. Biosynthesis Lupeol is produced by several organisms from squalene epoxide. Dammarane and baccharane skeletons are formed as intermediates. The reactions are catalyzed by the enzyme lupeol synthase. A recent study on the metabolomics of ''Camellia japonica'' leaf revealed t ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Oleanolic Acid
Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins. Natural occurrence Oleanolic acid can be found in olive oil, ''Phytolacca americana'' (American pokeweed), and ''Syzygium'' spp, garlic, etc. It was first studied and isolated from several plants, including ''Olea europaea'' (leaves, fruit), ''Rosa woodsii'' (leaves), ''Prosopis glandulosa'' (leaves and twigs), '' Phoradendron juniperinum'' (whole plant), '' Syzygium claviflorum'' (leaves), '' Hyptis capitata'' (whole plant), ''Mirabilis jalapa'') and ''Ternstroemia gymnanthera'' (aerial part). Other ''Syzygium'' species including java apple (''Syzygium samarangense'') and rose apples contain it, as does ''Ocimum tenuiflorum'' (holy basil). Biosynthesis of oleanolic acids Oleanolic acid biosynthesis starts with mevalonate to create squalene. Squalen ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Squalene
Squalene is an organic compound. It is a triterpenoid with the formula C30H50. It is a colourless oil, although impure samples appear yellow. It was originally obtained from shark liver oil (hence its name, as ''Squalus'' is a genus of sharks). All plants and animals produce squalene as a biochemical intermediate to sterol biosynthesis. An estimated 12% of bodily squalene in humans is found in Sebaceous gland, sebum. Squalene has a role in topical skin lubrication and protection. Squalene is a precursor (chemistry), precursor for synthesis of all plant and animal sterols, including cholesterol and steroid hormones in the human body. Squalene is an important ingredient in some vaccine adjuvants: The Novartis and GlaxoSmithKline adjuvants are called MF59 and AS03, respectively. Role in steroid synthesis Squalene is the biochemical precursor to steroids. The squalene conversion begins with oxidation (via squalene monooxygenase) of one of its terminal double bonds, resulting in 2,3- ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Triterpene
Triterpenes are a class of chemical compounds composed of three terpene units with the molecular formula C30H48; they may also be thought of as consisting of six isoprene units. Animals, plants and fungi all produce triterpenes, including squalene, the precursor to all steroids. Structures Triterpenes exist in a great variety of structures. Nearly 200 different skeletons have been identified. These skeletons may be broadly divided according to the number of rings present. In general pentacyclic structures (5 rings) tend to dominate. Squalene is biosynthesized through the head-to-head condensation of two farnesyl pyrophosphate units. This coupling converts a pair of C15 components into a C30 product. Squalene serves as precursor for the formation of many triterpenoids, including bacterial hopanoids and eukaryotic sterols. Triterpenoids By definition triterpenoids are triterpenes that possess heteroatoms, usually oxygen. The terms ''triterpene'' and ''triterpenoid'' oft ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |
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Acanthaceae
Acanthaceae is a family (the acanthus family) of dicotyledonous flowering plants containing almost 250 genera and about 2500 species. Most are tropical herbs, shrubs, or twining vines; some are epiphytes. Only a few species are distributed in temperate regions. The four main centres of distribution are Indonesia and Malaysia, Africa, Brazil, and Central America. Representatives of the family can be found in nearly every habitat, including dense or open forests, scrublands, wet fields and valleys, sea coast and marine areas, swamps, and mangrove forests. Description Plants in this family have simple, opposite, decussated leaves with entire (or sometimes toothed, lobed, or spiny) margins, and without stipules. The leaves may contain cystoliths, calcium carbonate concretions, seen as streaks on the surface. The flowers are perfect, zygomorphic to nearly actinomorphic, and arranged in an inflorescence that is either a spike, raceme, or cyme. Typically, a colorful bract subtends ea ... [...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]   |