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Maxygen
Maxygen Inc. was a biopharmaceutical company focused on developing improved versions of protein drugs using DNA shuffling and other protein modification technologies. The company was headquartered in Redwood City, CA. It dissolved in 2013. The Maxygen legacy was revived in 2018 with a focus on Directed Evolution of Proteins using Molecular Breeding. Maxygen LLC is currently headquartered in Sunnyvale, CA. Clinical Programs Maxygen Inc's clinical programs included a novel G-CSF for the treatment of chemotherapy-induced neutropenia, which entered clinical trials in 2006. Maxygen also had a preclinical program, MAXY-4, to develop a novel CTLA4-Ig therapeutic for the treatment of rheumatoid arthritis and other autoimmune diseases. Technologies Maxygen Inc. was established to commercially exploit its proprietary recombination-based technologies for creating genetic diversity, known as its Molecular Breeding directed evolution platform. These technologies allow the generation of m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Profound Pharma
Profound Pharma A/S was a Danish company that develops 2nd generation biopharmaceuticals. History Created in Denmark in 1999 by Christian Karsten Hansen and Jan Møller Mikkelsen, formerly of Novo Nordisk, the company was funded by venture capital and a loan from Vækstfonden. After rapidly growing to employ 50 scientists, and filing large numbers of patent applications, the company was acquired by Maxygen in 2000, for $60 million in stock. From its acquisition by Maxygen until 2008, the company continued as a subsidiary of Maxygen forming the cornerstone of its biopharmaceutical business, and contributing to Maxygen´s molecular breeding technology. With NeuroSearch, Genmab and Zealand Pharma, Profound Pharma was among the early members of the Medicon Valley biotech cluster. Its initial directors were Dr. Claus Bræstrup, Prof. Thue Schwartz and Knud Aunstrup. Projects Profound Pharma developed improved versions of interferon beta, granulocyte colony-stimulating factor, TNF in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christian Karsten Hansen
Christian Karsten Hansen (born 18 August 1966) is a Danish biotechnology entrepreneur, investor and inventor, with work in new drugs, molecular biology and biochemistry. Personal background Originally from Copenhagen (Denmark), he spent his childhood in Antwerp, Belgium and Caracas, Venezuela before completing high school at Sorø Academy in 1984. Following graduation as MSc chemical engineering from the Technical University of Denmark in 1989, PhD work in molecular biology and biochemistry was conducted at the Pasteur Institute, France and the University of Salamanca, Spain. He also completed an MBA from the Edinburgh Business School, Scotland. Professional background Hansen held positions as senior scientist and director of intellectual property management at Novo Nordisk 1992–1999, and was a member of Enzyme Research Management. He co-founded one of the early Danish biotechnology companies, Profound Pharma, in 1999, with Jan Møller Mikkelsen, and remained co-CEO thereof ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Codexis
Codexis, Inc. is a protein engineering company that develops enzymes for pharmaceutical, food and medical applications. History Codexis is based in Redwood City, CA and was incorporated in 2002. It went public in April 2010 on NASDAQ, and in October, acquired Maxygen's MolecularBreeding technology portfolio. Pharmaceutical Codexis won the Presidential Green Chemistry Challenge Award from the U.S. Environmental Protection Agency (EPA) in 2006 for its work on a building block of Lipitor. It then won a second time in 2010 for its work with Merck & Co. on the active ingredient in Januvia. Nutrition In 2017, the company entered a partnership with Tate & Lyle to provide research and development for the production of new ingredients. That same year, Codexis announced a collaboration with Nestle to provide enzymes for metabolic disorders. Biotherapeutics In 2017, Codexis developed a recombinant phenylalanine ammonia-lyase (PAL) enzyme, to act as a substitute phenylalanine h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alejandro Zaffaroni
Alejandro Zaffaroni (February 27, 1923 – March 1, 2014) was a Uruguayan serial entrepreneur who was responsible for founding several biotechnology companies in Silicon Valley. Products that he was involved in developing include the birth control pill, the nicotine patch, corticosteroids, and the DNA microarray. Education Zaffaroni was born on February 27, 1923 in Montevideo. Zaffaroni was of Italian descent, as his grandfather migrated from Italy to Uruguay at the age of 16. Both of Zaffaroni's parents passed away early in his life; his mother when he was 12 and his father when he was 18. His father was in the banking business. Zaffaroni received his Bachelor of Science degree from the University of the Republic in 1945, and his Ph.D. in biochemistry from the University of Rochester in 1949. Career Zaffaroni joined Syntex, then a small chemical company in Mexico, as a biochemist in 1951. He participated in turning Syntex into a major multinational pharmaceutical company, movi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Public Company
A public company is a company whose ownership is organized via shares of stock which are intended to be freely traded on a stock exchange or in over-the-counter markets. A public (publicly traded) company can be listed on a stock exchange (listed company), which facilitates the trade of shares, or not (unlisted public company). In some jurisdictions, public companies over a certain size must be listed on an exchange. In most cases, public companies are ''private'' enterprises in the ''private'' sector, and "public" emphasizes their reporting and trading on the public markets. Public companies are formed within the legal systems of particular states, and therefore have associations and formal designations which are distinct and separate in the polity in which they reside. In the United States, for example, a public company is usually a type of corporation (though a corporation need not be a public company), in the United Kingdom it is usually a public limited company (plc), i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Santa Clara, California
Santa Clara (; Spanish for " Saint Clare") is a city in Santa Clara County, California. The city's population was 127,647 at the 2020 census, making it the eighth-most populous city in the Bay Area. Located in the southern Bay Area, the city was founded by the Spanish in 1777 with the establishment of Mission Santa Clara de Asís under the leadership of Junípero Serra. Santa Clara is located in the center of Silicon Valley and is home to the headquarters of companies such as Intel, Advanced Micro Devices, and Nvidia. It is also home to Santa Clara University, the oldest university in California, and Levi's Stadium, the home of the National Football League's San Francisco 49ers, and Cedar Fair's California's Great America Park. Santa Clara is bordered by San Jose on all sides, except for Sunnyvale and Cupertino to the west. History The Tamien tribe of the Ohlone nation of Indigenous Californians have inhabited the area for thousands of years. Spanish period The fir ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recombinant Factor VIIa
Recombinant factor VIIa also known as eptacog alfa (INN), and sold under the brand name NovoSeven among others, is a form of blood factor VII that has been manufactured via recombinant technology. It is administered intravenously (IV). Medical uses NovoSeven is approved for use in the United States and is indicated for the treatment of bleeding episodes and for the prevention of bleeding in surgical interventions or invasive procedures in patients with acquired hemophilia. NovoSeven RT is approved in the United States and is indicated for the treatment of bleeding episodes and peri-operative management in adults and children with hemophilia A or B with inhibitors, congenital Factor VII (FVII) deficiency, and Glanzmann's thrombasthenia with refractoriness to platelet transfusions, with or without antibodies to platelets and for the treatment of bleeding episodes and peri-operative management in adults with acquired hemophilia. Sevenfact oagulation factor VIIa (recombinant)-jnc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amgen
Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical Corporation, company headquartered in Thousand Oaks, California. One of the world's largest independent biotechnology companies, Amgen was established in Thousand Oaks, California, in 1980.Baker, Pam (2002). ''Thousand Oaks Westlake Village: A Contemporary Portrait''. Community Communications, Inc. Page 37. . Amgen's Thousand Oaks staff in 2017 numbered 5,125 (7.5% of total city employment) and included hundreds of scientists, making Amgen the largest employer in Ventura County, California, Ventura County. Focused on molecular biology and biochemistry, its goal is to provide a healthcare business based on recombinant DNA technology. In 2018, the company's largest selling product lines were Neulasta, an immunostimulator used to prevent infections in patients undergoing cancer chemotherapy and Enbrel, a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DuPont
DuPont de Nemours, Inc., commonly shortened to DuPont, is an American multinational chemical company first formed in 1802 by French-American chemist and industrialist Éleuthère Irénée du Pont de Nemours. The company played a major role in the development of Delaware and first arose as a major supplier of gunpowder. DuPont developed many polymers such as Vespel, neoprene, nylon, Corian, Teflon, Mylar, Kapton, Kevlar, Zemdrain, M5 fiber, Nomex, Tyvek, Sorona, Corfam and Lycra in the 20th century, and its scientists developed many chemicals, most notably Freon (chlorofluorocarbons), for the refrigerant industry. It also developed synthetic pigments and paints including ChromaFlair. In 2015, DuPont and the Dow Chemical Company agreed to a reorganization plan in which the two companies would merge and split into three. As a merged entity, DuPont simultaneously acquired Dow and renamed itself to DowDuPont on August 31, 2017, and after 18 months spin off the merged entity' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subtilisin
Subtilisin is a protease (a protein-digesting enzyme) initially obtained from ''Bacillus subtilis''. Subtilisins belong to subtilases, a group of serine proteases that – like all serine proteases – initiate the nucleophilic attack on the peptide (amide) bond through a serine residue at the active site. Subtilisins typically have molecular weights 27kDa. They can be obtained from certain types of soil bacteria, for example, ''Bacillus amyloliquefaciens'' from which they are secreted in large amounts. Nomenclature Subtilisin is also commercially known as ''Alcalase®'', ''Endocut-02L'', ''ALK-enzyme'', ''bacillopeptidase'', ''Bacillus subtilis alkaline proteinase bioprase'', ''bioprase AL'', ''colistinase'', ''genenase I'', ''Esperase®'', ''maxatase'', ''protease XXVII'', ''thermoase'', ''superase'', ''subtilisin DY'', ''subtilopeptidase'', ''SP 266'', ''Savinase®'', ''kazusase'', ''protease VIII'', ''protin A 3L'', ''Savinase®'', ''orientase 10B'', ''protease S.'' It ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genencor International
Genencor is a biotechnology company based in Palo Alto, CA and a subsidiary of IFF. Genencor is a producer of Industrial enzymes and low-priced bulk protein. The name Genencor originates with Genencor, Inc., the original joint venture between Genentech and Corning Incorporated, which was founded in 1982. It is considered to have pioneered the field of industrial biotechnology, as distinct from traditional applications of biotechnology to health care and agriculture. In 2005 Genencor was acquired by Danisco. In 2008 Genencor entered a joint venture with DuPont, called DuPont Danisco Cellulosic Ethanol LLC, to develop and commercialize low cost technology for the production of cellulosic ethanol. In 2008, Genencor and Goodyear announced they were working to develop BioIsoprene. In 2011, Dupont acquired Danisco for $6.3 billion. In 2021, portions of Dupont including the Genencor division were acquired by International Flavors & Fragrances. Awards Genencor achieved the follo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diversa
Verenium Corporation was a San Diego, California-based industrial biotechnology company founded in 2007 as the result of a merger between Diversa (San Diego) and Celunol (Cambridge, MA). The company specialized in research and development for the production of high performance enzymes used in industrial applications, including biofuel generation, hydraulic fracturing. Verenium was acquired by BASF corporation in 2013. The company's tailored enzymes are environmentally friendly, making products and processes greener and more cost-effective for industries including the global food and fuel markets. Using proprietary and patented genomic technologies, BASF extracts microbial DNA directly from collected samples to avoid the slow and often impossible task of growing microbes in the laboratory. BASF then mines its collection of microbial genes, numbering in the billions, using high-throughput screening technologies designed to identify unique enzymes as product candidates. As required, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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