Positron Emission Mammography
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Positron Emission Mammography
Positron emission mammography (PEM) is a nuclear medicine imaging modality used to detect or characterise breast cancer. Mammography typically refers to x-ray imaging of the breast, while PEM uses an injected positron emitting isotope and a dedicated scanner to locate breast tumors. Scintimammography is another nuclear medicine breast imaging technique, however it is performed using a gamma camera. Breasts can be imaged on standard whole-body PET scanners, however dedicated PEM scanners offer advantages including improved Image resolution, resolution. PEM is not recommended for routine use or for breast cancer screening, in part due to higher radiation dose compared to other modalities. Compared to breast MRI, PEM offers higher Sensitivity and specificity, specificity. Specific indications can include "high-risk patients with masses > 2 cm or aggressive malignancy and serum tumor marker elevation". Fludeoxyglucose (18F), 18F-FDG is the most common radiopharmaceutical used for PEM. ...
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Positron Emission Mammography
Positron emission mammography (PEM) is a nuclear medicine imaging modality used to detect or characterise breast cancer. Mammography typically refers to x-ray imaging of the breast, while PEM uses an injected positron emitting isotope and a dedicated scanner to locate breast tumors. Scintimammography is another nuclear medicine breast imaging technique, however it is performed using a gamma camera. Breasts can be imaged on standard whole-body PET scanners, however dedicated PEM scanners offer advantages including improved Image resolution, resolution. PEM is not recommended for routine use or for breast cancer screening, in part due to higher radiation dose compared to other modalities. Compared to breast MRI, PEM offers higher Sensitivity and specificity, specificity. Specific indications can include "high-risk patients with masses > 2 cm or aggressive malignancy and serum tumor marker elevation". Fludeoxyglucose (18F), 18F-FDG is the most common radiopharmaceutical used for PEM. ...
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Fludeoxyglucose (18F)
[18F]Fluorodeoxyglucose (International Nonproprietary Name, INN), or fluorodeoxyglucose F 18 (United States Adopted Name, USAN and United States Pharmacopeia, USP), also commonly called fluorodeoxyglucose and abbreviated [18F]FDG, 2-[18F]FDG or FDG, is a radiopharmaceutical, specifically a radiotracer, used in the medical imaging modality positron emission tomography (PET). Chemically, it is 2-deoxy-2-[18F]fluoro-D-glucose, a glucose analog (chemistry), analog, with the positron-emitting radionuclide fluorine-18 substituted for the normal hydroxyl group at the C-2 position in the glucose molecule. The uptake of [18F]FDG by tissues is a marker for the tissue Glucose uptake, uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. After [18F]FDG is injected into a patient, a PET scanner can form two-dimensional or three-dimensional images of the distribution of [18F]FDG within the body. Since its development in 1976, [18F]FDG had a profound in ...
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2d Nuclear Medical Imaging
D, or d, is the fourth letter in the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''dee'' (pronounced ), plural ''dees''. History The Semitic letter Dāleth may have developed from the logogram for a fish or a door. There are many different Egyptian hieroglyphs that might have inspired this. In Semitic, Ancient Greek and Latin, the letter represented ; in the Etruscan alphabet the letter was archaic, but still retained (see letter B). The equivalent Greek letter is Delta, Δ. Architecture The minuscule (lower-case) form of 'd' consists of a lower-story left bowl and a stem ascender. It most likely developed by gradual variations on the majuscule (capital) form 'D', and today now composed as a stem with a full lobe to the right. In handwriting, it was common to start the arc to the left of the vertical stroke, resulting in a serif at the top of the arc. This serif w ...
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Breast Ultrasound
Breast ultrasound is the use of medical ultrasonography to perform imaging of the breast. It can be considered either a diagnostic or a screening procedure. It may be used either with or without a mammogram. It may be useful in younger women, where the denser fibrous tissue of the breast may make mammograms more difficult to interpret. Automated whole-breast ultrasound (AWBU) is an ultrasound investigation of the breast that is largely independent of the operator skill and that allows the reconstruction of volumetric images of the breast. Using high-frequency ultrasound, a diagnostic evaluation of the lactiferous ducts by means of ultrasound (duct sonography) can be performed. In this manner, dilated ducts and intraductal masses can be made visible. Another technique for visualizing the system of lactiferous ducts is galactography, which allows a wider area of the lactiferous duct system to be visualized. A type of ultrasound examination to measure tissue stiffness, which is u ...
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United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ...
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Tomographic Reconstruction
Tomographic reconstruction is a type of multidimensional inverse problem where the challenge is to yield an estimate of a specific system from a finite number of projections. The mathematical basis for tomographic imaging was laid down by Johann Radon. A notable example of applications is the reconstruction of computed tomography (CT) where cross-sectional images of patients are obtained in non-invasive manner. Recent developments have seen the Radon transform and its inverse used for tasks related to realistic object insertion required for testing and evaluating computed tomography use in airport security. This article applies in general to reconstruction methods for all kinds of tomography, but some of the terms and physical descriptions refer directly to the reconstruction of X-ray computed tomography. Introducing formula The projection of an object, resulting from the tomographic measurement process at a given angle \theta, is made up of a set of line integrals (see F ...
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Electron–positron Annihilation
Electron–positron annihilation occurs when an electron () and a positron (, the electron's antiparticle) collide. At low energies, the result of the collision is the annihilation of the electron and positron, and the creation of energetic photons: : +  →  +  At high energies, other particles, such as B mesons or the W and Z bosons, can be created. All processes must satisfy a number of conservation laws, including: * Conservation of electric charge. The net charge before and after is zero. *Conservation of linear momentum and total energy. This forbids the creation of a single photon. However, in quantum field theory this process is allowed; see examples of annihilation. *Conservation of angular momentum. *Conservation of total (i.e. net) lepton number, which is the number of leptons (such as the electron) minus the number of antileptons (such as the positron); this can be described as a conservation of (net) matter law. As with any two charged ...
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Photon
A photon () is an elementary particle that is a quantum of the electromagnetic field, including electromagnetic radiation such as light and radio waves, and the force carrier for the electromagnetic force. Photons are massless, so they always move at the speed of light in vacuum, (or about ). The photon belongs to the class of bosons. As with other elementary particles, photons are best explained by quantum mechanics and exhibit wave–particle duality, their behavior featuring properties of both waves and particles. The modern photon concept originated during the first two decades of the 20th century with the work of Albert Einstein, who built upon the research of Max Planck. While trying to explain how matter and electromagnetic radiation could be in thermal equilibrium with one another, Planck proposed that the energy stored within a material object should be regarded as composed of an integer number of discrete, equal-sized parts. To explain the photoelectric effect, Eins ...
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Electron
The electron ( or ) is a subatomic particle with a negative one elementary electric charge. Electrons belong to the first generation of the lepton particle family, and are generally thought to be elementary particles because they have no known components or substructure. The electron's mass is approximately 1/1836 that of the proton. Quantum mechanical properties of the electron include an intrinsic angular momentum ( spin) of a half-integer value, expressed in units of the reduced Planck constant, . Being fermions, no two electrons can occupy the same quantum state, in accordance with the Pauli exclusion principle. Like all elementary particles, electrons exhibit properties of both particles and waves: They can collide with other particles and can be diffracted like light. The wave properties of electrons are easier to observe with experiments than those of other particles like neutrons and protons because electrons have a lower mass and hence a longer de Broglie wavele ...
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Annihilation
In particle physics, annihilation is the process that occurs when a subatomic particle collides with its respective antiparticle to produce other particles, such as an electron colliding with a positron to produce two photons. The total energy and momentum of the initial pair are conserved in the process and distributed among a set of other particles in the final state. Antiparticles have exactly opposite additive quantum numbers from particles, so the sums of all quantum numbers of such an original pair are zero. Hence, any set of particles may be produced whose total quantum numbers are also zero as long as conservation of energy and conservation of momentum are obeyed. During a low-energy annihilation, photon production is favored, since these particles have no mass. High-energy particle colliders produce annihilations where a wide variety of exotic heavy particles are created. The word "annihilation" takes use informally for the interaction of two particles that are not mu ...
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PEM System (in Use)
PEM or Pem may refer to: People * Pem Sluijter (1939–2007), Dutch poet Science * Photoelastic modulator * Polyelectrolyte multilayer * Positron emission mammography * Proton exchange membrane, semipermeable Engineering *Plastic encapsulated microcircuits, a method for packaging microcircuits *Power entry module * PEM nut or self-clinching nut Computing * PCI Express Mini, a computer bus standard * Privacy-Enhanced Mail, whose file format is also often used for X.509 certificates Medicine * Polioencephalomalacia * Protein-energy malnutrition * Pediatric emergency medicine * Post-exertional malaise Other * Parallel Economic Model, a theoretical dual economy model * Peabody Essex Museum, an art and historical museum located in Salem, Massachusetts, US * Padre Aldamiz International Airport, Madre de Dios, Peru, IATA code * Pemberton railway station, England; National Rail station code * Pembrokeshire, county in Wales, Chapman code * Private electronic market A private electr ...
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Radiopharmaceutical
Radiopharmaceuticals, or medicinal radiocompounds, are a group of pharmaceutical drugs containing radioactive isotopes. Radiopharmaceuticals can be used as diagnostic and therapeutic agents. Radiopharmaceuticals emit radiation themselves, which is different from contrast media which absorb or alter external electromagnetism or ultrasound. Radiopharmacology is the branch of pharmacology that specializes in these agents. The main group of these compounds are the radiotracers used to diagnose dysfunction in body tissues. While not all medical isotopes are radioactive, radiopharmaceuticals are the oldest and still most common such drugs. Drug nomenclature As with other pharmaceutical drugs, there is standardization of the drug nomenclature for radiopharmaceuticals, although various standards coexist. The International Nonproprietary Names (INNs), United States Pharmacopeia (USP) names, and IUPAC names for these agents are usually similar other than trivial style differences. The d ...
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