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Orsay Virus
Orsay virus is a positive-sense single-stranded RNA virus that infects ''Caenorhabditis elegans'' nematode. It resembles nodaviruses (family ''Nodaviridae''), but has yet to be formally classified. Orsay virus has a (+)ssRNA genome consisting of two segments, termed RNA1 and RNA2. The RNA1 segment encodes an RNA-dependent RNA polymerase (RdRP) of 982 amino acids.Guo, Y.R., et al., Crystal structure of a nematode-infecting virus. ''Proceedings of the National Academy of Sciences'', 2014. 111(35): p. 12781–12786. The RNA2 segment has two open reading frames (ORFs) that code for a capsid protein and a non-structural protein with unknown function. The virus is composed of two structural domains, a shell (S) and a protrusion (P) domain. Orsay virus was discovered in 2011 in ''Caenorhabditis elegans'' nematodes in rotting fruit in Orsay, France. Just before the time of the discovery, standardized methods were developed for the wild isolation of nematodes. Using these methods, ''Caen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Positive-sense Single-stranded RNA Virus
Positive-strand RNA viruses (+ssRNA viruses) are a group of related viruses that have positive-sense, single-stranded genomes made of ribonucleic acid. The positive-sense genome can act as messenger RNA (mRNA) and can be directly translated into viral proteins by the host cell's ribosomes. Positive-strand RNA viruses encode an RNA-dependent RNA polymerase (RdRp) which is used during replication of the genome to synthesize a negative-sense antigenome that is then used as a template to create a new positive-sense viral genome. Positive-strand RNA viruses are divided between the phyla ''Kitrinoviricota'', ''Lenarviricota'', and ''Pisuviricota'' (specifically classes ''Pisoniviricetes'' and '' Stelpavirictes'') all of which are in the kingdom '' Orthornavirae'' and realm '' Riboviria''. They are monophyletic and descended from a common RNA virus ancestor. In the Baltimore classification system, +ssRNA viruses belong to Group IV. Positive-sense RNA viruses include pathogens s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caenorhabditis Elegans
''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' (rod-like) and Latin ''elegans'' (elegant). In 1900, Maupas initially named it '' Rhabditides elegans.'' Osche placed it in the subgenus ''Caenorhabditis'' in 1952, and in 1955, Dougherty raised ''Caenorhabditis'' to the status of genus. ''C. elegans'' is an unsegmented pseudocoelomate and lacks respiratory or circulatory systems. Most of these nematodes are hermaphrodites and a few are males. Males have specialised tails for mating that include spicules. In 1963, Sydney Brenner proposed research into ''C. elegans,'' primarily in the area of neuronal development. In 1974, he began research into the molecular and developmental biology of ''C. elegans'', which has since been extensively used as a model organism. It was the first multicellu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nodaviridae
''Nodaviridae'' is a family of nonenveloped positive-strand RNA viruses. Vertebrates and invertebrates serve as natural hosts. Diseases associated with this family include: viral encephalopathy and retinopathy in fish. There are nine species in the family, assigned to two genera. History The name of the family is derived from the Japanese village of Nodamura, Iwate Prefecture where Nodamura virus was first isolated from ''Culex tritaeniorhynchus'' mosquitoes. Virology Structure The virus is not enveloped and has an icosahedral capsid (triangulation number = 3) ranging from 29 to 35 nm in diameter. The capsid is constructed of 32 capsomers. Genome The genome is linear, positive sense, bipartite (composed of two segments – RNA1 and RNA2) single stranded RNA consisting of 4500 nucleotides with a 5’ terminal methylated cap and a non-polyadenylated 3’ terminal. RNA1, which is ~3.1 kilobases in length, encodes a protein that has multiple functional domains: a mitoch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orsay
Orsay () is a Communes of France, commune in the Essonne Departments of France, department in Île-de-France in northern France. It is located in the southwestern suburbs of Paris, France, from the Kilometre Zero, centre of Paris. A fortified location of the Vallée de Chevreuse, Chevreuse valley since the 8th century and agricultural domain of wealthy and influential people, the development of Orsay is marked by the introduction of a Rail transport, railroad in the second half of the 18th century (today the RER B of which two stations are located in Orsay) and donations which allow the construction of a hospital still active to this day. Orsay is the main home to the Paris-Saclay University. The university significantly shapes Orsay's economy as it employs about 10,000 academic workers. The city's economy is also centered on high technology, with several companies drawn to the area by the Paris-Saclay's research and development infrastructure. Seat of the Orsay campus of Pa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caenorhabditis Briggsae
''Caenorhabditis briggsae'' is a small nematode, closely related to ''Caenorhabditis elegans''. The differences between the two species are subtle. The male tail in ''C. briggsae'' has a slightly different morphology from ''C. elegans''. Other differences include changes in vulval precursor competence and the placement of the excretory duct opening. ''C. briggsae'' is frequently used to study the differences between it and the more intimately understood ''C. elegans'', especially at the DNA and protein sequence level. Several mutant strains of ''C. briggsae'' have also been isolated that facilitate genetic analysis of this organism. ''C. briggsae'', like ''C. elegans'', is a hermaphrodite. The genome sequence for ''C. briggsae'' was determined in 2003. History ''C. briggsae'' was initially discovered by Margaret Briggs in 1944. The first individuals were isolated from a pile of leaves found on the Palo Alto campus of Stanford University. Briggs, who was studying for her MS, ide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Positive-sense Single-stranded RNA Viruses
In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. Depending on the context, sense may have slightly different meanings. For example, negative-sense strand of DNA is equivalent to the template strand, whereas the positive-sense strand is the non-template strand whose nucleotide sequence is equivalent to the sequence of the mRNA transcript. DNA sense Because of the complementary nature of base-pairing between nucleic acid polymers, a double-stranded DNA molecule will be composed of two strands with sequences that are reverse complements of each other. To help molecular biologists specifically identify each strand individually, the two strands are usually differentiated as the "sense" strand and the "antisense" strand. An individual strand of DNA is referred to as positive-sense (also positive (+) or simply sense ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Viral Diseases
Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia. With few exceptions, animals consume organic material, breathe oxygen, are able to move, can reproduce sexually, and go through an ontogenetic stage in which their body consists of a hollow sphere of cells, the blastula, during embryonic development. Over 1.5 million living animal species have been described—of which around 1 million are insects—but it has been estimated there are over 7 million animal species in total. Animals range in length from to . They have complex interactions with each other and their environments, forming intricate food webs. The scientific study of animals is known as zoology. Most living animal species are in Bilateria, a clade whose members have a bilaterally symmetric body plan. The Bilateria include the protostomes, containing animals such as nematodes, arthropods, flatworms, annelids and molluscs, and the deuterostomes, containing the echinoderms an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
