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Owen Sansom
Owen Sansom, FRSE., FMedSci is the Director of the Cancer Research UK Beatson Institute (formerly known as the Beatson Institute for Cancer Research). He is known for his work determining the molecular hallmarks of colorectal cancer (CRC), including demonstrating the roles of the tumour suppressor protein APC and the WNT signalling pathway, as well as the involvement of intestinal stem cells in tumourigenesis Education After obtaining a BSc in genetics from the University of Nottingham and an MRes in Biology from the University of Manchester, Owen went on to obtain a PhD from the University of Edinburgh. Career Owen was a postdoctoral fellow at Cardiff University investigating the role of the ''APC'' gene in Wnt signalling and cancer. In 2005, he became a Junior Group Leader at the Cancer Research UK Beatson Institute, and in 2011 he was appointed the Institute's Deputy Director. In 2016, the Institute's Director, Professor Karen Vousden moved to the Francis Crick Institute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Beatson Institute For Cancer Research
The Beatson Institute for Cancer Research (also known as the Cancer Research UK Beatson Institute) is a biological research facility that conducts research into the basic biology of cancer. It is based in Glasgow, Scotland. The Institute is named in recognition of Sir George Beatson, a surgeon, who in 1912 established a research department in the cancer hospital in Glasgow. This department became independent from the hospital in 1967 when the Institute was founded by the then Director, Dr John Paul. Dr Paul raised sufficient funds to move the Beatson in 1976 to its present location on the Garscube Estate, where it has since interacted closely with researchers at the University of Glasgow. The Institute moved in 2008 to a new research building built by Reiach and Hall Architects. Professor John Wyke became Director in 1987, Professor Karen Vousden in 2002 and Professor Owen Sansom in 2017. Research groups at the Beatson Institute study cancer initiation, metabolism and metasta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francis Crick Institute
The Francis Crick Institute (formerly the UK Centre for Medical Research and Innovation) is a biomedical research centre in London, which was established in 2010 and opened in 2016. The institute is a partnership between Cancer Research UK, Imperial College London, King's College London (KCL), the Medical Research Council, University College London (UCL) and the Wellcome Trust. The institute has 1,500 staff, including 1,250 scientists, and an annual budget of over £100 million, making it the biggest single biomedical laboratory in Europe. The institute is named after the molecular biologist, biophysicist, and neuroscientist Francis Crick, co-discoverer of the structure of DNA, who shared the 1962 Nobel Prize for Physiology and Medicine with James Watson and Maurice Wilkins. Unofficially, the Crick has been called ''Sir Paul's Cathedral'', a reference to Sir Paul Nurse and St Paul's Cathedral in London. History Background In 2003, the Medical Research Council decided that its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Molecular Biologists
British may refer to: Peoples, culture, and language * British people, nationals or natives of the United Kingdom, British Overseas Territories, and Crown Dependencies. ** Britishness, the British identity and common culture * British English, the English language as spoken and written in the United Kingdom or, more broadly, throughout the British Isles * Celtic Britons, an ancient ethno-linguistic group * Brittonic languages, a branch of the Insular Celtic language family (formerly called British) ** Common Brittonic, an ancient language Other uses *''Brit(ish)'', a 2018 memoir by Afua Hirsch *People or things associated with: ** Great Britain, an island ** United Kingdom, a sovereign state ** Kingdom of Great Britain (1707–1800) ** United Kingdom of Great Britain and Ireland (1801–1922) See also * Terminology of the British Isles * Alternative names for the British * English (other) * Britannic (other) * British Isles * Brit (other) * Briton (d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alumni Of The University Of Edinburgh
This is a list of notable graduates as well as non-graduate former students, academic staff, and university officials of the University of Edinburgh in Scotland. It also includes those who may be considered alumni by extension, having studied at institutions that later merged with the University of Edinburgh. The university is associated with 19 Nobel Prize laureates, three Turing Award winners, an Abel Prize laureate and Fields Medallist, four Pulitzer Prize winners, three Prime Ministers of the United Kingdom, and several Olympic gold medallists. Government and politics Heads of state and government United Kingdom Cabinet and Party Leaders Scottish Cabinet and Party Leaders Current Members of the House of Commons * Wendy Chamberlain, MP for North East Fife * Joanna Cherry, MP for Edinburgh South West * Colin Clark, MP for Gordon * Anneliese Dodds, MP for Oxford East * Kate Green, MP for Stretford and Urmston * John Howell, MP for Henley * Neil Hudson, M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alumni Of The University Of Manchester
Alumni (singular: alumnus (masculine) or alumna (feminine)) are former students of a school, college, or university who have either attended or graduated in some fashion from the institution. The feminine plural alumnae is sometimes used for groups of women. The word is Latin and means "one who is being (or has been) nourished". The term is not synonymous with "graduate"; one can be an alumnus without graduating ( Burt Reynolds, alumnus but not graduate of Florida State, is an example). The term is sometimes used to refer to a former employee or member of an organization, contributor, or inmate. Etymology The Latin noun ''alumnus'' means "foster son" or "pupil". It is derived from PIE ''*h₂el-'' (grow, nourish), and it is a variant of the Latin verb ''alere'' "to nourish".Merriam-Webster: alumnus .. Separate, but from the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alumni Of The University Of Nottingham
A list of people related to the University of Nottingham or to its predecessor, University College, Nottingham. Office holders Chancellors * John Boot, 2nd Baron Trent (1949 - 1954) * William Cavendish-Bentinck, 7th Duke of Portland (1954 - 1971) * Sir Francis Hill (1971 - 1978) * Sir Gordon Hobday (1978 - 1993) * Ronald Dearing, Baron Dearing (1993 - 2000) * Fujia Yang (2000 - 2012) * Sir Andrew Witty (2013–2017) * Baroness Young of Hornsey (2020–present) Vice-Chancellors * Bertrand Hallward (1948 - 1965) * Frederick Dainton, Baron Dainton (1965 - 1970) * John Butterfield, Baron Butterfield (1971 - 1975) * Basil Weedon (1976 - 1988) * Sir Colin Campbell (1988 - 2008) * Sir David Greenaway (2008 - September 2017) * Shearer West (October 2017 – present) Notable alumni Academia * Bob Boucher – Vice-Chancellor of the University of Sheffield * Arthur Carty – National Science Advisor to the Prime Minister of Canada * Sir Bernard Crossland – President of the Inst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1975 Births
It was also declared the ''International Women's Year'' by the United Nations and the European Architectural Heritage Year by the Council of Europe. Events January * January 1 - Watergate scandal (United States): John N. Mitchell, H. R. Haldeman and John Ehrlichman are found guilty of the Watergate cover-up. * January 2 ** The Federal Rules of Evidence are approved by the United States Congress. ** Bangladesh revolutionary leader Siraj Sikder is killed by police while in custody. ** A bomb blast at Samastipur, Bihar, India, fatally wounds Lalit Narayan Mishra, Minister of Railways. * January 5 – Tasman Bridge disaster: The Tasman Bridge in Hobart, Tasmania, Australia, is struck by the bulk ore carrier , killing 12 people. * January 7 – OPEC agrees to raise crude oil prices by 10%. * January 10–February 9 – The flight of '' Soyuz 17'' with the crew of Georgy Grechko and Aleksei Gubarev aboard the '' Salyut 4'' space station. * January 15 – Alvor Agreem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Edinburgh
The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established in 1783. , there are around 1,800 Fellows. The Society covers a broader selection of fields than the Royal Society of London, including literature and history. Fellowship includes people from a wide range of disciplines – science & technology, arts, humanities, medicine, social science, business, and public service. History At the start of the 18th century, Edinburgh's intellectual climate fostered many clubs and societies (see Scottish Enlightenment). Though there were several that treated the arts, sciences and medicine, the most prestigious was the Society for the Improvement of Medical Knowledge, commonly referred to as the Medical Society of Edinburgh, co-founded by the mathematician Colin Maclaurin in 1731. Maclaurin was unhappy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guanine Nucleotide Exchange Factor
Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase. Function Guanine nucleotide exchange factors (GEFs) are proteins or protein domains involved in the activation of small GTPases. Small GTPases act as molecular switches in intracellular signaling pathways and have many downstream targets. The most well-known GTPases comprise the Ras superfamily and are involved in essential cell processes such as cell differentiation and proliferation, cytoskeletal organization, vesicle trafficking, and nuclear transport. GTPases are active when bound to GTP and inactive when bound to GDP, allowing their activity to be regulated by GEFs and th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PTEN (gene)
Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the ''PTEN'' gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been identified in most mammals for which complete genome data are available. ''PTEN'' acts as a tumor suppressor gene through the action of its phosphatase protein product. This phosphatase is involved in the regulation of the cell cycle, preventing cells from growing and dividing too rapidly. It is a target of many anticancer drugs. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It nega ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
KRAS
''KRAS'' (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide ( proliferate) or to mature and take on specialized functions ( differentiate). It is called ''KRAS'' because it was first identified as a viral oncogene in the Kirsten RAt Sarcoma virus. The oncogene identified was derived from a cellular genome, so , when found in a cellular genome, is called a proto-oncogene. The K-Ras protein is a GTPase, a class of enzymes which convert the nucleotide guanosine triphosphate (GTP) into guanosine diphosphate (GDP). In this way the K-Ras protein acts like a switch that is turned on and off by the GTP and GDP molecules. To transmit signals, it must be turned on by attaching (binding) to a molecule of GTP. The K-Ras protein is turned off (inactivated) when it converts the GTP to GDP. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
