Naples Phlebovirus
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Naples Phlebovirus
''Naples phlebovirus'' is an antigenic species of genus ''Phlebovirus'' within the family ''Phenuiviridae'' of the order ''Bunyavirales''. It is an enveloped RNA virus with a tripartite genome e Uukuniemi (UUK) serogroup. The Sandfly group's natural reservoir are sandflies, while the natural reservoir for Uukuniemi is ticks. The SFNV serogroup consists of two main serocomplexes associated with disease in humans, the Naples and Sicilian serocomplexes. Sandfly fever induces myalgia, fever, and elevated liver enzymes in humans. It is difficult to diagnose outside endemic areas. Natural reservoir Phlebotomine sandflies (Psychodidae Psychodidae, called drain flies, sink flies, filter flies, sewer flies, or sewer gnats, is a family of true flies. Some genera have short, hairy bodies and wings giving them a "furry" moth-like appearance, hence one of their common names, moth f ...) are the natural reservoir and transmit to humans via bite. Psychodidae has a wide geographical distrib ...
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Phlebovirus
''Phlebovirus'' is one of twenty genera of the family ''Phenuiviridae'' in the order ''Bunyavirales''. The genus contains 66 species. It derives its name from Phlebotominae, the Vector (disease vector, vectors of member species ''Naples phlebovirus'', which is said to be ultimately from the Greek language, Greek , meaning "vein". The proper word for "vein" in ancient Greek is however ''phleps'' (φλέψ). Virology Phleboviruses are viruses with a negative-sense RNA genome consisting of three segments. The small segment (S) codes for the viral N protein and a non structural protein, NSs via an ambisense coding strategy. The medium-sized segment (M) codes for a precursor of the viral glycoproteins and non-structural components. The product of the largest segment (L) is the viral RNA-dependent RNA polymerase. Replication The Phlebovirus replicates in a 7 step process. First, the cellular attachment is driven through the glycoprotein interactions with host cells. Examples of this ...
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Phenuiviridae
''Phenuiviridae'' is a family of negative-strand RNA viruses in the order ''Bunyavirales''. Ruminants, camels, humans, and mosquitoes serve as natural hosts. Member genus ''Phlebovirus'' is the only genus of the family that has viruses that cause disease in humans (e.g. Rift Valley fever virus) except Dabie bandavirus. Virology Structure Members of ''Phenuiviridae are'' enveloped viruses with helical capsid morphology. Envelope glycoproteins of these viruses are distributed with icosahedral symmetry (T=12). Genome ''Phenuiviridae'' is a negative-sense single-stranded RNA virus family. Its genome is segmented into three pieces: L segment (encoding RNA-dependent RNA polymerase), M segment, and S segment. Some members of the family have ambisense gene encoding on the S segment ( nucleocapsid proteins). The M segment includes envelope glycoproteins encoded in a polyprotein that is cleaved by host proteases. Multiple different proteins can be encoded on the M segment due ...
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Bunyavirales
''Bunyavirales'' is an order of segmented negative-strand RNA viruses with mainly tripartite genomes. Member viruses infect arthropods, plants, protozoans, and vertebrates. It is the only order in the class ''Ellioviricetes''. The name ''Bunyavirales'' derives from Bunyamwera, where the original type species ''Bunyamwera orthobunyavirus'' was first discovered. ''Ellioviricetes'' is named in honor of late virologist Richard M. Elliott for his early work on bunyaviruses. Bunyaviruses belong to the fifth group of the Baltimore classification system, which includes viruses with a negative-sense, single-stranded RNA genome. They have an enveloped, spherical virion. Though generally found in arthropods or rodents, certain viruses in this order occasionally infect humans. Some of them also infect plants. In addition, there is a group of bunyaviruses whose replication is restricted to arthropods and is known as insect-specific bunyaviruses. A majority of bunyaviruses are vector-borne ...
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Sandflies
Sandfly (or sand fly) is a colloquial name for any species or genus of flying, biting, blood-sucking dipteran (fly) encountered in sandy areas. In the United States, ''sandfly'' may refer to certain horse flies that are also known as "greenheads" (family Tabanidae), or to members of the family Ceratopogonidae. The bites usually result in a small, intensely itchy bump or welt, the strength of which intensifies over a period of 5-7 days before dissipating. Moderate relief is achieved with varying success through the application of over the counter products such as Benadryl (ingested) or an analgesic cream such as After Bite (applied topically). Outside the United States, ''sandfly'' may refer to members of the subfamily Phlebotominae within the Psychodidae. Biting midges (Ceratopogonidae) are sometimes called sandflies or no-see-ums (no-see-em, noseeum). New Zealand sandflies are in the genus ''Austrosimulium'', a type of black fly. In the various sorts of sandfly only the fema ...
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Uukuniemi
Uukuniemi is a former municipality of Finland. It was located in the province of Southern Finland and was part of the South Karelia region. The municipality had a population of 516 (2003) and it covered an area of 156.58 km² of which 54.88 km² was water. The population density was 5.1 inhabitants per km². The village of Niukkala was the former administrative center of Uukuniemi. The municipality was unilingually Finnish. It was annexed with municipalities of Saari and Parikkala Parikkala () is a municipality of Finland located in the province of Southern Finland and is part of the South Karelia region, from Lappeenranta and from Joensuu. The town center of Parikkala is about from the Russian border. The municipality ... on January 1, 2005. The new municipality was named Parikkala. External links Parikkala, Saari and Uukuniemi Former municipalities of Finland Parikkala Populated places disestablished in 2005 2005 disestablishments in Finland ...
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Pappataci Fever
Pappataci fever (also known as Phlebotomus fever and, somewhat confusingly, sandfly fever and three-day fever) is a vector-borne febrile arboviral infection caused by three serotypes of Phlebovirus. It occurs in subtropical regions of the Eastern Hemisphere. The name, pappataci fever, comes from the Italian word for sandfly; it is the union of the words ''pappa'' (usually this is used as a generic name for food, but in this case it is a ''verb'' meaning "eating") and ''taci'' (silent), distinguishing these insects from blood-feeding mosquitoes, which produce a typical noise while flying. Signs and symptoms A few days after the infective bite, a feeling of lassitude, abdominal distress and chills develop followed by fever of , severe frontal headaches, muscle and joint aches, flushing of the face and a fast heart rate. After two days the fever begins to subside and the temperature returns to normal. Fatigue, a slow heart rate and low blood pressure may persist from a few days to se ...
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Phlebotomine
The Phlebotominae are a subfamily of the family Psychodidae. In several countries, their common name is sandfly; but that name is also applied to other flies. The Phlebotominae include many genera of blood-feeding (hematophagous) flies, including the primary vectors of leishmaniasis, bartonellosis and pappataci fever. In the New World, leishmaniasis is spread by sand flies in the genus ''Lutzomyia'', which commonly live in caves, where their main hosts are bats. In the Old World, sand flies in the genus ''Phlebotomus'' spread leishmaniasis. Phlebotomine females, and only females, suck blood from various mammals, reptiles and birds. Some species are selective, whereas others bite any suitable host they find. Some species can produce one clutch of eggs before their first blood meal; such females are said to practise autogenous or partly autogenous reproduction. Other species need a blood meal before they can produce any eggs at all; they are said to practise anautogenous reproduct ...
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Psychodidae
Psychodidae, called drain flies, sink flies, filter flies, sewer flies, or sewer gnats, is a family of true flies. Some genera have short, hairy bodies and wings giving them a "furry" moth-like appearance, hence one of their common names, moth flies. Members of the sub-family Phlebotominae which are hematophagous (feed on blood) may be called sand flies in some countries, although this term is also used for other unrelated flies. There are more than 2,600 described species worldwide, most of them native to the humid tropics. This makes them one of the most diverse families of their order. Drain flies sometimes inhabit plumbing drains and sewage systems, where they are harmless, but may be a persistent annoyance. Life cycle The larvae of the subfamilies Psychodinae, Sycoracinae and Horaiellinae live in aquatic to semi-terrestrial or sludge-based habitats, including bathroom sinks, where they feed on bacteria and can become problematic. The larvae of the most commonly encou ...
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