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Network Motif
Network motifs are recurrent and statistically significant Subgraph (graph theory), subgraphs or patterns of a larger complex network, graph. All networks, including biological networks, social networks, technological networks (e.g., computer networks and electrical circuits) and more, can be represented as graphs, which include a wide variety of subgraphs. Network motifs are sub-graphs that repeat themselves in a specific network or even among various networks. Each of these sub-graphs, defined by a particular pattern of interactions between vertices, may reflect a framework in which particular functions are achieved efficiently. Indeed, motifs are of notable importance largely because they may reflect functional properties. They have recently gathered much attention as a useful concept to uncover structural design principles of complex networks. Although network motifs may provide a deep insight into the network's functional abilities, their detection is computationally challengi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistically Significant
In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis (simply by chance alone). More precisely, a study's defined significance level, denoted by \alpha, is the probability of the study rejecting the null hypothesis, given that the null hypothesis is true; and the p-value, ''p''-value of a result, ''p'', is the probability of obtaining a result at least as extreme, given that the null hypothesis is true. The result is statistically significant, by the standards of the study, when p \le \alpha. The significance level for a study is chosen before data collection, and is typically set to 5% or much lower—depending on the field of study. In any experiment or Observational study, observation that involves drawing a Sampling (statistics), sample from a Statistical population, population, there is always the possibility that an observed effect would have occurred due to sampling error alone. But if the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Pattern Tree In FPF Algorithm
''The'' () is a grammatical Article (grammar), article in English language, English, denoting persons or things that are already or about to be mentioned, under discussion, implied or otherwise presumed familiar to listeners, readers, or speakers. It is the definite article in English. ''The'' is the Most common words in English, most frequently used word in the English language; studies and analyses of texts have found it to account for seven percent of all printed English-language words. It is derived from gendered articles in Old English which combined in Middle English and now has a single form used with nouns of any gender. The word can be used with both singular and plural nouns, and with a noun that starts with any letter. This is different from many other languages, which have different forms of the definite article for different genders or numbers. Pronunciation In most dialects, "the" is pronounced as (with the voiced dental fricative followed by a schwa) when fol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Graphical Model
A graphical model or probabilistic graphical model (PGM) or structured probabilistic model is a probabilistic model for which a Graph (discrete mathematics), graph expresses the conditional dependence structure between random variables. They are commonly used in probability theory, statistics—particularly Bayesian statistics—and machine learning. Types of graphical models Generally, probabilistic graphical models use a graph-based representation as the foundation for encoding a distribution over a multi-dimensional space and a graph that is a compact or Factor graph, factorized representation of a set of independences that hold in the specific distribution. Two branches of graphical representations of distributions are commonly used, namely, Bayesian networks and Markov random fields. Both families encompass the properties of factorization and independences, but they differ in the set of independences they can encode and the factorization of the distribution that they induce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clique (graph Theory)
In the mathematical area of graph theory, a clique ( or ) is a subset of vertices of an undirected graph such that every two distinct vertices in the clique are adjacent. That is, a clique of a graph G is an induced subgraph of G that is complete. Cliques are one of the basic concepts of graph theory and are used in many other mathematical problems and constructions on graphs. Cliques have also been studied in computer science: the task of finding whether there is a clique of a given size in a graph (the clique problem) is NP-complete, but despite this hardness result, many algorithms for finding cliques have been studied. Although the study of complete subgraphs goes back at least to the graph-theoretic reformulation of Ramsey theory by , the term ''clique'' comes from , who used complete subgraphs in social networks to model cliques of people; that is, groups of people all of whom know each other. Cliques have many other applications in the sciences and particularly in bioinf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Regulatory Network
A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell. GRN also play a central role in morphogenesis, the creation of body structures, which in turn is central to evolutionary developmental biology (evo-devo). The regulator can be DNA, RNA, protein or any combination of two or more of these three that form a complex, such as a specific sequence of DNA and a transcription factor to activate that sequence. The interaction can be direct or indirect (through transcribed RNA or translated protein). In general, each mRNA molecule goes on to make a specific protein (or set of proteins). In some cases this protein will be Protein#Structural proteins, structural, and will accumulate at the cell membrane or within the cell to give it particular structural properties. In other cases th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
OR Gate
The OR gate is a digital logic gate that implements logical disjunction. The OR gate returns true if either or both of its inputs are true; otherwise it returns false. The input and output states are normally represented by different voltage levels. Description The gate accepts two inputs. It outputs a 1 if either or both of these inputs are 1, or outputs a 0 only if both inputs are 0. The inputs and outputs are binary digits (" bits") which have two possible logical states. In addition to 1 and 0, these states may be called true and false, high and low, active and inactive, or other such pairs of symbols. Thus it performs logical disjunction (∨) from mathematical logic. The gate can be represented with the plus sign (+) because it can be used for logical addition. Equivalently, an OR gate finds the ''maximum'' between two binary digits, just as the AND gate finds the ''minimum''. Together with the AND gate and the NOT gate, the OR gate is one of three basic logic gate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AND Gate
The AND gate is a basic digital logic gate that implements logical conjunction (∧) from mathematical logic AND gate behaves according to the truth table. A HIGH output (1) results only if all the inputs to the AND gate are HIGH (1). If not all inputs to the AND gate are HIGH, LOW output results. The function can be extended to any number of inputs. Symbols There are three symbols for AND gates: the American (ANSI or 'military') symbol and the IEC ('European' or 'rectangular') symbol, as well as the deprecated DIN symbol. Additional inputs can be added as needed. For more information see Logic gate symbols article. It can also be denoted as symbol "^" or "&". The AND gate with inputs ''A'' and ''B'' and output ''C'' implements the logical expression C = A \cdot B. This expression also may be denoted as C=A \wedge B or C=A \And B. Implementations An AND gate can be designed using only N-channel (pictured) or P-channel MOSFETs, but is usually implemented with both (CMOS). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Feed-forward Motif
Feedforward is the provision of context of what one wants to communicate prior to that communication. In purposeful activity, feedforward creates an expectation which the actor anticipates. When expected experience occurs, this provides confirmatory feedback. Etymology The term was developed by I. A. Richards when he participated in the 8th Macy conference. I. A. Richards was a literary critic with a particular interest in rhetoric. Pragmatics is a subfield within linguistics which focuses on the use of context to assist meaning. In the context of the Macy Conference, Richards remarked "Feedforward, as I see it, is the reciprocal, the necessary condition of what the cybernetics and automation people call 'feedback'."Richards, I. A. (1952). Communication Between Men: The Meaning of Language. In Heinz von Foerster (ed), Transactions of 8th Macy Conference - Cybernetics: Circular Causal and Feedback Mechanisms in Biological and Social System. New York: Josiah Macy, Jr. Foundation. R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autoregulation Motif
Autoregulation is a process within many biological systems, resulting from an internal adaptive mechanism that works to adjust (or mitigate) that system's response to stimuli. While most systems of the body show some degree of autoregulation, it is most clearly observed in the kidney, the heart, and the brain. Perfusion of these organs is essential for life, and through autoregulation the body can divert blood (and thus, oxygen) where it is most needed. Cerebral autoregulation More so than most other organs, the brain is very sensitive to increased or decreased blood flow, and several mechanisms (metabolic, myogenic, and neurogenic) are involved in maintaining an appropriate cerebral blood pressure. Brain blood flow autoregulation is abolished in several disease states such as traumatic brain injury, stroke, brain tumors, or persistent abnormally high levels. Homeometrics and heterometric autoregulation of the heart Homeometric autoregulation, in the context of the circulato ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Regulatory Networks
A gene (or genetic) regulatory network (GRN) is a collection of molecular regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins which, in turn, determine the function of the cell. GRN also play a central role in morphogenesis, the creation of body structures, which in turn is central to evolutionary developmental biology (evo-devo). The regulator can be DNA, RNA, protein or any combination of two or more of these three that form a complex, such as a specific sequence of DNA and a transcription factor to activate that sequence. The interaction can be direct or indirect (through transcribed RNA or translated protein). In general, each mRNA molecule goes on to make a specific protein (or set of proteins). In some cases this protein will be Protein#Structural proteins, structural, and will accumulate at the cell membrane or within the cell to give it particular structural properties. In other cases th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Expansion Tree
Expansion may refer to: Arts, entertainment and media * ''L'Expansion'', a French monthly business magazine * ''Expansion'' (album), by American jazz pianist Dave Burrell, released in 2004 * ''Expansions'' (McCoy Tyner album), 1970 * ''Expansions'' (Lonnie Liston Smith album), 1975 * ''Expansión'' (Mexico), a Mexican news portal linked to CNN * Expansion (sculpture) (2004) Bronze sculpture illuminated from within * ''Expansión'' (Spanish newspaper), a Spanish economic daily newspaper published in Spain * Expansion pack in gaming, extra content for games, often simply "expansion" Science, technology, and mathematics * Expansion (geometry), stretching of geometric objects with flat sides * Expansion (model theory), in mathematical logic, a mutual converse of a reduct * Expansion card, in computing, a printed circuit board that can be inserted into an expansion slot * Expansion chamber, on a two-stroke engine, a tuned exhaust system that enhances power output * Expansion joint, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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