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Neuronal Lineage Marker
A neuronal lineage marker is an endogenous tag that is expressed in different cells along neurogenesis and differentiated cells such as neurons. It allows detection and identification of cells by using different techniques. A neuronal lineage marker can be either DNA, mRNA or RNA expressed in a cell of interest. It can also be a protein tag, as a partial protein, a protein or an epitope that discriminates between different cell types or different states of a common cell. An ideal marker is specific to a given cell type in normal conditions and/or during injury. Cell markers are very valuable tools for examining the function of cells in normal conditions as well as during disease. The discovery of various proteins specific to certain cells led to the production of cell-type-specific antibodies that have been used to identify cells. The techniques used for its detection can be immunohistochemistry, immunocytochemistry, methods that utilize transcriptional modulators and site-specif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurogenesis
Neurogenesis is the process by which nervous system cells, the neurons, are produced by neural stem cells (NSCs). It occurs in all species of animals except the porifera (sponges) and placozoans. Types of NSCs include neuroepithelial cells (NECs), radial glial cells (RGCs), basal progenitors (BPs), intermediate neuronal precursors (INPs), subventricular zone astrocytes, and subgranular zone radial astrocytes, among others. Neurogenesis is most active during embryonic development and is responsible for producing all the various types of neurons of the organism, but it continues throughout adult life in a variety of organisms. Once born, neurons do not divide (see mitosis), and many will live the lifespan of the animal. Neurogenesis in mammals Developmental neurogenesis During embryonic development, the mammalian central nervous system (CNS; brain and spinal cord) is derived from the neural tube, which contains NSCs that will later generate neurons. However, neurogenesis does ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camillo Golgi
Camillo Golgi (; 7 July 184321 January 1926) was an Italian biologist and pathologist known for his works on the central nervous system. He studied medicine at the University of Pavia (where he later spent most of his professional career) between 1860 and 1868 under the tutelage of Cesare Lombroso. Inspired by pathologist Giulio Bizzozero, he pursued research in the nervous system. His discovery of a staining technique called black reaction (sometimes called Golgi's method or Golgi's staining in his honour) in 1873 was a major breakthrough in neuroscience. Several structures and phenomena in anatomy and physiology are named for him, including the Golgi apparatus, the Golgi tendon organ and the Golgi tendon reflex. Golgi and the Spanish biologist Santiago Ramón y Cajal were jointly given the Nobel Prize in Physiology or Medicine 1906 "in recognition of their work on the structure of the nervous system". Biography Camillo Golgi was born on 7 July 1843 in the village of Corteno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibodies
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs in a few vari ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Coons
Albert Hewett Coons (June 28, 1912 – September 30, 1978) was an American physician, pathologist, and immunologist. He was the first person to conceptualize and develop immunofluorescent techniques for labeling antibodies in the early 1940s. Early years Coons was born in Gloversville, New York, on June 28, 1912, the son of Albert Selmser and Marion (née Hewett) Coons. His father was the president of a glove-manufacturing company, and his grandfather, Eugene Coons, was a physician. He was educated in Gloversville public schools, graduated with a B.S. from Williams College (Williamstown, Massachusetts) in 1933, and received his M.D. degree from Harvard Medical School in 1937.McDevitt, H. OAlbert Hewett Coons ''Biographical memoirs of the National Academy of Sciences. Thereafter, Albert pursued residency training in internal medicine at Massachusetts General Hospital in Boston, Massachusetts. During the final years of his house-officership, Coons joined the Thorndike Memo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hippocampus
The hippocampus (via Latin from Greek , 'seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, and plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation. The hippocampus is located in the allocortex, with neural projections into the neocortex in humans, as well as primates. The hippocampus, as the medial pallium, is a structure found in all vertebrates. In humans, it contains two main interlocking parts: the hippocampus proper (also called ''Ammon's horn''), and the dentate gyrus. In Alzheimer's disease (and other forms of dementia), the hippocampus is one of the first regions of the brain to suffer damage; short-term memory loss and disorientation are included among the early symptoms. Damage to the hippocampus can also result from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebellum
The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as or even larger. In humans, the cerebellum plays an important role in motor control. It may also be involved in some cognition, cognitive functions such as attention and language as well as emotion, emotional control such as regulating fear and pleasure responses, but its movement-related functions are the most solidly established. The human cerebellum does not initiate movement, but contributes to Motor coordination, coordination, precision, and accurate timing: it receives input from sensory systems of the spinal cord and from other parts of the brain, and integrates these inputs to fine-tune motor activity. Cerebellar damage produces disorders in Fine motor skill, fine movement, Equilibrioception, equilibrium, Human positions, posture, and motor learning in humans. Anatomica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Purkinje Cells
Purkinje cells, or Purkinje neurons, are a class of GABAergic inhibitory neurons located in the cerebellum. They are named after their discoverer, Czech anatomist Jan Evangelista Purkyně, who characterized the cells in 1839. Structure These cells are some of the largest neurons in the human brain (Betz cells being the largest), with an intricately elaborate dendritic arbor, characterized by a large number of dendritic spines. Purkinje cells are found within the Purkinje layer in the cerebellum. Purkinje cells are aligned like dominos stacked one in front of the other. Their large dendritic arbors form nearly two-dimensional layers through which parallel fibers from the deeper-layers pass. These parallel fibers make relatively weaker excitatory (glutamatergic) synapses to spines in the Purkinje cell dendrite, whereas climbing fibers originating from the inferior olivary nucleus in the medulla provide very powerful excitatory input to the proximal dendrites and cell soma. P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroanatomy
Neuroanatomy is the study of the structure and organization of the nervous system. In contrast to animals with radial symmetry, whose nervous system consists of a distributed network of cells, animals with bilateral symmetry have segregated, defined nervous systems. Their neuroanatomy is therefore better understood. In vertebrates, the nervous system is segregated into the internal structure of the brain and spinal cord (together called the central nervous system, or CNS) and the routes of the nerves that connect to the rest of the body (known as the peripheral nervous system, or PNS). The delineation of distinct structures and regions of the nervous system has been critical in investigating how it works. For example, much of what neuroscientists have learned comes from observing how damage or "lesions" to specific brain areas affects behavior or other neural functions. For information about the composition of non-human animal nervous systems, see nervous system. For information ab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Santiago Ramon Y Cajal
Santiago (, ; ), also known as Santiago de Chile, is the capital and largest city of Chile as well as one of the largest cities in the Americas. It is the center of Chile's most densely populated region, the Santiago Metropolitan Region, whose total population is 8 million which is nearly 40% of the country's population, of which more than 6 million live in the city's continuous urban area. The city is entirely in the country's central valley. Most of the city lies between above mean sea level. Founded in 1541 by the Spanish conquistador Pedro de Valdivia, Santiago has been the capital city of Chile since colonial times. The city has a downtown core of 19th-century neoclassical architecture and winding side-streets, dotted by art deco, neo-gothic, and other styles. Santiago's cityscape is shaped by several stand-alone hills and the fast-flowing Mapocho River, lined by parks such as Parque Forestal and Balmaceda Park. The Andes Mountains can be seen from most point ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nissl Staining
Franz Alexander Nissl (9 September 1860, in Frankenthal – 11 August 1919, in Munich) was a German psychiatrist and medical researcher. He was a noted neuropathologist. Early life Nissl was born in Frankenthal to Theodor Nissl and Maria Haas. Theodor taught Latin in a Catholic school and wanted Franz to become a priest. However Franz entered the Ludwig Maximilian University of Munich to study medicine. Later, he specialized in Psychiatry. One of Nissl's university professors was Bernhard von Gudden. His assistant, Sigbert Josef Maria Ganser suggested that Nissl write an essay on the pathology of the cells of the cortex of the brain. When the medical faculty offered a competition for a prize in neurology in 1884, Nissl undertook the brain-cortex study. He used alcohol as a fixative and developed a staining technique that allowed the demonstration of several new nerve-cell constituents. Nissl won the prize, and wrote his doctoral dissertation on the same topic in 1885. Car ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franz Nissl
Franz Alexander Nissl (9 September 1860, in Frankenthal – 11 August 1919, in Munich) was a German psychiatrist and medical researcher. He was a noted neuropathologist. Early life Nissl was born in Frankenthal to Theodor Nissl and Maria Haas. Theodor taught Latin in a Catholic school and wanted Franz to become a priest. However Franz entered the Ludwig Maximilian University of Munich to study medicine. Later, he specialized in Psychiatry. One of Nissl's university professors was Bernhard von Gudden. His assistant, Sigbert Josef Maria Ganser suggested that Nissl write an essay on the pathology of the cells of the cortex of the brain. When the medical faculty offered a competition for a prize in neurology in 1884, Nissl undertook the brain-cortex study. He used alcohol as a fixative and developed a staining technique that allowed the demonstration of several new nerve-cell constituents. Nissl won the prize, and wrote his doctoral dissertation on the same topic in 1885. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Golgi II
In neuroscience, Golgi cells are inhibitory interneurons found within the granular layer of the cerebellum. They were first identified as inhibitory in 1964. It was also the first example of an inhibitory feedback network, where the inhibitory interneuron was identified anatomically. These cells synapse onto the dendrite of granule cells and unipolar brush cells. They receive excitatory input from mossy fibres, also synapsing on granule cells, and parallel fibers, which are long granule cell axons. Thereby this circuitry allows for feed-forward and feed-back inhibition of granule cells. The main synapse made by these cells is a synapse onto the mossy fibre - granule cell excitatory synapse in a glomerulus. The glomerulus is made up of the mossy fibre terminal, granule cell dendrites, the Golgi terminal and is enclosed by a glial coat. The Golgi cell acts by altering the mossy fibre - granule cell synapse. The Golgi cells use GABA as their neurotransmitter. The basal level of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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