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Nested Case–control Study
A nested case–control (NCC) study is a variation of a case–control study in which cases and controls are drawn from the population in a fully enumerated cohort. Usually, the exposure of interest is only measured among the cases and the selected controls. Thus the nested case–control study is more efficient than the full cohort design. The nested case–control study can be analyzed using methods for missing covariates. The NCC design is often used when the exposure of interest is difficult or expensive to obtain and when the outcome is rare. By utilizing data previously collected from a large cohort study, the time and cost of beginning a new case–control study is avoided. By only measuring the covariate in as many participants as necessary, the cost and effort of exposure assessment is reduced. This benefit is pronounced when the covariate of interest is biological, since assessments such as gene expression profiling are expensive, and because the quantity of blood availabl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Case–control Study
A case–control study (also known as case–referent study) is a type of observational study in which two existing groups differing in outcome are identified and compared on the basis of some supposed causal attribute. Case–control studies are often used to identify factors that may contribute to a medical condition by comparing subjects who have that condition/disease (the "cases") with patients who do not have the condition/disease but are otherwise similar (the "controls"). They require fewer resources but provide less evidence for causal inference than a randomized controlled trial. A case–control study produces only an odds ratio, which is an inferior measure of strength of association compared to relative risk. Definition The case–control is a type of epidemiological observational study. An observational study is a study in which subjects are not randomized to the exposed or unexposed groups, rather the subjects are ''observed'' in order to determine both their expos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cohort Study
A cohort study is a particular form of longitudinal study that samples a cohort (a group of people who share a defining characteristic, typically those who experienced a common event in a selected period, such as birth or graduation), performing a cross-section at intervals through time. It is a type of panel study where the individuals in the panel share a common characteristic. Cohort studies represent one of the fundamental designs of epidemiology which are used in research in the fields of medicine, pharmacy, nursing, psychology, social science, and in any field reliant on 'difficult to reach' answers that are based on evidence (statistics). In medicine for instance, while clinical trials are used primarily for assessing the safety of newly developed pharmaceuticals before they are approved for sale, epidemiological analysis on how risk factors affect the incidence of diseases is often used to identify the causes of diseases in the first place, and to help provide pre-clinica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression Profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell. Several transcriptomics technologies can be used to generate the necessary data to analyse. DNA microarrays measure the relative activity of previously identified target genes. Sequence based techniques, like RNA-Seq, provide information on the sequences of genes in addition to their expression level. Background Expression profiling is a logical next step after sequencing a genome: the sequence tells us what the cell could possibly do, while the expression profile tells us what it is actually doing at a point in time. Genes conta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nurses' Health Study
The Nurses Health Study is a series of prospective studies that examine epidemiology and the long-term effects of nutrition, hormones, environment, and nurses' work-life on health and disease development. The studies have been among the largest investigations into risk factors for major chronic diseases ever conducted. The Nurses' Health Studies have led to many insights on health and well-being, including cancer prevention, cardiovascular disease, and type 2 diabetes. They have included clinicians, epidemiologists, and statisticians at the Channing Laboratory (of Brigham and Women's Hospital), Harvard Medical School, Harvard School of Public Health, and several Harvard-affiliated hospitals, including Brigham and Women's Hospital, Dana–Farber Cancer Institute, Children's Hospital Boston, and Beth Israel Deaconess Medical Center. Cohorts The Nurses' Health Study original cohort was established in 1976 by Frank E. Speizer. Initially, the study investigated contraceptive use, smo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. The process of gene expression is used by all known life—eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conditional Logistic Regression
Conditional logistic regression is an extension of logistic regression that allows one to take into account stratification and matching. Its main field of application is observational studies and in particular epidemiology. It was devised in 1978 by Norman Breslow, Nicholas Day, Katherine Halvorsen, Ross L. Prentice and C. Sabai. It is the most flexible and general procedure for matched data. Motivation Observational studies use stratification or matching as a way to control for confounding. Several tests existed before conditional logistic regression for matched data as shown in related tests. However, they did not allow for the analysis of continuous predictors with arbitrary stratum size. All of those procedures also lack the flexibility of conditional logistic regression and in particular the possibility to control for covariates. Logistic regression can take into account stratification by having a different constant term for each stratum. Let us denote Y_\in\ the label (e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Annals Of Statistics
The ''Annals of Statistics'' is a peer-reviewed statistics journal published by the Institute of Mathematical Statistics. It was started in 1973 as a continuation in part of the '' Annals of Mathematical Statistics (1930)'', which was split into the ''Annals of Statistics'' and the ''Annals of Probability''. The journal CiteScore is 5.8, and its SCImago Journal Rank is 5.877, both from 2020. Articles older than 3 years are available on JSTOR, and all articles since 2004 are freely available on the arXiv. Editorial board The following persons have been editors of the journal: * Ingram Olkin (1972–1973) * I. Richard Savage (1974–1976) * Rupert Miller (1977–1979) * David V. Hinkley (1980–1982) * Michael D. Perlman (1983–1985) * Willem van Zwet (1986–1988) * Arthur Cohen (1988–1991) * Michael Woodroofe (1992–1994) * Larry Brown and John Rice (1995–1997) * Hans-Rudolf Künsch and James O. Berger (1998–2000) * John Marden and Jon A. Wellner (2001–2003) * M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inverse Probability Weighting
Inverse probability weighting is a statistical technique for calculating statistics standardized to a pseudo-population different from that in which the data was collected. Study designs with a disparate sampling population and population of target inference (target population) are common in application. There may be prohibitive factors barring researchers from directly sampling from the target population such as cost, time, or ethical concerns. A solution to this problem is to use an alternate design strategy, e.g. stratified sampling. Weighting, when correctly applied, can potentially improve the efficiency and reduce the bias of unweighted estimators. One very early weighted estimator is the Horvitz–Thompson estimator of the mean. When the sampling probability is known, from which the sampling population is drawn from the target population, then the inverse of this probability is used to weight the observations. This approach has been generalized to many aspects of statistics un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epidemiological Study Projects
Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare. Epidemiologists help with study design, collection, and statistical analysis of data, amend interpretation and dissemination of results (including peer review and occasional systematic review). Epidemiology has helped develop methodology used in clinical research, public health studies, and, to a lesser extent, basic research in the biological sciences. Major areas of epidemiological study include disease causation, transmission, outbreak investigation, disease surveillance, environmental epidemiology, forensic epidemiology, occupational epidemiology, screening, biomonitoring, and comparisons of treatment effects such as in clinical trials. Epid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Design Of Experiments
The design of experiments (DOE, DOX, or experimental design) is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation. The term is generally associated with experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments, in which natural conditions that influence the variation are selected for observation. In its simplest form, an experiment aims at predicting the outcome by introducing a change of the preconditions, which is represented by one or more independent variables, also referred to as "input variables" or "predictor variables." The change in one or more independent variables is generally hypothesized to result in a change in one or more dependent variables, also referred to as "output variables" or "response variables." The experimental design may also identify control variables that must be h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cohort Study Methods
Cohort or cohortes may refer to: * Cohort (educational group), a group of students working together through the same academic curriculum * Cohort (floating point), a set of different encodings of the same numerical value * Cohort (military unit), the basic tactical unit of a Roman legion * Cohort (statistics), a group of subjects with a common defining characteristic, for example age group * Cohort (taxonomy), in biology, one of the taxonomic ranks * Cohort study, a form of longitudinal study used in medicine and social science * Cohort analysis, a subset of behavioral analytics that takes the data from a given data set * Cohort Studios, a video game development company * Generational cohort, an aggregation of individuals who experience the same event within the same time interval * "Cohort", a disc golf putter by Infinite Discs Cohortes * ''Cohortes urbanae'', the riot police of Ancient Rome, also pressed into use as a military unit * Cohortes vigilum, the firefighters and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
