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Microgravity Bioprinting
Microgravity bioprinting is the utilization of 3D bioprinting techniques under microgravity conditions to fabricate highly complex, functional tissue and organ structures. The zero gravity environment circumvents some of the current limitations of bioprinting on Earth including magnetic field disruption and biostructure retention during the printing process. Microgravity bioprinting is one of the initial steps to advancing in space exploration and colonization while furthering the possibilities of regenerative medicine. General principle The main function microgravity bioprinting has over the other 3D bioprinting techniques is the utilization of a zero gravity environment. All other techniques of 3D bioprinting have been tested in space including extrusion-based printing, lithography-based printing, laser-based printing, droplet-based printing, magnetic field-based printing, and magnetic levitation-based printing. The optimal microgravity bioprinting technique is to utilize form ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microgravity Bioprinter
The term micro-g environment (also μg, often referred to by the term microgravity) is more or less synonymous with the terms ''weightlessness'' and ''zero-g'', but emphasising that g-forces are never exactly zero—just very small (on the International Space Station (ISS), for example, the small g-forces come from tidal effects, gravity from objects other than the Earth, such as astronauts, the spacecraft, and the Sun, air resistance, and astronaut movements that impart momentum to the space station). The symbol for microgravity, ''μg'', was used on the insignias of Space Shuttle flights STS-87 and STS-107, because these flights were devoted to microgravity research in low Earth orbit. The most commonly known microgravity environment can be found aboard the ISS which is located in low-earth orbit at an altitude of around 400 km, orbiting Earth approximately 15 times per day in what is considered free fall. The effects of free fall also enable the creation of short-du ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3D Bioprinting
Three dimensional (3D) bioprinting is the utilization of 3D printing–like techniques to combine cells, growth factors, and/or biomaterials to fabricate biomedical parts, often with the aim of imitating natural tissue characteristics. Generally, 3D bioprinting can utilize a layer-by-layer method to deposit materials known as Bio-ink, bio-inks to create tissue-like structures that are later used in various medical and tissue engineering fields. 3D bioprinting covers a broad range of bioprinting techniques and biomaterials. Currently, bioprinting can be used to print tissue and organ models to help research drugs and potential treatments. Nonetheless, translation of bioprinted living cellular constructs into clinical application is met with several issues due to the complexity and cell number needed to create functional organs. However, innovations span from bioprinting of extracellular matrix to mixing cells with Hydrogel, hydrogels deposited layer by layer to produce the desired tis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micro-g Environment
The term micro-g environment (also μg, often referred to by the term microgravity) is more or less synonymous with the terms ''weightlessness'' and ''zero-g'', but emphasising that g-forces are never exactly zero—just very small (on the International Space Station (ISS), for example, the small g-forces come from tidal effects, gravity from objects other than the Earth, such as astronauts, the spacecraft, and the Sun, air resistance, and astronaut movements that impart momentum to the space station). The symbol for microgravity, ''μg'', was used on the insignias of Space Shuttle flights STS-87 and STS-107, because these flights were devoted to microgravity research in low Earth orbit. The most commonly known microgravity environment can be found aboard the ISS which is located in low-earth orbit at an altitude of around 400 km, orbiting Earth approximately 15 times per day in what is considered free fall. The effects of free fall also enable the creation of short-du ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regenerative Medicine
Regenerative medicine deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ transplant rejection via immunological mismatch is circumvented. This approach could alleviate the problem of the shortage of organs available for donation. Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differenti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organ
Organ may refer to: Biology * Organ (biology), a part of an organism Musical instruments * Organ (music), a family of keyboard musical instruments characterized by sustained tone ** Electronic organ, an electronic keyboard instrument ** Hammond organ, an electro-mechanical keyboard instrument ** Pipe organ, a musical instrument that produces sound when pressurized air is driven through a series of pipes ** Street organ, a mobile, automatic mechanical pneumatic organ played by an organ grinder ** Theatre organ, a pipe organ originally designed specifically for imitation of an orchestra Films * ''Organ'' (film), a 1996 Japanese film about organ thieves * ''The Organ'' (film), a 1965 Slovak film Periodicals * Organ, any official periodical (i.e., magazine, newsletter, or similar publication) of an organization * ''Organ'' (magazine), a UK music magazine founded in 1986 * ''The Organ'' (magazine), a quarterly publication for organ enthusiasts, founded in 1921 * ''The Organ'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biofabrication
Biofabrication is a branch of biotechnology specialising in the research and development of biologically engineered processes for the automated production of biologically functional products through bioprinting or bioassembly and subsequent tissue maturation processes; as well as techniques such as directed assembly, which employs localised external stimuli guide the fabrification process; enzymatic assembly, which utilises selective biocatalysts to build macromolecular structures; and self-assembly, in which the biological material guides its own assembly according to its internal information. These processes may facilitate fabrication at the micro- and nanoscales. Biofabricated products are constructed and structurally organised with a range of biological materials including bioactive molecules, biomaterials, living cell The cell is the basic structural and functional unit of life forms. Every cell consists of a cytoplasm enclosed within a membrane, and contains many ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bio-ink
Bio-inks are materials used to produce engineered/artificial live tissue using 3D printing. These inks are mostly composed of the cells that are being used, but are often used in tandem with additional materials that envelope the cells. The combination of cells and usually biopolymer gels are defined as a bio-ink. They must meet certain characteristics, including such as rheological, mechanical, biofunctional and biocompatibility properties, among others. Using bio-inks provides a high reproducibility and precise control over the fabricated constructs in an automated manner. These inks are considered as one of the most advanced tools for tissue engineering and regenerative medicine (TERM). Like the thermoplastics that are often utilized in traditional 3D printing, bio-inks can be extruded through printing nozzles or needles into filaments that can maintain its shape fidelity after deposition. However, bio-inks are sensitive to the normal 3D printing processing conditions. Differ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
International Space Station
The International Space Station (ISS) is the largest modular space station currently in low Earth orbit. It is a multinational collaborative project involving five participating space agencies: NASA (United States), Roscosmos (Russia), JAXA (Japan), ESA (Europe), and CSA (Canada). The ownership and use of the space station is established by intergovernmental treaties and agreements. The station serves as a microgravity and space environment research laboratory in which scientific research is conducted in astrobiology, astronomy, meteorology, physics, and other fields. The ISS is suited for testing the spacecraft systems and equipment required for possible future long-duration missions to the Moon and Mars. The ISS programme evolved from the Space Station ''Freedom'', a 1984 American proposal to construct a permanently crewed Earth-orbiting station, and the contemporaneous Soviet/Russian '' Mir-2'' proposal from 1976 with similar aims. The ISS is the ninth space station to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Magnetic 3D Bioprinting
Magnetic 3D bioprinting is a methodology that employs biocompatible magnetic nanoparticles to print cells into 3D structures or 3D cell cultures. In this process, cells are tagged with magnetic nanoparticles (''nanoshuttle'') that are used to render them magnetic. Once magnetic, these cells can be rapidly printed into specific 3D patterns using external magnetic forces that mimic tissue structure and function. General principle There are several advantages to using magnetic 3D bioprinting over other 3D printing modalities such as extrusion, photolithography, and stereolithography. This includes the rapid bioprinting process (15 min – 1 h) compared to the days-long processes of others; the endogenous synthesis of extracellular matrix (ECM) without the need of an artificial protein substrate; and fine spatial control. Using this system, 3D cell culture models can be rapidly printed, from simple spheroids and rings to more complex organotypic models, such as the lung, aortic valv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nanoparticle
A nanoparticle or ultrafine particle is usually defined as a particle of matter that is between 1 and 100 nanometres (nm) in diameter. The term is sometimes used for larger particles, up to 500 nm, or fibers and tubes that are less than 100 nm in only two directions. At the lowest range, metal particles smaller than 1 nm are usually called atom clusters instead. Nanoparticles are usually distinguished from microparticles (1-1000 µm), "fine particles" (sized between 100 and 2500 nm), and "coarse particles" (ranging from 2500 to 10,000 nm), because their smaller size drives very different physical or chemical properties, like colloidal properties and ultrafast optical effects or electric properties. Being more subject to the brownian motion, they usually do not sediment, like colloidal particles that conversely are usually understood to range from 1 to 1000 nm. Being much smaller than the wavelengths of visible light (400-700 nm), nano ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
STS-134 International Space Station After Undocking
STS-134 (ISS assembly sequence, ISS assembly flight ULF6) was the penultimate mission of NASA's Space Shuttle program and the 25th and last spaceflight of . This flight delivered the Alpha Magnetic Spectrometer and an ExPRESS Logistics Carrier to the International Space Station. Mark Kelly (astronaut), Mark Kelly served as the mission commander. STS-134 was expected to be the final Space Shuttle mission if STS-135 did not receive funding from United States Congress, Congress. However, in February 2011, NASA stated that STS-135 would fly "regardless" of the funding situation.STS-134 Mission Status Spaceflight Now. STS-135, flown by Space Shuttle Atlantis, ''Atlantis'', took advantage of the processing for STS-3xx#STS-335, STS-335, the Launch on Need mission that would have been necessary if the STS-134 crew became st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tissue Engineering
Tissue engineering is a biomedical engineering discipline that uses a combination of Cell (biology), cells, engineering, Materials science, materials methods, and suitable biochemistry, biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biology, biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds. While it was once categorized as a sub-field of biomaterials, having grown in scope and importance it can be considered as a field of its own. While most definitions of tissue engineering cover a broad range of applications, in practice the term is closely associated with applications that repair or replace portions of or whole tissues (i.e. bone, Autologous chondrocyte implantation, cartilage, blood vessels, Urinary bladder, bladder, skin, muscle etc.). Often, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
