NAPE-PLD
NAPE-PLD may refer to: * N-acyl phosphatidylethanolamine-specific phospholipase D, an enzyme * N-acetylphosphatidylethanolamine-hydrolysing phospholipase D, an enzyme {{Short pages monitor ...
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N-acyl Phosphatidylethanolamine-specific Phospholipase D
N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) is an enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE). This is a major part of the process that converts ordinary lipids into chemical signals like anandamide and oleoylethanolamine. In humans, the NAPE-PLD protein is encoded by the ''NAPEPLD'' gene.See for in-depth coverage. Discovery NAPE-PLD is an enzyme activity - a phospholipase, acting on phospholipids found in the cell membrane. It is not homology but the chemical outcome of its activity that classes it as phospholipase D. The enzymatic activity was discovered and characterized in a series of experiments culminating in the 2004 publication of a biochemical purification scheme from which peptide sequencing could be accomplished. Researchers homogenized (finely ground) hearts from 150 rats and subjected the resulting crude lysate to sucrose sedimentation at 105,000 x g to separate out the cell membr ...
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