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Monell Chemical Senses Center
The Monell Chemical Senses Center is a non-profit independent scientific institute located at the University City Science Center campus in Philadelphia, in Pennsylvania. Monell conducts and publishes interdisciplinary basic research on taste, Olfaction, smell, and chemesthesis (chemically mediated skin senses, such as the burn of capsaicin or the tingle of carbonation). Overview Monell was founded in 1968. The center's mission is to advance knowledge of the mechanisms and functions of the chemical senses. Knowledge gained from Monell’s research is relevant to issues related to public health, national health policy, and quality of life, including studies of obesity, diabetes, hypertension, pediatric health, occupational safety, environmental interactions, and national defense. Monell has a staff of more than 50 scientists and provides research opportunities for local high school and undergraduate students. Situated in Philadelphia’s University City Science Center, the center o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robert Margolskee
Robert F. Margolskee is an American academic. He is the director of the Monell Chemical Senses Center and adjunct professor in the Department of Neuroscience at the Mount Sinai School of Medicine. Margolskee is also the a co-founder of Redpoint Bio. Margolskee has been a pioneer in the application of molecular biology and transgenic animal models to the study of taste transduction and chemosensation. He has made numerous seminal discoveries in the taste field, including the identification and molecular cloning of taste specific receptors, G proteins, channels and other taste signal transduction elements. Early life and education Margolskee received his A.B. in biochemistry and molecular biology from Harvard University. He received his an M.D. and a Ph.D in molecular genetics from Johns Hopkins University, where he studied with the late Nobel laureate Daniel Nathans. He carried out postdoctoral studies in biochemistry at Stanford University with Nobel laureate Paul Berg. Career M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Diabetes And Digestive And Kidney Diseases
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is part of the United States National Institutes of Health, which in turn is part of the Department of Health and Human Services. NIDDK is approximately the fifth-largest of the 27 NIH institutes. The institute's mission is to support research, training, and communication with the public in the topic areas of "diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases". As of 2021, the Director of the institute is Griffin P. Rodgers, who assumed the position on an acting basis in 2006 and on a permanent basis in 2007. Mission The mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct and support medical research and research training and to disseminate science-based information on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritiona ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Preti
George Preti (October 7, 1944 – March 3, 2020) was an analytical organic chemist who worked at the Monell Chemical Senses Center in Philadelphia, Pennsylvania. For more than four decades, his research focused on the nature, origin, and functional significance of human odors. Dr. Preti's laboratory has identified characteristic underarm odorants, and his later studies centered upon a bioassay-guided approach to the identification of human pheromones, odors diagnostic of human disease, human malodor identification and suppression and examining the “odor-print” of humans. Early life and education Preti was born and raised in Brooklyn, New York. He received his B.S. in chemistry from the Polytechnic Institute of Brooklyn in 1966. He earned a Ph.D. in organic chemistry in 1971 from the Massachusetts Institute of Technology, with a specialty in organic mass spectrometry in the laboratory of Professor Klaus Biemann. That same year he joined the Monell Center. Career Preti was al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Julie Mennella
Julie Mennella is a biopsychologist specializing in the development of food and flavor preferences in humans and the effects of alcohol and tobacco on women's health and infant development. She currently works at the Monell Chemical Senses Center in Philadelphia Philadelphia, often called Philly, is the largest city in the Commonwealth of Pennsylvania, the sixth-largest city in the U.S., the second-largest city in both the Northeast megalopolis and Mid-Atlantic regions after New York City. Sinc ..., PA. Some of her research has focused on how food preferences may be developed in the womb or during very early life. Select publications *Mennella JA, Jagnow CJ, Beauchamp GK. Prenatal and post-natal flavor learning by human infants. Pediatrics 107: e88, 2001. *Mennella JA, Ventura AK, Beauchamp, GK. Differential growth patterns among healthy infants fed protein hydrolysate or cow-milk formulas. Pediatrics 127(1):110-8, 2011. . *Mennella JA, Lukasewycz LD, Castor S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alan Gelperin
Dr. Alan Gelperin is a scientist and biologist currently at Princeton University. He is an emeritus faculty member at Monell Chemical Senses Center. He specializes in electronic olfaction and computational neuroscience. He received his bachelor's degree in biology from Carleton College in 1962 and went on to get a Ph.D. from University of Pennsylvania. He is most notable for his efforts in creating robots with electronic noses which can localize odors, and for the invention of a supermarket A supermarket is a self-service Retail#Types of outlets, shop offering a wide variety of food, Drink, beverages and Household goods, household products, organized into sections. This kind of store is larger and has a wider selection than earli ... fruit and vegetable scanner that does not use barcodes but instead scans by scent. References External linksDr. Gelperin's publications [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pamela Dalton
Pamela Dalton is a cognitive psychologist. She has a Ph.D. in experimental psychology and a Masters in Public Health. Dalton is frequently quoted by the popular press as an authority on environmental odors. She has done extensive research in the fields of sick building syndrome and multiple chemical sensitivity. In the past she has worked with the United States Department of Defense on nonlethal weapons development, or the enhancement of bad odors as weapons. She currently works at the Monell Chemical Senses Center. NIH Toolbox Dalton was a contributor to the NIH Toolbox for the Assessment of Neurological and Behavioral Function, as a member of the NIH Toolbox steering committee and the Olfaction team, developing the NIH Toolbox Odor Identification Test. The contract for the NIH Toolbox The NIH Toolbox®, for the assessment of neurological and behavioral function, is a multidimensional set of brief royalty-free measures that researchers and clinicians can use to assess cognitive, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paul Breslin
Paul Breslin is a geneticist and biologist. He is most notable for his work in taste perception and oral irritation, in humans as well as in ''Drosophila melanogaster'', the common fruit fly. He is a member of the faculty at the Monell Chemical Senses Center and acts as director of the Science Apprenticeship Program. He is a professor in the Department of Nutritional Sciences at Rutgers, the State University of New Jersey. Breslin and two colleaguesdiscovered that Oleocanthal Oleocanthal is a phenylethanoid, or a type of natural phenolic compound found in extra-virgin olive oil. It appears to be responsible for the burning sensation that occurs in the back of the throat when consuming such oil. Oleocanthal is a tyroso ..., a compound found in extra-virgin olive oil kills a variety of human cancer cells without harming healthy cells. References Living people Year of birth missing (living people) Place of birth missing (living people) Nationality missing Rutgers Uni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gary Beauchamp
Dr. Gary K. Beauchamp was the director and president of the Monell Chemical Senses Center from August 1990 to September 2014. Dr. Beauchamp graduated from Carleton College in 1965 with a bachelor's degree in biology. He received his Ph.D. in biopsychology in 1971 from The Pritzker School of Medicine of the University of Chicago. He joined the newly established Monell Center as a postdoctoral fellow in 1971, was appointed to the faculty in 1973, and attained the rank of Member in 1981. Dr. Beauchamp maintains an active research program at Monell, exploring varied topics related to taste, olfaction, and chemesthesis. Trained as a psychobiologist, his research has contributed to advancements in the fields of developmental psychology, physiological psychology, and perception; he also has made important contributions to the fields of genetics, developmental biology, immunobiology, ethology, and molecular biology. Considered one of the world's leading experts on chemosensory science ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexander Bachmanov
Dr. Alexander Bachmanov studied veterinary medicine at the Saint Petersburg Veterinary Institute, Russia (1977-1982), received his Ph.D. in biological sciences from the Pavlov Institute of Physiology in Saint Petersburg, Russia in 1990. He completed postdoctoral fellowships at the Physiological Laboratory at Cambridge University in 1993 and at the Monell Chemical Senses Center, Philadelphia, Pennsylvania, in the United States from 1994 to 1997. He later joined Monnell's faculty. Career and research His research at the Monell Chemical Senses Center focused on the genetics of taste, ingestive behavior, alcohol intake, metabolism and obesity. Bachmanov and his collaborators pioneered using the positional cloning approach to identify genes influencing behavior. Their identification of the mouse saccharin preference (Sac') genetic locus as a gene encoding the TAS1R3 taste receptor was the first successful positional cloning of a behavioral quantitative trait locus (QTL). They h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Placebo
A placebo ( ) is a substance or treatment which is designed to have no therapeutic value. Common placebos include inert tablets (like sugar pills), inert injections (like Saline (medicine), saline), sham surgery, and other procedures. In general, placebos can affect how patients perceive their condition and encourage the body's chemical processes for relieving pain and a few other symptoms, but have no impact on the disease itself. Improvements that patients experience after being treated with a placebo can also be due to unrelated factors, such as regression to the mean (a statistical effect where an unusually high or low measurement is likely to be followed by a less extreme one). The use of placebos in clinical medicine raises ethical concerns, especially if they are disguised as an active treatment, as this introduces dishonesty into the doctor–patient relationship and bypasses informed consent. While it was once assumed that this deception was necessary for placebos to have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oleocanthal
Oleocanthal is a phenylethanoid, or a type of natural phenolic compound found in extra-virgin olive oil. It appears to be responsible for the burning sensation that occurs in the back of the throat when consuming such oil. Oleocanthal is a tyrosol ester and its chemical structure is related to oleuropein, also found in olive oil. Potential biological effects Anti-inflammatory Oleocanthal has been found to have anti-inflammatory and antioxidant properties ''in vitro''. Similar to classical non-steroidal anti-inflammatory drugs, it is a non-selective inhibitor of cyclooxygenase (COX). 50 g (more than three and a half tablespoons) of a typical extra virgin olive oil per day contains an amount of oleocanthal with similar ''in vitro'' anti-inflammatory effect as 1/10 of the adult ibuprofen dose. It is therefore suggested that long-term consumption of small quantities may be responsible in part for the low incidence of heart disease and Alzheimer's disease associated with a Mediter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TAS1R3
Taste receptor type 1 member 3 is a protein that in humans is encoded by the ''TAS1R3'' gene. The ''TAS1R3'' gene encodes the human homolog of mouse Sac taste receptor, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharin, and other sweeteners. Structure The protein encoded by the ''TAS1R3'' gene is a G protein-coupled receptor with seven trans-membrane domains and is a component of the heterodimeric amino acid taste receptor TAS1R1+3 and sweet taste receptor TAS1R2+3. This receptor is formed as a protein dimer with either TAS1R1 or TAS1R2. Experiments have also shown that a homo-dimer of TAS1R3 is also sensitive to natural sugar substances. This has been hypothesized as the mechanism by which sugar substitutes do not have the same taste qualities as natural sugars. Ligands The G protein-coupled receptors for sweet and umami taste are formed by dimers of the TAS1R proteins. The TAS1R1+3 ta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
