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Pacific Symposium On Biocomputing
The Pacific Symposium on Biocomputing (PSB) is an annual multidisciplinary scientific meeting co-founded in 1996 by Dr. Teri Klein, Dr. Lawrence Hunter and Sharon Surles. The conference is to presentation and discuss research in the theory and application of computational methods for biology. Papers and presentations are peer reviewed and published. PSB brings together researchers from the US and the Asian Pacific nations, to exchange research results and address open issues in all aspects of computational biology. PSB is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology. The PSB aims for "critical mass" in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by ...
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Hawaii
Hawaii ( ; haw, Hawaii or ) is a state in the Western United States, located in the Pacific Ocean about from the U.S. mainland. It is the only U.S. state outside North America, the only state that is an archipelago, and the only state geographically located within the tropics. Hawaii comprises nearly the entire Hawaiian archipelago, 137 volcanic islands spanning that are physiographically and ethnologically part of the Polynesian subregion of Oceania. The state's ocean coastline is consequently the fourth-longest in the U.S., at about . The eight main islands, from northwest to southeast, are Niihau, Kauai, Oahu, Molokai, Lānai, Kahoolawe, Maui, and Hawaii—the last of these, after which the state is named, is often called the "Big Island" or "Hawaii Island" to avoid confusion with the state or archipelago. The uninhabited Northwestern Hawaiian Islands make up most of the Papahānaumokuākea Marine National Monument, the United States' largest protected ...
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Scientific Meeting
An academic conference or scientific conference (also congress, symposium, workshop, or meeting) is an event for researchers (not necessarily academics) to present and discuss their scholarly work. Together with academic or scientific journals and Preprint archives such as arXiv, conferences provide an important channel for exchange of information between researchers. Further benefits of participating in academic conferences include learning effects in terms of presentation skills and “academic habitus”, receiving feedback from peers for one’s own research, the possibility to engage in informal communication with peers about work opportunities and collaborations, and getting an overview of current research in one or more disciplines. Overview Conferences usually encompass various presentations. They tend to be short and concise, with a time span of about 10 to 30 minutes; presentations are usually followed by a . The work may be bundled in written form as academic pape ...
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Teri Klein
Teri E. Klein is an American professor of Biomedical Data Science and Medicine (and of Genetics, by courtesy) at Stanford University. She is known for her work on pharmacogenomics and computational biology. Education Klein has a B.A. from the University of California, Santa Cruz (1980) and a Ph.D. from the University of California, San Francisco (1987). In 2000 she started a position at Stanford University where, as of 2022 she holds the position of professor (research). She is a co-founder of the Pacific Symposium on Biocomputing and is a Principal Investigator for PharmGKB, Clinical Pharmacogenomics Implementation Consortium (CPIC), The Pharmacogenomic Clinical Annotation Tool (PharmCAT), and Clinical Genome Resource (ClinGen). Selected publications * * * * Awards and honors Klein was named a fellow of the American College of Medical Informatics in 2001. In 2021, she was named a fellow of the American Association for the Advancement of Science The American Association ...
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Peer Review
Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work (peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review methods are used to maintain quality standards, improve performance, and provide credibility. In academia, scholarly peer review is often used to determine an academic paper's suitability for publication. Peer review can be categorized by the type of activity and by the field or profession in which the activity occurs, e.g., medical peer review. It can also be used as a teaching tool to help students improve writing assignments. Henry Oldenburg (1619–1677) was a German-born British philosopher who is seen as the 'father' of modern scientific peer review. Professional Professional peer review focuses on the performance of professionals, with a view to improving quality, upholding standards, or providing certification. In academia, peer ...
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United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ...
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Asia-Pacific
Asia-Pacific (APAC) is the part of the world near the western Pacific Ocean. The Asia-Pacific region varies in area depending on context, but it generally includes East Asia, Russian Far East, South Asia, Southeast Asia, Australia and Pacific Islands. Definition The term may include countries in North America and South America that are on the coast of the Eastern Pacific Ocean; the Asia-Pacific Economic Cooperation, for example, includes Canada, Chile, Mexico, Peru, and the United States. Alternatively, the term sometimes comprises all of Asia and Australasia as well as Pacific island nations (Asia-Pacific and Australian continent)—for example, when dividing the world into large regions for commercial purposes (e.g., into APAC, EMEA, LATAM, and NA). Central Asia and Western Asia are almost never included.
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Computational Biology
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. It differs from biological computing, a subfield of computer engineering which uses bioengineering to build computers. History Bioinformatics, the analysis of informatics processes in biological systems, began in the early 1970s. At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms. This use of biological data pushed biological researchers to use computers to evaluate and compare large data sets in their own field. By 1982, researchers shared information via punch cards. The amount of data grew exponentially by the end of the 1980s, requiring new computational methods for quickly interpreting ...
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Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ...
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Critical Mass (sociodynamics)
In social dynamics, critical mass is a sufficient number of adopters of a new idea, technology or innovation in a social system so that the rate of adoption becomes self-sustaining and creates further growth. The point at which critical mass is achieved is sometimes referred to as a threshold within the threshold model of statistical modeling. The term critical mass is borrowed from nuclear physics and in that field, it refers to the amount of a substance needed to sustain a chain reaction. Within social sciences, critical mass has its roots in sociology and is often used to explain the conditions under which reciprocal behavior is started within collective groups, and how it becomes self-sustaining. Recent technology research in platform ecosystems shows that apart from the quantitative notion of a “sufficient number” critical mass is also influenced by qualitative properties such as reputation, interests, commitments, capabilities, goals, consensuses, and decisions, all of w ...
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Bioinformatics
Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combines biology, chemistry, physics, computer science, information engineering, mathematics and statistics to analyze and interpret the biological data. Bioinformatics has been used for '' in silico'' analyses of biological queries using computational and statistical techniques. Bioinformatics includes biological studies that use computer programming as part of their methodology, as well as specific analysis "pipelines" that are repeatedly used, particularly in the field of genomics. Common uses of bioinformatics include the identification of candidates genes and single nucleotide polymorphisms (SNPs). Often, such identification is made with the aim to better understand the genetic basis of disease, unique adaptations, desirable properties (e ...
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Research
Research is "creativity, creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, characterized by a particular attentiveness to controlling sources of bias and error. These activities are characterized by accounting and controlling for biases. A research project may be an expansion on past work in the field. To test the validity of instruments, procedures, or experiments, research may replicate elements of prior projects or the project as a whole. The primary purposes of basic research (as opposed to applied research) are documentation, Discovery (observation), discovery, interpretation (philosophy), interpretation, and the research and development (R&D) of methods and systems for the advancement of human knowledge. Approaches to research depend on epistemology, epistemologies, which vary considerably both within and between humanities and sciences. ...
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Research Parasite Award
The Research Parasite Award is an honor given annually at the Pacific Symposium on Biocomputing to recognize scientists who study previously-published data in ways not anticipated by the researchers who first generated it. The tongue-in-cheek name of the award refers to a ''New England Journal of Medicine'' editorial that coined the term "research parasite" to disparage such work. The idea was first suggested on Twitter by Iowa State University researcher Iddo Friedberg shortly after the editorial was published, and was then brought to life by Casey Greene, a pharmacologist at the University of Pennsylvania. Two Research Parasite Awards are given to recognize scientists who have made outstanding and rigorous contributions to analysis of secondary data in biology. Recipients must reuse data generated by someone else to extend, replicate, or disprove a research study in a reproducible manner. The junior parasite award recognizes an outstanding contribution from an early career scient ...
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