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Michael G. Rossmann
Michael G. Rossmann (30 July 1930 – 14 May 2019) was a German-American physicist, microbiologist, and Hanley Distinguished Professor of Biological Sciences at Purdue University who led a team of researchers to be the first to map the structure of a human common cold virus to an atomic level. He also discovered the Rossmann fold protein motif. His most well recognised contribution to structural biology is the development of a phasing technique named molecular replacement, which has led to about three quarters of depositions in the Protein Data Bank. Education Born in Frankfurt, Germany, Rossmann studied physics and mathematics at the University of London, where he received BSc and MSc degrees. He moved to Glasgow in 1953 where he taught physics in the technical college and received his Ph.D. in chemical crystallography in 1956. He attributes his initial interest in crystallography to Kathleen Lonsdale, whom he heard speak as a schoolboy. Rossmann began his career as a crystall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
West Lafayette, Indiana
West Lafayette () is a city in Wabash Township, Tippecanoe County, Indiana, United States, about northwest of the state capital of Indianapolis and southeast of Chicago. West Lafayette is directly across the Wabash River from its sister city, Lafayette. As of the 2020 census, its population was 44,595. It is the most densely populated city in Indiana and is home to Purdue University. History Augustus Wylie laid out a town in 1836 in the Wabash River floodplain south of the present Levee. Due to regular flooding of the site, Wylie's town was never built. The present city was formed in 1888 by the merger of the adjacent suburban towns of Chauncey, Oakwood, and Kingston, located on a bluff across the Wabash River from Lafayette, Indiana. The three towns had been small suburban villages which were directly adjacent to one another. Kingston was laid out in 1855 by Jesse B. Lutz. Chauncey was platted in 1860 by the Chauncey family of Philadelphia, wealthy land speculators. Ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Data Bank
The Protein Data Bank (PDB) is a database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids. The data, typically obtained by X-ray crystallography, NMR spectroscopy, or, increasingly, cryo-electron microscopy, and submitted by biologists and biochemists from around the world, are freely accessible on the Internet via the websites of its member organisations (PDBe, PDBj, RCSB, and BMRB). The PDB is overseen by an organization called the Worldwide Protein Data Bank, wwPDB. The PDB is a key in areas of structural biology, such as structural genomics. Most major scientific journals and some funding agencies now require scientists to submit their structure data to the PDB. Many other databases use protein structures deposited in the PDB. For example, SCOP and CATH classify protein structures, while PDBsum provides a graphic overview of PDB entries using information from other sources, such as Gene ontology. History Two force ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dogfish Sharks
Squalidae, more commonly known as dogfish, dog sharks, or spiny dogfish, are one of several families of sharks categorized under Squaliformes, making it the second largest order of sharks, numbering 119 species across 7 families. Having earned their name after a group of fishermen reportedly observed the species chasing down smaller fish in dog-like packs, dogfish have slender, streamlined bodies, usually more compact in comparison to other species, and a pointed snout. Dogfish likewise have two dorsal fins, each with smooth spines, but no anal fin, and their skin is generally rough to the touch. As the species reaches adulthood, males usually measure a maximum of 39 inches (990 mm), while females typically measure 49 inches (1,200 mm) long. The species therefore exhibits female-dominant sexual dimorphism. Dogfish sharks have slate-gray or gray-brown skin with white dots that becomes paler (almost white) around the belly region. These sharks are characterized by teeth i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indiana University
Indiana University (IU) is a system of public universities in the U.S. state of Indiana. Campuses Indiana University has two core campuses, five regional campuses, and two regional centers under the administration of IUPUI. *Indiana University Bloomington (IU Bloomington) is the flagship campus of Indiana University. The Bloomington campus is home to numerous premier Indiana University schools, including the College of Arts and Sciences, the Jacobs School of Music, an extension of the Indiana University School of Medicine, the School of Informatics, Computing, and Engineering, which includes the former School of Library and Information Science (now Department of Library and Information Science), School of Optometry, the O'Neil School of Public and Environmental Affairs, the Maurer School of Law, the School of Education, and the Kelley School of Business. *Indiana University–Purdue University Indianapolis (IUPUI), a partnership between Indiana University and Purdue Universi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cornell University
Cornell University is a private statutory land-grant research university based in Ithaca, New York. It is a member of the Ivy League. Founded in 1865 by Ezra Cornell and Andrew Dickson White, Cornell was founded with the intention to teach and make contributions in all fields of knowledge—from the classics to the sciences, and from the theoretical to the applied. These ideals, unconventional for the time, are captured in Cornell's founding principle, a popular 1868 quotation from founder Ezra Cornell: "I would found an institution where any person can find instruction in any study." Cornell is ranked among the top global universities. The university is organized into seven undergraduate colleges and seven graduate divisions at its main Ithaca campus, with each college and division defining its specific admission standards and academic programs in near autonomy. The university also administers three satellite campuses, two in New York City and one in Education City, Qatar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laboratory Of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical research laboratory at the forefront of scientific discovery, dedicated to improving the understanding of key biological processes at atomic, molecular and cellular levels using multidisciplinary methods, with a focus on using this knowledge to address key issues in human health. A new replacement building constructed close by to the original site on the Cambridge Biomedical Campus was opened by Her Majesty the Queen in May 2013. The road outside the new building is named Francis Crick Avenue after the 1962 joint Nobel Prize winner and LMB alumnus, who co-discovered the helical structure of DNA in 1953. History Origins: 1947-61 Max Perutz, following undergraduate training in organic chemistry, left Austria in 1936 and came to the Universi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Research Council (UK)
The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom. It is part of United Kingdom Research and Innovation (UKRI), which came into operation 1 April 2018, and brings together the UK's seven research councils, Innovate UK and Research England. UK Research and Innovation is answerable to, although politically independent from, the Department for Business, Energy and Industrial Strategy. The MRC focuses on high-impact research and has provided the financial support and scientific expertise behind a number of medical breakthroughs, including the development of penicillin and the discovery of the structure of DNA. Research funded by the MRC has produced 32 Nobel Prize winners to date. History The MRC was founded as the Medical Research Committee and Advisory Council in 1913, with its prime role being the distribution of medical research funds under the terms of the National Insurance Act 1911. This was a consequen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemoglobin
Hemoglobin (haemoglobin BrE) (from the Greek word αἷμα, ''haîma'' 'blood' + Latin ''globus'' 'ball, sphere' + ''-in'') (), abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein present in red blood cells (erythrocytes) of almost all vertebrates (the exception being the fish family Channichthyidae) as well as the tissues of some invertebrates. Hemoglobin in blood carries oxygen from the respiratory organs (''e.g.'' lungs or gills) to the rest of the body (''i.e.'' tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power functions of an organism in the process called metabolism. A healthy individual human has 12to 20grams of hemoglobin in every 100mL of blood. In mammals, the chromoprotein makes up about 96% of the red blood cells' dry content (by weight), and around 35% of the total content (including water). Hemoglobin has an oxygen-binding capacity of 1.34mL O2 per gram, which increases the total blood oxygen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Cambridge
, mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Scholars of the University of Cambridge , type = Public research university , endowment = £7.121 billion (including colleges) , budget = £2.308 billion (excluding colleges) , chancellor = The Lord Sainsbury of Turville , vice_chancellor = Anthony Freeling , students = 24,450 (2020) , undergrad = 12,850 (2020) , postgrad = 11,600 (2020) , city = Cambridge , country = England , campus_type = , sporting_affiliations = The Sporting Blue , colours = Cambridge Blue , website = , logo = University of Cambridge logo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Terpenoid
The terpenoids, also known as isoprenoids, are a class of naturally occurring organic chemicals derived from the 5-carbon compound isoprene and its derivatives called terpenes, diterpenes, etc. While sometimes used interchangeably with "terpenes", terpenoids contain additional functional groups, usually containing oxygen. When combined with the hydrocarbon terpenes, terpenoids comprise about 80,000 compounds. They are the largest class of plant secondary metabolites, representing about 60% of known natural products. Many terpenoids have substantial pharmacological bioactivity and are therefore of interest to medicinal chemists. Plant terpenoids are used for their aromatic qualities and play a role in traditional herbal remedies. Terpenoids contribute to the scent of eucalyptus, the flavors of cinnamon, cloves, and ginger, the yellow color in sunflowers, and the red color in tomatoes. Well-known terpenoids include citral, menthol, camphor, salvinorin A in the plant '' Salvia di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Minnesota
The University of Minnesota, formally the University of Minnesota, Twin Cities, (UMN Twin Cities, the U of M, or Minnesota) is a public university, public Land-grant university, land-grant research university in the Minneapolis–Saint Paul, Twin Cities of Minneapolis and Saint Paul, Minnesota, United States. The Twin Cities campus comprises locations in Minneapolis and Falcon Heights, Minnesota, Falcon Heights, a suburb of St. Paul, approximately apart. The Twin Cities campus is the oldest and largest in the University of Minnesota system and has the List of United States university campuses by enrollment, ninth-largest main campus student body in the United States, with 52,376 students at the start of the 2021–22 academic year. It is the Flagship#Colleges and universities in the United States, flagship institution of the University of Minnesota System, and is organized into 19 colleges, schools, and other major academic units. The Minnesota Territorial Legislature drafted a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kathleen Lonsdale
Dame Kathleen Lonsdale ( Yardley; 28 January 1903 – 1 April 1971) was an Irish-born British pacifist, prison reformer and crystallographer. She proved, in 1929, that the benzene ring is flat by using X-ray diffraction methods to elucidate the structure of hexamethylbenzene. She was the first to use Fourier spectral methods while solving the structure of hexachlorobenzene in 1931. During her career she attained several firsts for female scientists, including being one of the first two women elected a Fellow of the Royal Society (FRS) in 1945 (along with Marjory Stephenson), first woman tenured professor at University College London, first woman president of the International Union of Crystallography, and first woman president of the British Association for the Advancement of Science. Early life and education She was born Kathleen Yardley at Newbridge, County Kildare, Ireland, the tenth child of Harry Yardley, the town postmaster, and Jessie Cameron. Kathleen's family was no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
