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Peroxiredoxin Classification Index
PeroxiRedoxin classification indEX (PREX ) is a database of peroxiredoxins (Prxs) classified into one of six distinct subfamilies. Classification relies on the Deacon Active Site Profiling (DASP) approach that utilizes a position specific scoring matrix (PSSM) created from aligned signatures (built from sequence fragments surrounding active sites of structurally-characterized Prx group members) to search sequence databases. Searches of PREX for Prxs of interest can be conducted using protein annotation, accession number, PDB ID, organism name, or protein sequence (using BLAST) for Prx proteins extracted from January 2008, November 2010, or October 2011 versions of GenBank (over 8000 validated Prx sequences represented). Output includes the subfamily to which each classified Prx belongs, accession and GI numbers, genus and species, and the active site signature used for classification. The query sequence is also presented aligned with a select group of Prxs for manual evaluation an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases spans formal techniques and practical considerations, including data modeling, efficient data representation and storage, query languages, security and privacy of sensitive data, and distributed computing issues, including supporting concurrent access and fault tolerance. A database management system (DBMS) is the software that interacts with end users, applications, and the database itself to capture and analyze the data. The DBMS software additionally encompasses the core facilities provided to administer the database. The sum total of the database, the DBMS and the associated applications can be referred to as a database system. Often the term "database" is also used loosely to refer to any of the DBMS, the database system or an appli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peroxiredoxin
Peroxiredoxins (Prxs, ; HGNC root symbol ''PRDX'') are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells. The family members in humans are PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6. The physiological importance of peroxiredoxins is indicated by their relative abundance (one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin 2). Their function is the reduction of peroxides, specifically hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite. Classification Prxs were historically divided into three (mechanistic) classes: *Typical 2-Cys Prxs *Atypical 2-Cys Prxs and *1-Cys Prxs. The designation of "1-Cys" and "2-Cys" Prxs was introduced in 1994 as it was noticed that, among the 22 Prx sequences known at the time, only one Cys residue was absolutely conserved; this is the residue now recognized as the (required) peroxidatic cysteine, CP. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wake Forest University
Wake Forest University is a private research university in Winston-Salem, North Carolina. Founded in 1834, the university received its name from its original location in Wake Forest, north of Raleigh, North Carolina. The Reynolda Campus, the university's main campus, has been located north of downtown Winston-Salem since the university moved there in 1956. The Atrium Health Wake Forest Baptist medical campus has two locations, the older one located near the Ardmore neighborhood in central Winston-Salem, and the newer campus at Wake Forest Innovation Quarter downtown. The university also occupies lab space at Biotech Plaza at Innovation Quarter, and at the Center for Nanotechnology and Molecular Materials. The university's Graduate School of Management maintains a presence on the main campus in Winston-Salem and in Charlotte, North Carolina. WFU's undergraduate and graduate colleges and schools include Wake Forest University School of Law, Wake Forest University School of Divi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jacquelyn S
Jacqueline is a female given name. Origins Jacqueline comes from French, as the feminine form of Jacques (English James). Jacques originated from 'Jacob', which is derived from the Hebrew meaning 'may God protect' or 'supplanter'. ''Supplanter'' refers to a person who replaces someone or a thing of lesser value, and this Hebrew meaning refers to Jacob's supplanting Esau as recorded in the Hebrew Bible. 'May God protect' has a more positive connotation and is, therefore, the preferred meaning for the name. Jacqueline was first used in 17th century England. Variant and diminutive forms It has spelling variations and many variants in both spelling and pronunciation have come into use, such as Jacquelyn, Jacquelin, Jackeline, Jackielyn, Jacklyn, and Jaclyn. The diminutive for Jacqueline is Jacquie, Jackie, Jacque or Jacqui, which also has many variants. Popularity Jacqueline is a very popular female first name,1990 U.S. Census used in the United States, Canada, England, Fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peroxiredoxin
Peroxiredoxins (Prxs, ; HGNC root symbol ''PRDX'') are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels and thereby mediate signal transduction in mammalian cells. The family members in humans are PRDX1, PRDX2, PRDX3, PRDX4, PRDX5, and PRDX6. The physiological importance of peroxiredoxins is indicated by their relative abundance (one of the most abundant proteins in erythrocytes after hemoglobin is peroxiredoxin 2). Their function is the reduction of peroxides, specifically hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite. Classification Prxs were historically divided into three (mechanistic) classes: *Typical 2-Cys Prxs *Atypical 2-Cys Prxs and *1-Cys Prxs. The designation of "1-Cys" and "2-Cys" Prxs was introduced in 1994 as it was noticed that, among the 22 Prx sequences known at the time, only one Cys residue was absolutely conserved; this is the residue now recognized as the (required) peroxidatic cysteine, CP. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Databases
Biological databases are libraries of biological sciences, collected from scientific experiments, published literature, high-throughput experiment technology, and computational analysis. They contain information from research areas including genomics, proteomics, metabolomics, microarray gene expression, and phylogenetics. Information contained in biological databases includes gene function, structure, localization (both cellular and chromosomal), clinical effects of mutations as well as similarities of biological sequences and structures. Biological databases can be classified by the kind of data they collect (see below). Broadly, there are molecular databases (for sequences, molecules, etc.), functional databases (for physiology, enzyme activities, phenotypes, ecology etc), taxonomic databases (for species and other taxonomic ranks), images and other media, or specimens (for museum collections etc.) Databases are important tools in assisting scientists to analyze and explain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
