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Haplogroup C-M217
} Haplogroup C-M217, also known as C2 (and previously as C3), is a Y-chromosome DNA haplogroup. It is the most frequently occurring branch of the wider Haplogroup C (M130). It is found mostly in Central Asia, Eastern Siberia and significant frequencies in parts of East Asia and Southeast Asia including some populations in the Caucasus, Middle East, South Asia, East Europe. It is found in a much more widespread areas with a low frequency of less than 2%. The haplogroup C-M217 is now found at high frequencies among Central Asian peoples, indigenous Siberians, and some Native peoples of North America. In particular, males belonging to peoples such as the Buryats, Evens, Evenks, Itelmens, Kalmyks, Kazakhs, Koryaks, Mongolians, Negidals, Nivkhs, Udege, and Ulchi have high levels of M217. One particular haplotype within Haplogroup C2-M217 has received a great deal of attention, because of the possibility that it may represent direct patrilineal descent from Genghis Khan, thoug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
C2 Domain
A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. The typical version (PKC-C2) has a beta-sandwich composed of 8 beta sheet, β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face. Many other C2 domain families don't have calcium binding activity. Coupling with other domains C2 domains are frequently found coupled to enzyme, enzymatic domains; for example, the C2 domain in PTEN (gene), PTEN, brings the phosphatase domain into contact with the plasma membrane, where it can dephosphorylate its substrate, Phosphatidylinositol (3,4,5)-trisphosphate, phosphatidylinositol (3,4,5)-trisphosphate (PIP3), without removing it from the membrane - which would be energetically very costly. PTEN consists of two domains, a protein tyrosine phosphatase domain and a C2 domain. This domain pair constitutes a superdomain, a heritable unit that is found in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Common European Framework Of Reference For Languages
The Common European Framework of Reference for Languages: Learning, Teaching, Assessment, abbreviated in English as CEFR or CEF or CEFRL, is a guideline used to describe achievements of learners of foreign languages across Europe and, increasingly, in other countries. The CEFR is also intended to make it easier for educational institutions and employers to evaluate the language qualifications of candidates for education admission or employment. Its main aim is to provide a method of learning, teaching, and assessing that applies to all languages in Europe. It was put together by the Council of Europe as the main part of the project "Language Learning for European Citizenship" between 1989 and 1996. In November 2001, a European Union Council Resolution recommended using the CEFR to set up systems of validation of language ability. The six reference levels (A1, A2, B1, B2, C1, C2) are becoming widely accepted as the European standard for grading an individual's language profici ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complement Component 2
Complement C2 is a protein that in humans is encoded by the ''C2'' gene. The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases. Function In the classical and lectin pathways of complement activation, formation of the C3-convertase and C5-convertases requires binding of C2 to an activated surface-bound C4b in the presence of Mg2+; the resultant C4bC2 complex is cleaved by C1s Complement component 1s (, '' C1 esterase'', ''activated complement C1s'', ''complement C overbar 1r'', ''C1s'') is a protein involved in the complement system. C1s is part of the C1 complex. In humans, it is encoded by the ''C1S'' gene. C1s cle ... or MASP2 into C2a and C2b. It is thought that cleavage of C2 by C1s, while bound to C4b, results in a conformational rotation of C2b whereas the released C2a fragment may retain most of its original structur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nimrod NRA/C2
The Nimrod NRA/C2 was the only Group C racing car ever built by Nimrod Racing Automobiles in partnership with Aston Martin. It ran initially in 1982 in the World Endurance Championship before also joining the IMSA GT Championship. The final NRA/C2 would be retired in 1984 after the planned NRA/C3 replacement had been cancelled and the company went bankrupt. Development Beginning in 1981, Robin Hamilton hastily constructed a chassis for use as a test vehicle in preparation for competition in the 1982 season. This lone car, known as NRA/C1, was used to test design and mechanical features for the upcoming race car, the NRA/C2. For an engine, Aston Martin turned to their tuning arm Tickford for the development of a racing version of their production V8 engines seen in the V8 and V8 Vantage models. This engine, becoming known as "Development Prototype 1229" (DP1229), retained the same basic displacement of 5340 cc while being strengthened in order to handle the increased outp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Procyanidin C2
Procyanidin C2 is a B type proanthocyanidin trimer, a type of condensed tannin. Natural occurrences Procyanidin C2 is found in grape seeds (''Vitis vinifera'') and wine, in barley (''Hordeum vulgare''), malt and beer, in ''Betula spp.'', in ''Pinus radiata'', in '' Potentilla viscosa'', in ''Salix caprea'' or in ''Cryptomeria japonica''. The contents in barley grain of trimeric proanthocyanidins, including procyanidin C2, range from 53 to 151 μg catechin equivalents/g. Possible health uses Proanthocyanidin oligomers, extracted from grape seeds, have been used for the experimental treatment of androgenic alopecia. When applied topically, they promote hair growth ''in vitro'', and induce anagen ''in vivo''. Procyanidin C2 is the subtype of extract most effective. Experiments showed that both procyanidin C2 and Pycnogenol (French maritime pine bark extract) increase TNF-α secretion in a concentration- and time-dependent manner. These results demonstrate that procyanidins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BRDC C2 Championship
The BRDC C2 Championship (sometimes referred to as the British C2 Championship) was a short lived sports car racing series which ran from 1988 to 1990. The series was for Group C cars which fit into the smaller, less powerful, and cheaper C2 category. All races were run in the United Kingdom. The British Racing Drivers' Club ran the series during its lifetime. History Meant as a replacement for the dwindling Thundersports series, the C2 Championship would serve to bring international sports car racing seen in the World Sportscar Championship to Britain. By using the smaller C2 class only, the series was able to encourage more teams to enter not only due to the relatively low cost of the available cars, but also due to the lack of major automobile manufacturers to drive away competitors due to their dominance. This was also aided by the fact that there were already several British teams running C2 class cars on the international circuit. Although only seven cars would attend the op ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Group C2
Group C was a category of sports car racing introduced by the FIA in 1982 and continuing until 1993, with ''Group A'' for touring cars and ''Group B'' for GTs. It was designed to replace both Group 5 special production cars (closed top touring prototypes like Porsche 935) and Group 6 two-seat racing cars (open-top sportscar prototypes like Porsche 936). Group C was used in the FIA's World Endurance Championship (1982–1985), World Sports-Prototype Championship (1986–1990), World Sportscar Championship (1991–1992) and in the European Endurance Championship (1983 only). It was also used for other sports car racing series around the globe (All Japan Sports Prototype Championship, Supercup, Interserie). The final year for the class came in 1993. Broadly similar rules were used in the North American IMSA Grand Touring Prototype series ( GTP). History The roots of the Group C category lie in both FIA Group 6 and particularly in the GTP category introduced by the ACO at Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cervical Vertebra 2
In anatomy, the axis (from Latin ''axis'', "axle") or epistropheus is the second cervical vertebra (C2) of the spine, immediately inferior to the atlas, upon which the head rests. The axis' defining feature is its strong odontoid process (bony protrusion) known as the dens, which rises dorsally from the rest of the bone. Structure The body is deeper in front or in the back and is prolonged downward anteriorly to overlap the upper and front part of the third vertebra. It presents a median longitudinal ridge in front, separating two lateral depressions for the attachment of the longus colli muscles. Odontoid Process of Axis (Dens) The dens, also called the odontoid process or the peg, is the most pronounced projecting feature of the axis. The dens exhibits a slight constriction where it joins the main body of the vertebra. The condition where the dens is separated from the body of the axis is called ''os odontoideum'' and may cause nerve and circulation compression syndrome. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prodelphinidin C2
Prodelphinidin C2 is a prodelphinidin trimer found in malt Malt is germinated cereal grain that has been dried in a process known as " malting". The grain is made to germinate by soaking in water and is then halted from germinating further by drying with hot air. Malted grain is used to make beer, wh .... References External links Prodelphinidin C2 at www.phenol-explorer.eu Condensed tannins Natural phenol trimers {{aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclic Group
In group theory, a branch of abstract algebra in pure mathematics, a cyclic group or monogenous group is a group, denoted C''n'', that is generated by a single element. That is, it is a set of invertible elements with a single associative binary operation, and it contains an element ''g'' such that every other element of the group may be obtained by repeatedly applying the group operation to ''g'' or its inverse. Each element can be written as an integer power of ''g'' in multiplicative notation, or as an integer multiple of ''g'' in additive notation. This element ''g'' is called a ''generator'' of the group. Every infinite cyclic group is isomorphic to the additive group of Z, the integers. Every finite cyclic group of order ''n'' is isomorphic to the additive group of Z/''n''Z, the integers modulo ''n''. Every cyclic group is an abelian group (meaning that its group operation is commutative), and every finitely generated abelian group ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apolipoprotein C2
Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the gene. The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons Interactive pathway map See also * Apolipoprotein C In the field of molecular biology, apolipoprotein C is a family of four low molecular weight apolipoproteins, designated as C-I, C-II, C-III, and C-IV that are surface components of chylomicrons, VLDL, and HDL. In the fasting state, the C apol ... References * * * * * * * * * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
