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Medicago Inc.
Medicago Inc. was a Canadian biotechnology company focused on the discovery, development, and commercialization of virus-like particles using plants as bioreactors to produce proteins, candidate vaccines, and medications. By using live plant leaves as hosts in the discovery and manufacturing process, the Medicago "''Proficia''" technology intended to create a rapid, high-yield system for its product candidates. Privately owned by a subsidiary of Mitsubishi Tanabe Pharma, Medicago and its product development programs were terminated by Mitsubishi in February 2023. The main clinical targets for Medicago product candidates were antiviral vaccines and antibody therapeutics. The company's name was derived from the Latin word for alfalfa, which was the first plant the company used to develop its technologies. Medicago technologies evolved from research at the Laval University and Agriculture and Agri-Food Canada in the 1990s. History A research partnership was formed between Laval ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medicago Logo
''Medicago'' is a genus of flowering plants, commonly known as medick or burclover, in the legume family (Fabaceae). It contains at least 87 species and is distributed mainly around the Mediterranean basin. The best-known member of the genus is alfalfa (''M. sativa''), an important forage crop, and the genus name is based on the Latin name for that plant, , from el, μηδική (πόα) Median (grass). Most members of the genus are low, creeping herbs, resembling clover, but with burs (hence the common name). However, alfalfa grows to a height of 1 meter, and tree medick (''M. arborea'') is a shrub. Members of the genus are known to produce bioactive compounds such as medicarpin (a flavonoid) and medicagenic acid (a triterpenoid saponin). Chromosome numbers in ''Medicago'' range from 2''n'' = 14 to 48. The species ''Medicago truncatula'' is a model legume due to its relatively small stature, small genome (450–500 Mbp), short generation time (about 3 months), and ability to r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agriculture And Agri-Food Canada
Agriculture and Agri-Food Canada (AAFC; sometimes Ag-Canada; french: Agriculture et Agroalimentaire Canada)''Agriculture and Agri-Food Canada'' is the applied title under the Federal Identity Program; the legal title is Department of Agriculture and Agri-Food (). is the department of the Government of Canada responsible for the federal regulation of agriculture, including policies governing the production, processing, and marketing of all farm, food, and agri-based products. Agriculture in Canada is a shared jurisdiction and the department works with the provinces and territories in the development and delivery of policies and programs. The minister of agriculture and agri-food (currently Marie-Claude Bibeau) is responsible for the department to Parliament. While the minister is head of the department, and provides policy/political direction, the day-to-day operations of the department are managed by the deputy minister (currently Chris Forbes), who is a public servant. His ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicotiana Benthamiana Leaf
''Nicotiana'' () is a genus of herbaceous plants and shrubs in the family Solanaceae, that is indigenous to the Americas, Australia, Southwestern Africa and the South Pacific. Various ''Nicotiana'' species, commonly referred to as tobacco plants, are cultivated as ornamental garden plants. '' N. tabacum'' is grown worldwide for the cultivation of tobacco leaves used for manufacturing and producing tobacco products, including cigars, cigarillos, cigarettes, chewing tobacco, dipping tobacco, snuff, and snus. Taxonomy Species The 79 accepted species include: * ''Nicotiana acuminata'' (Graham) Hook. – manyflower tobaccoKnapp et al. (2004) Nomenclatural changes and a new sectional classification in Nicotiana (Solanaceae) Taxon. 53(1):73-82. * ''Nicotiana africana'' Merxm. * ''Nicotiana alata'' Link & Otto – jasmine tobacco, sweet tobacco, winged tobacco, Persian tobacco, ''tanbaku'' (in Persian) * ''Nicotiana attenuata'' Torrey ex S. Watson – coyote tobacco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Canada
Health Canada (HC; french: Santé Canada, SC)Health Canada is the applied title under the Federal Identity Program; the legal title is Department of Health (). is the Structure of the Canadian federal government#Departments, with subsidiary units, department of the Government of Canada responsible for national health policy. The department itself is also responsible for numerous federal health-related agencies, including the Canadian Food Inspection Agency (CFIA) and the Public Health Agency of Canada (PHAC), among others. These organizations help to ensure compliance with federal law in a variety of Healthcare in Canada, healthcare, Agriculture in Canada, agricultural, and Pharmaceutics, pharmaceutical activities. This responsibility also involves extensive collaboration with various other federal- and provincial-level organizations in order to ensure the safety of food, health, and Medication, pharmaceutical products—including the regulation of health research and pharmaceutic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Adverse Effect
An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. The term complication is similar to adverse effect, but the latter is typically used in pharmacological contexts, or when the negative effect is expected or common. If the negative effect results from an unsuitable or incorrect dosage or procedure, this is called a medical error and not an adverse effect. Adverse effects are sometimes referred to as "iatrogenic" because they are generated by a physician/treatment. Some adverse effects occur only when starting, increasing or discontinuing a treatment. Adverse effects can also be caused by placebo treatments (in which case the adverse effects are referred to as nocebo effects). Using a drug or other medical intervention which is contraindicated may increase the risk of adverse effects. Adverse effects may c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CoVLP
CoVLP (brand name ''Covifenz'') was a COVID-19 vaccine developed by Medicago in Canada and GlaxoSmithKline (GSK). The product and Medicago, Inc. were owned by Mitsubishi who terminated the company and program in February 2023 due to high international market competition for COVID-19 vaccines. It is a coronavirus virus-like particle vaccine grown in the Australian weed, ''Nicotiana benthamiana''. The Medicago method to manufacture CoVLP was a "molecular farming" technology regarded as rapid, low-cost, and safe. It was proposed specifically for production of COVID-19 vaccines. In February 2022, Health Canada authorized use of CoVLP for preventing COVID-19 infection in adults 18 to 64 years old. The authorization stated there was an efficacy rate of 71% after two vaccinations against symptoms of COVID-19 disease and 100% efficacy against severe COVID-19 infections. Efficacy On 7 December 2021, Medicago-GSK announced a preliminary analysis showing an overall efficacy of 71%, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coronavirus Disease 2019
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease quickly spread worldwide, resulting in the COVID-19 pandemic. The symptoms of COVID‑19 are variable but often include fever, cough, headache, fatigue, breathing difficulties, loss of smell, and loss of taste. Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms. Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging), and 5% develop critical symptoms (respiratory failure, shock, or multiorgan dysfunction). Older people are at a higher risk of developing seve ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicotiana Benthamiana
''Nicotiana benthamiana'', colloquially known as benth or benthi, is a species of ''Nicotiana'' indigenous to Australia. It is a close relative of tobacco. A synonym for this species is ''Nicotiana suaveolens'' var. ''cordifolia'', a description given by George Bentham in ''Flora Australiensis'' in 1868. This was transferred to ''Nicotiana benthamiana'' by Karel Domin in ''Bibliotheca Botanica'' (1929), honoring the original author in the specific epithet. History The plant was used by people of Australia as a stimulant, containing nicotine and other alkaloids, before the introduction of commercial tobacco ('' N. tabacum'' and '' N. rustica''). Indigenous names for it include ''tjuntiwari'' and ''muntju''. It was first collected on the north coast of Australia by Benjamin Bynoe on a voyage of in 1837. Description The herbaceous plant is found amongst rocks on hills and cliffs throughout the northern regions of Australia. Variable in height and habit, the species may be er ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seasonal Influenza
Flu season is an annually recurring time period characterized by the prevalence of an outbreak of influenza (flu). The season occurs during the cold half of the year in each hemisphere. It takes approximately two days to show symptoms. Influenza activity can sometimes be predicted and even tracked geographically. While the beginning of major flu activity in each season varies by location, in any specific location these minor epidemics usually take about three weeks to reach its pinnacle, and another three weeks to significantly diminish. Annually, about 3 to 5 million cases of severe illness and 290,000 to 650,000 deaths from seasonal flu occur worldwide. Cause Three virus families, Influenza virus A, B, and C are the main infective agents that cause influenza. During periods of cooler temperature, influenza cases increase roughly tenfold or more. Despite the higher incidence of manifestations of the flu during the season, the viruses are actually transmitted throughou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phases Of Clinical Research
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays. Summary Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years. If the drug successfully passes through Phases I, II, and III, it will usually be approved by the national regulatory authority for use in the general population. Phase IV trials are 'post-marketing' or 'surveillance' studies conducted to monitor safety over sever ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitsubishi Tanabe Pharma Corporation
Mitsubishi Tanabe Pharma Corporation is a Japanese pharmaceuticals company from Osaka, a subsidiary of Mitsubishi Chemical Holdings Corporation. was formed in 2001 from the merger of Mitsubishi-Tokyo Pharmaceuticals and Welfide Corporation. On October 1, 2007 Tanabe Seiyaku Co., Ltd. merged with Mitsubishi Pharma to form Mitsubishi Tanabe Pharma. Originally founded in 1678, Mitsubishi Tanabe considers itself as one of the oldest pharmaceutical companies in the world. Mitsubishi Tanabe Pharma is a member of the Mitsubishi UFJ Financial Group (MUFJ) keiretsu. Products Mitsubishi-Tanabe Pharmaceuticals developed the first BET inhibitor molecules. In August 2014, the company announced three-year research collaboration agreement with AstraZeneca on diabetic nephropathy, to replace dialysis or kidney transplantation. An intravenous treatment of Mitsubishi Tanabe is Radicava (edaravone) which has the goal to slow the decline of physical function in patients with amyotrophic lateral ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Philip Morris International
Philip Morris International Inc. (PMI) is an American Multinational corporation, multinational tobacco company, with products sold in over 180 countries. The most recognized and best selling product of the company is Marlboro. Philip Morris International is often referred to as one of the companies comprising Big Tobacco. Until a Corporate spin-off, spin-off in March 2008, Philip Morris International was an operating company of Altria. Altria explained the spin-off, arguing PMI would have more "freedom," i.e. leeway outside the responsibilities and standards of American corporate ownership in terms of potential litigation and legislative restrictions to "pursue sales growth in emerging markets", while Altria focuses on the American domestic market. The shareholders in Altria at the time were given shares in PMI, which was listed on the London Stock Exchange and other markets. The company's legal seat is in New York City, but it does not operate in the United States of America ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
