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NEJM
''The New England Journal of Medicine'' (''NEJM'') is a weekly medical journal published by the Massachusetts Medical Society. It is among the most prestigious peer-reviewed medical journals as well as the oldest continuously published one. History In September 1811, John Collins Warren, a Boston physician, along with James Jackson, submitted a formal prospectus to establish the ''New England Journal of Medicine and Surgery and Collateral Branches of Science'' as a medical and philosophical journal. Subsequently, the first issue of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' was published in January 1812. The journal was published quarterly. In 1823, another publication, the ''Boston Medical Intelligencer'', appeared under the editorship of Jerome V. C. Smith. The editors of the ''New England Journal of Medicine and Surgery and the Collateral Branches of Medical Science'' purchased the weekly ''Intelligencer'' for $600 in 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated. In most cases, the cause is unknown. Genetic risk factors may include Down syndrome, Li-Fraumeni syndrome, or neurofibromatosis type 1. Environmental risk factors may include significant radiation exposure or prior chemotherapy. Evidence regarding electromagnetic fields or pesticides is unclear. Some hypothesize that an abnormal immune response to a common infection may be a trigger. The underlying mechanism involves multiple genetic mutations that results in rapid cell division. The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical Industry
The pharmaceutical industry discovers, develops, produces, and markets drugs or pharmaceutical drugs for use as medications to be administered to patients (or self-administered), with the aim to cure them, vaccinate them, or alleviate symptoms. Pharmaceutical companies may deal in generic or brand medications and medical devices. They are subject to a variety of laws and regulations that govern the patenting, testing, safety, efficacy using drug testing and marketing of drugs. The global pharmaceuticals market produced treatments worth $1,228.45 billion in 2020 and showed a compound annual growth rate (CAGR) of 1.8%. History Mid-1800s – 1945: From botanicals to the first synthetic drugs The modern era of pharmaceutical industry began with local apothecaries that expanded from their traditional role of distributing botanical drugs such as morphine and quinine to wholesale manufacture in the mid-1800s, and from discoveries resulting from applied research. Intentional drug ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Henry Jacob Bigelow
Henry Jacob Bigelow (March 11, 1818October 30, 1890) was an American surgeon and Professor of Surgery at Harvard University. A dominating figure in Boston medicine for many decades, he is remembered for the Bigelow maneuver for hip dislocation, a technique for treatment of kidney stones, and other innovations. He was instrumental in bringing the anesthetic possibilities of ether to the attention of medical men, and rescuing the case of Phineas Gage from relative obscurity. He was a vocal opponent of vivisection, and played a minor role in the apprehension of the culprit in the Parkman–Webster murder case. Biography Bigelow was born March 11, 1818 in Boston to his mother, Mary Scollay, and his father, Jacob Bigelow who taught medicine at Harvard. Bigelow entered Harvard College at fifteen years old and, after a not entirely smooth undergraduate career (including an incident in which he discharged a musket in his Hollis Hall room) graduated in 1837. He studied medicine both at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Addiction Rare In Patients Treated With Narcotics
"Addiction Rare in Patients Treated with Narcotics" is the title of a letter to the editor written by Jane Porter and Hershel Jick and published in the January 10, 1980, issue of ''The New England Journal of Medicine''. The letter analyzed data on patients who had been treated with opioids in a hospital setting, and concluded that addiction was uncommon among such patients. It has since been frequently misrepresented to claim that opioids are not addictive when prescribed for use at home, which has been blamed for contributing to the opioid epidemic in the United States. Content The letter reported on an examination of medical files of patients who had been hospitalized and treated with small doses of opioids. The authors concluded that of the 11,882 patients who received at least one narcotic drug, only four of them had developed a "reasonably well documented" addiction among patients who had no history of addiction. Its text read, in its entirety: Influence The article was subseq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Folic Acid
Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and storage. Folate is required for the body to make DNA and RNA and metabolise amino acids necessary for cell division. As humans cannot make folate, it is required in the diet, making it an essential nutrient. It occurs naturally in many foods. The recommended adult daily intake of folate in the U.S. is 400 micrograms from foods or dietary supplements. Folate in the form of folic acid is used to treat anemia caused by folate deficiency. Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in the baby. Low levels in early pregnancy are believed to be the cause of more than half of babies born with NTDs. More than 80 countries use either mandatory or voluntary fortification of c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Platelets
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot. Platelets have no cell nucleus; they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow or lung, which then enter the circulation. Platelets are found only in mammals, whereas in other vertebrates (e.g. birds, amphibians), thrombocytes circulate as intact mononuclear cells. One major function of platelets is to contribute to hemostasis: the process of stopping bleeding at the site of interrupted endothelium. They gather at the site and, unless the interruption is physically too large, they plug the hole. First, platelets attach to substances outside the interrupted endothelium: ''adhesion''. Second, they change shape, turn on receptors and secrete chemical messengers: ''activatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Megakaryocytes
A megakaryocyte (''mega-'' + '' karyo-'' + '' -cyte'', "large-nucleus cell") is a large bone marrow cell with a lobated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting. In humans, megakaryocytes usually account for 1 out of 10,000 bone marrow cells, but can increase in number nearly 10-fold during the course of certain diseases. Owing to variations in combining forms and spelling, synonyms include megalokaryocyte and megacaryocyte. Structure In general, megakaryocytes are 10 to 15 times larger than a typical red blood cell, averaging 50–100 μm in diameter. During its maturation, the megakaryocyte grows in size and replicates its DNA without cytokinesis in a process called endomitosis. As a result, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei. In some cases, the nucleus may contain up to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Colonoscope
Colonoscopy () or coloscopy () is the endoscopic examination of the large bowel and the distal part of the small bowel with a CCD camera or a fiber optic camera on a flexible tube passed through the anus. It can provide a visual diagnosis (''e.g.,'' ulceration, polyps) and grants the opportunity for biopsy or removal of suspected colorectal cancer lesions. Colonoscopy can remove polyps smaller than one millimeter. Once polyps are removed, they can be studied with the aid of a microscope to determine if they are precancerous or not. Colonoscopy is similar to sigmoidoscopy—the difference being related to which parts of the colon each can examine. A colonoscopy allows an examination of the entire colon (1,200–1,500mm in length). A sigmoidoscopy allows an examination of the distal portion (about 600mm) of the colon, which may be sufficient because benefits to cancer survival of colonoscopy have been limited to the detection of lesions in the distal portion of the colon. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminopterin
Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities. Uses Discovered by Yellapragada Subbarow, the drug was first used by Sidney Farber in 1947 to induce remissions among children with leukemia. Aminopter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eric Rubin
Eric J. Rubin is an American microbiologist, infectious disease specialist, and is currently the editor-in-chief of the ''New England Journal of Medicine''. He is also an adjunct professor of immunology and infectious diseases and was formerly the Irene Heinz Given Professor and chair of the department of immunology and infectious diseases at the Harvard T.H. Chan School of Public Health. His research laboratory works on ''Mycobacterium tuberculosis'', nontuberculous mycobacteria (NTMs), and the development and application of bacterial genetics tools to study the fundamental biology of these pathogenic organisms. He holds an M.D. from the School of Medicine as well as a Ph.D. from the Graduate School of Biomedical Sciences at Tufts University Tufts University is a private research university on the border of Medford and Somerville, Massachusetts. It was founded in 1852 as Tufts College by Christian universalists who sought to provide a nonsectarian institution of higher lea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts Medical Society
The Massachusetts Medical Society (MMS) is the oldest continuously operating state medical association in the United States. Incorporated on November 1, 1781, by an act of the Massachusetts General Court, the MMS is a non-profit organization that consists of more than 25,000 physicians, medical students and residents. It is currently based in Waltham, Massachusetts. The majority of the members live or practice in Massachusetts and the immediate vicinity. Publication The Massachusetts Medical Society is the owner and publisher of the ''New England Journal of Medicine'', which is the most widely read and cited medical journal in the world. The ''New England Journal of Medicine'' is also the oldest continuously published and circulating medical journal in the world and has an impact factor of 91.2, which is the highest among all the medical journals in the world. It also publishes the Journal Watch family of professional newsletters. NEJM Journal Watch publishes the following t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quill
A quill is a writing tool made from a moulted flight feather (preferably a primary wing-feather) of a large bird. Quills were used for writing with ink before the invention of the dip pen, the metal- nibbed pen, the fountain pen, and, eventually, the ballpoint pen. As with the earlier reed pen (and later dip pen), a quill has no internal ink reservoir and therefore needs to periodically be dipped into an inkwell during writing. The hand-cut goose quill is rarely used as a calligraphy tool anymore because many papers are now derived from wood pulp and would quickly wear a quill down. However, it is still the tool of choice for a few scribes who have noted that quills provide an unmatched sharp stroke as well as greater flexibility than a steel pen. Description The shaft of a flight feather is long and hollow, making it an obvious candidate for being crafted into a pen. The process of making a quill from a feather involves curing the shaft to harden it, then fashioning its tip ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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