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Maximum Age
Maximum life span (or, for humans, maximum reported age at death) is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death. The term can also denote an estimate of the maximum amount of time that a member of a given species could survive between birth and death, provided circumstances that are optimal to that member's longevity. Most living species have an upper limit on the number of times somatic cells not expressing telomerase can divide. This is called the Hayflick limit, although this number of cell divisions does not strictly control lifespan. Definition In animal studies, maximum span is often taken to be the mean life span of the most long-lived 10% of a given cohort. By another definition, however, maximum life span corresponds to the age at which the oldest known member of a species or experimental group has died. Calculation of the maximum life span in the latter sense depends upon the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humans
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, and language. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states. Social interactions between humans have established a wide variety of values, social norms, and rituals, which bolster human society. Its intelligence and its desire to understand and influence the environment and to explain and manipulate phenomena have motivated humanity's development of science, philosophy, mythology, religion, and other fields of study. Although some scientists equate the term ''humans'' with all members of the genus ''Homo'', in common usage, it generally refers to ''Homo sapiens'', the only extant member. Anatomically ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suicide
Suicide is the act of intentionally causing one's own death. Mental disorders (including depression, bipolar disorder, schizophrenia, personality disorders, anxiety disorders), physical disorders (such as chronic fatigue syndrome), and substance abuse (including alcoholism and the use of and withdrawal from benzodiazepines) are risk factors. Some suicides are impulsive acts due to stress (such as from financial or academic difficulties), relationship problems (such as breakups or divorces), or harassment and bullying. Those who have previously attempted suicide are at a higher risk for future attempts. Effective suicide prevention efforts include limiting access to methods of suicide such as firearms, drugs, and poisons; treating mental disorders and substance abuse; careful media reporting about suicide; and improving economic conditions. Although crisis hotlines are common resources, their effectiveness has not been well studied. The most commonly adopted metho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stretched Exponential Function
The stretched exponential function f_\beta (t) = e^ is obtained by inserting a fractional power law into the exponential function. In most applications, it is meaningful only for arguments between 0 and +∞. With , the usual exponential function is recovered. With a ''stretching exponent'' ''β'' between 0 and 1, the graph of log ''f'' versus ''t'' is characteristically ''stretched'', hence the name of the function. The compressed exponential function (with ) has less practical importance, with the notable exception of , which gives the normal distribution. In mathematics, the stretched exponential is also known as the complementary cumulative Weibull distribution. The stretched exponential is also the characteristic function, basically the Fourier transform, of the Lévy symmetric alpha-stable distribution. In physics, the stretched exponential function is often used as a phenomenological description of relaxation in disordered systems. It was first introduced by Rudo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biodemography Of Human Longevity
Biodemography is a multidisciplinary approach, integrating biological knowledge (studies on human biology and animal models) with demographic research on human longevity and survival. Biodemographic studies are important for understanding the driving forces of the current longevity revolution (dramatic increase in human life expectancy), forecasting the future of human longevity, and identification of new strategies for further increase in healthy and productive life span. Theory Biodemographic studies have found a remarkable similarity in survival dynamics between humans and laboratory animals. Specifically, three general biodemographic laws of survival are found: # Gompertz–Makeham law of mortality # Compensation law of mortality # Late-life mortality deceleration (now disputed *) The Gompertz–Makeham law states that death rate is a sum of age-independent component ( Makeham term) and age-dependent component (Gompertz function), which increases exponentially with age. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York City
New York, often called New York City or NYC, is the List of United States cities by population, most populous city in the United States. With a 2020 population of 8,804,190 distributed over , New York City is also the List of United States cities by population density, most densely populated major city in the United States, and is more than twice as populous as second-place Los Angeles. New York City lies at the southern tip of New York (state), New York State, and constitutes the geographical and demographic center of both the Northeast megalopolis and the New York metropolitan area, the largest metropolitan area in the world by urban area, urban landmass. With over 20.1 million people in its metropolitan statistical area and 23.5 million in its combined statistical area as of 2020, New York is one of the world's most populous Megacity, megacities, and over 58 million people live within of the city. New York City is a global city, global Culture of New ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caloric Restriction Mimetic
Calorie restriction mimetics (CRM), also known as energy restriction mimetics, are a hypothetical class of dietary supplements or drug candidates that would, in principle, mimic the substantial anti-aging effects that calorie restriction (CR) has on many laboratory animals and humans. CR is defined as a reduction in calorie intake of 20% (mild CR) to 50% (severe CR) without incurring malnutrition or a reduction in essential nutrients. An effective CRM would alter the key metabolic pathways involved in the effects of CR itself, leading to preserved youthful health and longer lifespan without the need to reduce food intake. The term was coined by Lane, Ingram, Roth of the National Institute on Aging in a seminal 1998 paper in the ''Journal of Anti-Aging Medicine'', the forerunner of ''Rejuvenation Research''. A number of genes and pathways have been shown to be involved the actions of CR in model organisms and these represent attractive targets for drug discovery and for developing CRM ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Senescence
Senescence () or biological aging is the gradual deterioration of functional characteristics in living organisms. The word ''senescence'' can refer to either cellular senescence or to senescence of the whole organism. Organismal senescence involves an increase in death rates and/or a decrease in fecundity with increasing age, at least in the latter part of an organism's life cycle. Senescence is the inevitable fate of almost all multicellular organisms with germ-soma separation, but it can be delayed. The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats, and the existence of species having negligible senescence and potentially immortal organisms such as '' Hydra'', have motivated research into delaying senescence and thus age-related diseases. Rare human mutations can cause accelerated aging diseases. Environmental factors may affect aging – for example, overexposure to ultraviolet radiation accelerates skin aging. Different parts of the body ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mortality Rate
Mortality rate, or death rate, is a measure of the number of deaths (in general, or due to a specific cause) in a particular population, scaled to the size of that population, per unit of time. Mortality rate is typically expressed in units of deaths per 1,000 individuals per year; thus, a mortality rate of 9.5 (out of 1,000) in a population of 1,000 would mean 9.5 deaths per year in that entire population, or 0.95% out of the total. It is distinct from "morbidity", which is either the prevalence or incidence of a disease, and also from the incidence rate (the number of newly appearing cases of the disease per unit of time). An important specific mortality rate measure is the crude death rate, which looks at mortality from all causes in a given time interval for a given population. , for instance, the CIA estimates that the crude death rate globally will be 7.7 deaths per 1,000 people in a population per year. In a generic form, mortality rates can be seen as calculated using (d/ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
France
France (), officially the French Republic ( ), is a country primarily located in Western Europe. It also comprises of Overseas France, overseas regions and territories in the Americas and the Atlantic Ocean, Atlantic, Pacific Ocean, Pacific and Indian Oceans. Its Metropolitan France, metropolitan area extends from the Rhine to the Atlantic Ocean and from the Mediterranean Sea to the English Channel and the North Sea; overseas territories include French Guiana in South America, Saint Pierre and Miquelon in the North Atlantic, the French West Indies, and many islands in Oceania and the Indian Ocean. Due to its several coastal territories, France has the largest exclusive economic zone in the world. France borders Belgium, Luxembourg, Germany, Switzerland, Monaco, Italy, Andorra, and Spain in continental Europe, as well as the Kingdom of the Netherlands, Netherlands, Suriname, and Brazil in the Americas via its overseas territories in French Guiana and Saint Martin (island), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jeanne Calment
Jeanne Louise Calment (; 21 February 1875 – 4 August 1997) was a French supercentenarian and the oldest human whose age is documented, with a lifespan of 122 years and 164 days. Her longevity attracted media attention and medical studies of her health and lifestyle. She is the only person verified to have lived to the age of 120 and beyond. According to census records, Calment outlived both her daughter and grandson. In January 1988, she was widely reported to have been the oldest living person, and in 1995, at age 120, was declared the oldest person to have lived. Early life Calment was born on 21 February 1875 in Arles, Bouches-du-Rhône, Provence. Some of her close family members also had an above-average lifespan as her older brother, François (1865–1962), lived to the age of 97, her father, Nicolas (1837–1931), who was a shipbuilder, 93, and her mother, Marguerite Gilles (1838–1924), who was from a family of millers, 86. From the age of seven until her ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerontology Research Group
The Gerontology Research Group (GRG) based in Los Angeles, California, USA, is a global social science organization of researchers in various fields of gerontology, primarily concerned with verifying and recording supercentenarians status (people who are at least 110 years old) through its verified oldest people list. The group endeavors to further gerontology research with a goal of slowing and reversing aging. History The GRG was founded in 1990 by L. Stephen Coles and Stephen M. Kaye. The original chapter the LA-GRG, holds meetings each month though the organization has members worldwide who meet via online forums. The GRG verifies supercentenarians (people at least 110 years old or elder) by validating proof-of-age documents. People that have attained supercentenarian status, are required to supply the organization documents that prove the persons birth date, change of name (if applicable), and date of death (if applicable), along with another piece of official governm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guinness World Records
''Guinness World Records'', known from its inception in 1955 until 1999 as ''The Guinness Book of Records'' and in previous United States editions as ''The Guinness Book of World Records'', is a reference book published annually, listing world records both of human achievements and the extremes of the natural world. The brainchild of Sir Hugh Beaver, the book was co-founded by twin brothers Norris and Ross McWhirter in Fleet Street, London, in August 1955. The first edition topped the best-seller list in the United Kingdom by Christmas 1955. The following year the book was launched internationally, and as of the 2022 edition, it is now in its 67th year of publication, published in 100 countries and 23 languages, and maintains over 53,000 records in its database. The international franchise has extended beyond print to include television series and museums. The popularity of the franchise has resulted in ''Guinness World Records'' becoming the primary international authority ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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