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Melissa Little
Melissa Helen Little is an Australian scientist and academic, currently Theme Director of Cell Biology, heading up the Kidney Regeneration laboratory at the Murdoch Children's Research Institute. She is also a Professor in the Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, and Program Leader of Stem Cells Australia. In January 2022, she became CEO of the Novo Nordisk Foundation Center for Stem Cell Medicine reNEW, an international stem cell research center based at University of Copenhagen, and a collaboration between the University of Copenhagen, Denmark, Murdoch Children’s Research Institute, Australia, and Leiden University Medical Center, The Netherlands. She is internationally recognized both for her work on the systems biology of kidney development and also for her pioneering studies into potential regenerative therapies in the kidney. In 2015, Professor Melissa Little and her team at Murdoch Children’s Research Institute produced the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brisbane
Brisbane ( ) is the capital and most populous city of the states and territories of Australia, Australian state of Queensland, and the list of cities in Australia by population, third-most populous city in Australia and Oceania, with a population of approximately 2.6 million. Brisbane lies at the centre of the South East Queensland metropolitan region, which encompasses a population of around 3.8 million. The Brisbane central business district is situated within a peninsula of the Brisbane River about from its mouth at Moreton Bay, a bay of the Coral Sea. Brisbane is located in the hilly floodplain of the Brisbane River Valley between Moreton Bay and the Taylor Range, Taylor and D'Aguilar Range, D'Aguilar mountain ranges. It sprawls across several local government in Australia, local government areas, most centrally the City of Brisbane, Australia's most populous local government area. The demonym of Brisbane is ''Brisbanite''. The Traditional Owners of the Brisbane a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicholas Hastie
Professor Nicholas Dixon Hastie (born 1947) CBE, FRS, FRSE is a British geneticist, and former Director of the MRC Human Genetics Unit at the University of Edinburgh. Education Hastie was educated at the University of Liverpool and the University of Cambridge. Awards and honours Hastie was elected a Fellow of the Royal Society in 2002. His nomination reads Hastie was also a member of the Faculty of 1000 F1000 (formerly "Faculty of 1000") is an open research publisher for scientists, scholars, and clinical researchers. F1000 offers a different research evaluation service from standard academic journals by offering peer-review after, rather than .... References {{DEFAULTSORT:Hastie, Nicholas British geneticists Commanders of the Order of the British Empire Fellows of the Royal Society Fellows of the Royal Society of Edinburgh Living people 1947 births Alumni of the University of Liverpool ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Murdoch Childrens Research Institute
The Murdoch Children's Research Institute (MCRI) is an Australian paediatric medical research institute located in Melbourne, Victoria, affiliated with the Royal Children's Hospital and the University of Melbourne. The institute has six research themes: cellular biology, clinical sciences, genetics, infection and immunity, population health, and data science. History The institute was established in 1986 by Professor David Danks, after media magnate Rupert Murdoch and his family donated 5 million to the Birth Defects Research Institute at the Royal Children's Hospital in Melbourne in 1984. The institute was later renamed the Murdoch Institute for Research into Birth Defects, and Rupert's mother, Dame Elisabeth Murdoch became its patron. In 2000, the Murdoch Institute merged with the medical research institute of the Royal Children's Hospital to become the Murdoch Children's Research Institute. See also *Health in Australia References External links * Murdoch C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Development (journal)
''Development'' is a bi-weekly peer-reviewed scientific journal in the field of developmental biology that covers cellular and molecular mechanisms of animal and plant development. It is published by The Company of Biologists. ''Development'' is partnered with Publons, is part of the Review Commons initiative and has two-way integration with bioRxiv. In 2009, the BioMedical & Life Sciences Division of the Special Libraries Association included ''Development'' in their list of top 100 journals in Biology and Medicine over the last 100 years. Brief history Originally called ''Journal of Embryology and Experimental Morphology'' () and established in 1953, the journal provided a periodical that would be primarily devoted to morphogenesis. In 1987, the journal was renamed ''Development''. The journal's full archive from 1953 is available online. ''Development'' is now a hybrid journal and publishes 24 issues a year. Content over 6 months old is free to read. Scope and content ''De ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simon McKeon
Simon Vincent McKeon (born 19 December 1955) is an Australian lawyer, businessman, and administrator. He has been chancellor of Monash University, and non-executive director of Rio Tinto, Spotless Group, and National Australia Bank. He is retained by Macquarie Bank Melbourne as a consultant and is a fellow of the Australian Institute of Company Directors. On 25 January 2011 he was named the 2011 Australian of the Year. Business After completing a Bachelor of Commerce in 1976 and Bachelor of Laws in 1978, both at the University of Melbourne, Simon McKeon practised law in Sydney with Blake Dawson Waldron before taking up a post with the Macquarie Bank, where he became the Executive Chairman (Melbourne Office). He was Founding President of the statutory dispute resolution body for Australian public company takeovers, the Australian Takeovers Panel from 1999– 2010. He was also the Chairman of software specialist MYOB LTD 2006–2009. McKeon was chairman of CSIRO from June ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Robin Batterham
Robin John Batterham AO FREng FAA FTSE (born 3 April 1941) is an Australian scientist specialising in chemical engineering. He was the Chief Scientist of Australia from 1999 to 2006. Born in the Melbourne suburb of Brighton, Batterham graduated from the University of Melbourne in 1965 with a degree in chemical engineering, and received a PhD from the same institution in 1969. He received a scholarship from the Commonwealth Scientific and Industrial Research Organisation (CSIRO) to undertake postgraduate studies at the central research laboratories of ICI in the United Kingdom.Dr Robin Batterham . Batterham returned to Australia in 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Health And Medical Research Council
The National Health and Medical Research Council (NHMRC) is the main statutory authority of the Australian Government responsible for medical research. It was the eighth largest research funding body in the world in 2016, and NHMRC-funded research is globally recognised for its high quality. Around 45% of all Australian medical research from 200812 was funded by the federal government, through the NHMRC. As an independent arm of the Department of Health, the NHMRC funds high quality health and medical research, builds research capability in Australia, support the translation of health and medical research into better health outcomes, and promote the ethics and integrity in research. Non-health research is funded by the Australian Research Council. Activities The National Health and Medical Research Council Act 1992' provides for NHMRC to pursue activities designed to: * raise the standard of individual and public health throughout Australia * foster the development of consi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA-Seq
RNA-Seq (named as an abbreviation of RNA sequencing) is a sequencing technique which uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment, analyzing the continuously changing cellular transcriptome. Specifically, RNA-Seq facilitates the ability to look at alternative gene spliced transcripts, post-transcriptional modifications, gene fusion, mutations/SNPs and changes in gene expression over time, or differences in gene expression in different groups or treatments. In addition to mRNA transcripts, RNA-Seq can look at different populations of RNA to include total RNA, small RNA, such as miRNA, tRNA, and ribosomal profiling. RNA-Seq can also be used to determine exon/intron boundaries and verify or amend previously annotated 5' and 3' gene boundaries. Recent advances in RNA-Seq include single cell sequencing, in situ sequencing of fixed tissue, and native RNA molecule sequencing with single-molecule real-time ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Loop Of Henle
In the kidney, the loop of Henle () (or Henle's loop, Henle loop, nephron loop or its Latin language, Latin counterpart ''ansa nephroni'') is the portion of a nephron that leads from the proximal convoluted tubule to the distal convoluted tubule. Named after its discoverer, the Germany, German anatomist Friedrich Gustav Jakob Henle, the loop of Henle's main function is to create a molecular diffusion, concentration gradient in the renal medulla, medulla of the kidney. By means of a countercurrent multiplier system, which uses electrolyte pumps, the loop of Henle creates an area of high urea concentration deep in the medulla, near the papillary duct in the collecting duct system. Water present in the filtrate in the papillary duct flows through aquaporin channels out of the duct, moving passively down its concentration gradient. This process reabsorbs water and creates a concentrated urine for excretion. Structure The loop of Henle can be divided into four parts: *Thin descending l ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nephron
The nephron is the minute or microscopic structural and functional unit of the kidney. It is composed of a renal corpuscle and a renal tubule. The renal corpuscle consists of a tuft of capillaries called a glomerulus and a cup-shaped structure called Bowman's capsule. The renal tubule extends from the capsule. The capsule and tubule are connected and are composed of epithelial cells with a lumen. A healthy adult has 1 to 1.5 million nephrons in each kidney. Blood is filtered as it passes through three layers: the endothelial cells of the capillary wall, its basement membrane, and between the foot processes of the podocytes of the lining of the capsule. The tubule has adjacent peritubular capillaries that run between the descending and ascending portions of the tubule. As the fluid from the capsule flows down into the tubule, it is processed by the epithelial cells lining the tubule: water is reabsorbed and substances are exchanged (some are added, others are removed); first with t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Podocyte
Podocytes are cells in Bowman's capsule in the kidneys that wrap around capillaries of the glomerulus. Podocytes make up the epithelial lining of Bowman's capsule, the third layer through which filtration of blood takes place. Bowman's capsule filters the blood, retaining large molecules such as proteins while smaller molecules such as water, salts, and sugars are filtered as the first step in the formation of urine. Although various viscera have epithelial layers, the name visceral epithelial cells usually refers specifically to podocytes, which are specialized epithelial cells that reside in the visceral layer of the capsule. One type of specialized epithelial cell is podocalyxin. The podocytes have long foot processes called ''pedicels'', for which the cells are named (''podo-'' + '' -cyte''). The pedicels wrap around the capillaries and leave slits between them. Blood is filtered through these slits, each known as a filtration slit, slit diaphragm, or slit pore. Several pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collecting Duct System
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis. The collecting duct system is the last part of nephron and participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone). There are several components of the collecting duct system, including the connecting tubules, cortical collecting ducts, and medullary collecting ducts. Structure Segments The segments of the system are as follows: Connecting tubule With respect to the renal corpuscle, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is the most proximal part of the collecting duct system. It is adjacent to the distal convoluted tubule, the most distal segment of the renal tubule. Connecting tubules from several adjacent nephrons merge to form cortical collecting tubules, and the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
