Oskar (gene)
''oskar'' is a gene required for the development of the ''Drosophila'' embryo. It defines the posterior pole during early embryogenesis. Its two isoforms, short and long, play different roles in Drosophila embryonic development. ''oskar'' was named after the main character from the Günter Grass novel The Tin Drum, who refuses to grow up. Evolutionary history ''oskar'' displays a unique evolutionary origin resulting from a Horizontal Domain Transfer from a probably bacterial endosymbiont onto an ancestral insect genome. The OSK domain is of bacterial origin and fused with the LOTUS domain through a linker domain. This event must have happened just prior to the divergence with the Crustacean, the insect's sister group, as ''oskar'' can be found as early as the Zygentoma but does not seem to exist in Crustacean. Translational-level regulation ''oskar'' is translationally repressed prior to reaching the posterior pole of the oocyte by Bruno, which binds to three bruno res ...
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