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Min Chiu Li
Min Chiu Li (; 1919–1980) was a Chinese-American oncologist and cancer researcher. Li was the first scientist to use chemotherapy to cure widely metastatic, malignant cancer. Early life and education Born in China, Li studied at Mukden Medical College in present-day Shenyang. Li came to the United States in 1947 for medical training at the University of Southern California, but was unable to return to his home country due to the Chinese Revolution. Li served as a resident at Chicago's Presbyterian Hospital (now Rush University Medical Center) and from 1953 to 1955 worked as a Damon Runyon Fellow at Memorial Hospital (now Memorial Sloan Kettering Cancer Center) in New York City. In 1955, Li accepted a position as an assistant obstetrician in the laboratory of Roy Hertz at the National Cancer Institute (NCI). Li took the job primarily to avoid being drafted into the US military during the Korean War, but became obsessed with finding a cancer cure after watching patients d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mukden
Shenyang (, ; ; Mandarin pronunciation: ), formerly known as Fengtian () or by its Manchu name Mukden, is a major Chinese sub-provincial city and the provincial capital of Liaoning province. Located in central-north Liaoning, it is the province's most populous city, with a total population of 9,070,093 inhabitants as of the 2020 census. Among the resident population of the city, the male population is 4,521,021, accounting for 49.85%; the female population is 4,549,072, accounting for 50.15%. The sex ratio of the total population (with women as 100, the ratio of men to women) dropped from 102.10 in the sixth national census in 2010 to 99.38. Its built-up (or metro) area encompassing 8 Shenyang urban districts and the 4 Fushun urban districts, was home to 8,192,848 inhabitants in 2020. It is also the largest city in Northeast China by urban population, with 7.49 million people (2020 census). Shenyang is also the central city of one of the major megalopolises in China, the Gre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roy Hertz
Roy is a masculine given name and a family surname with varied origin. In Anglo-Norman England, the name derived from the Norman ''roy'', meaning "king", while its Old French cognate, ''rey'' or ''roy'' (modern ''roi''), likewise gave rise to Roy as a variant in the Francophone world. In India, Roy is a variant of the surname ''Rai'',. likewise meaning "king".. It also arose independently in Scotland, an anglicisation from the Scottish Gaelic nickname ''ruadh'', meaning "red". Given name * Roy Acuff (1903–1992), American country music singer and fiddler * Roy Andersen (born 1955), runner * Roy Andersen (South Africa) (born 1948), South African businessman and military officer * Roy Anderson (American football) (born 1980), American football coach * Sir Roy M. Anderson (born 1947), British scientific adviser * Roy Andersson (born 1943), Swedish film director * Roy Andersson (footballer) (born 1949), footballer from Sweden * Roy Chapman Andrews (1884–1960), American ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Chorionic Gonadotropin
Human chorionic gonadotropin (hCG) is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo (syncytiotrophoblast initially), which eventually forms the placenta after implantation. The presence of hCG is detected in some pregnancy tests (HCG pregnancy strip tests). Some cancerous tumors produce this hormone; therefore, elevated levels measured when the patient is not pregnant may lead to a cancer diagnosis and, if high enough, paraneoplastic syndromes, however, it is not known whether this production is a contributing cause, or an effect of carcinogenesis. The pituitary analog of hCG, known as luteinizing hormone (LH), is produced in the pituitary gland of males and females of all ages. Various endogenous forms of hCG exist. The measurement of these diverse forms is used in the diagnosis of pregnancy and a variety of disease states. Preparations of hCG from various sources have also been used therapeutically, by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. Risk factors for developing breast cancer include obesity, a lack of physical exercise, alcoholism, hormone replacement therapy during menopause, ionizing radiation, an early age at first menstruation, having children late in life or not at all, older age, having a prior history of breast cancer, and a family history of breast cancer. About 5–10% of cases are the result of a genetic predisposition inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jane C
Jane may refer to: * Jane (given name), a feminine given name * Jane (surname), related to the given name Film and television * ''Jane'' (1915 film), a silent comedy film directed by Frank Lloyd * ''Jane'' (2016 film), a South Korean drama film starring Lee Min-ji * ''Jane'' (2017 film), an American documentary film about Jane Goodall * ''Jane'' (2022 film), an American psychological thriller directed by Sabrina Jaglom * Jane (TV series), an 1980s British television series Music * ''Jane'' (album), an album by Jane McDonald * Jane (American band) * Jane (German band) * Jane, unaccompanied and original singer of "It's a Fine Day" in 1983 Songs * "Jane" (Barenaked Ladies song), 1994 * "Jane", a song by Ben Folds Five from their 1999 album ''The Unauthorized Biography of Reinhold Messner'' * "Jane" (Century song) * "Jane", a song by Elf Power * "Jane", a song by EPMD from '' Strictly Business'' * "Jane" (Jefferson Starship song), 1979 * "Jane", a song by the Loved Ones fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminopterin
Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities. Uses Discovered by Yellapragada Subbarow, the drug was first used by Sidney Farber in 1947 to induce remissions among children with leukemia. Aminopter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Receptor Antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of receptor proteins.Pharmacology Guide: In vitro pharmacology: concentration-response curves " '' GlaxoWellcome.'' Retrieved on December 6, 2007. They are sometimes called blockers; examples include alpha blockers, |
Leukemia
Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ''leukemia cells''. Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy. The exact cause of leukemia is unknown. A combination of genetic factors and environmental (non-inherited) factors are believed to play a role. Risk factors include smoking, ionizing radiation, petrochemicals (such as benzene), prior chemotherapy, and Down syndrome. People with a family history of leukemia are also at higher risk. There are four main types of leukemia— acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Folic Acid
Folate, also known as vitamin B9 and folacin, is one of the B vitamins. Manufactured folic acid, which is converted into folate by the body, is used as a dietary supplement and in food fortification as it is more stable during processing and storage. Folate is required for the body to make DNA and RNA and metabolise amino acids necessary for cell division. As humans cannot make folate, it is required in the diet, making it an essential nutrient. It occurs naturally in many foods. The recommended adult daily intake of folate in the U.S. is 400 micrograms from foods or dietary supplements. Folate in the form of folic acid is used to treat anemia caused by folate deficiency. Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in the baby. Low levels in early pregnancy are believed to be the cause of more than half of babies born with NTDs. More than 80 countries use either mandatory or voluntary fortification of c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sidney Farber
Sidney Farber (September 30, 1903 – March 30, 1973) was an American pediatric pathologist. He is regarded as the father of modern chemotherapy for his work using folic acid antagonists to combat leukemia, which led to the development of other chemotherapeutic agents against other malignancies. Farber was also active in cancer research advocacy and fundraising, most notably through his establishment of the Jimmy Fund, a foundation dedicated to pediatric research in childhood cancers. The Dana–Farber Cancer Institute is named after him. Early life He was born in Buffalo, New York, to Jewish parents Simon and Matilda (Goldstein) Farber. He was the third of 14 children. He was the younger brother of the noted philosopher and University of Buffalo professor Marvin Farber (1901–1980). Farber graduated from University at Buffalo, The State University of New York, or SUNY Buffalo, in 1923. Farber Hall, built in 1953 on the South Campus of SUNY Buffalo, is named for him. In the m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methotrexate
Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. It is used to treat cancer, autoimmune diseases, and ectopic pregnancies. Types of cancers it is used for include breast cancer, leukemia, lung cancer, lymphoma, gestational trophoblastic disease, and osteosarcoma. Types of autoimmune diseases it is used for include psoriasis, rheumatoid arthritis, and Crohn's disease. It can be given by mouth or by injection. Common side effects include nausea, feeling tired, fever, increased risk of infection, low white blood cell counts, and breakdown of the skin inside the mouth. Other side effects may include liver disease, lung disease, lymphoma, and severe skin rashes. People on long-term treatment should be regularly checked for side effects. It is not safe during breastfeeding. In those with kidney problems, lower doses may be needed. It acts by blocking the body's use of folic acid. Methotrexate was first made in 1947 and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antifolate
Antifolates are a class of antimetabolite medications that antagonise (that is, block) the actions of folic acid (vitamin B9). Folic acid's primary function in the body is as a cofactor to various methyltransferases involved in serine, methionine, thymidine and purine biosynthesis. Consequently, antifolates inhibit cell division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in microbial organisms such as bacteria, protozoa and fungi. The majority of antifolates work by inhibiting dihydrofolate reductase (DHFR). Comparison of available agents Mechanism Many are primarily DHFR inhibitors, but raltitrexed is an inhibitor of thymidylate synthase, and pemetrexed inhibits both and a third enzyme. Antifolates act specifically during DNA and RNA synthesis, and thus are cytotoxic during the S-phase of the cell cycle. Thus, they have a greater toxic effect on rapidly dividing cells (such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
