Pomeranz–Fritsch Reaction
The Pomeranz–Fritsch reaction, also named Pomeranz–Fritsch cyclization, is a named reaction in organic chemistry. It is named after Paul Fritsch (chemist), Paul Fritsch (1859–1913) and Cäsar Pomeranz (1860–1926). In general it is a synthesis of isoquinoline. General reaction scheme The reaction below shows the acid-promoted synthesis of isoquinoline from benzaldehyde and a 2,2-dialkoxyethylamine. Various alkyl, alkyl groups, e.g. methyl and ethyl group, ethyl groups, can be used as substituent R. In the archetypical reaction sulfuric acid was used as proton donor, but Lewis acids such as trifluoroacetic anhydride and lanthanide triflates have been used occasionally. Later, a wide range of diverse isoquinolines were successfully prepared. Reaction mechanism A possible mechanism is depicted below: First the benzalaminoacetal 1 is built by the condensation reaction, condensation of benzaldehyde and a 2,2-dialkoxyethylamine. After the condensation a hydrogen-atom i ...
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Paul Fritsch (chemist)
Paul Fritsch (25 February 1901 – 22 September 1970) was a French featherweight professional boxing, boxer who competed in the early 1920s. In 1920 he became the first French boxer to win an Olympic title, defeating teammate Jean Gachet in the final, despite losing to Gachet at the national championships before the Olympics. After more than 300 amateur bouts, Fritsch turned professional in 1921. He fought approximately 100 more bouts, but never won a major title. He retired from boxing in 1929 due to a retinal d