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Martin J. Evans
Sir Martin John Evans (born 1 January 1941) is an English biologist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981. He is also known, along with Mario Capecchi and Oliver Smithies, for his work in the development of the knockout mouse and the related technology of gene targeting, a method of using embryonic stem cells to create specific gene modifications in mice.Stem cell architect is knighted BBC News : Wednesday, 31 December 2003 (subscription required) In 2007, the three shared the in reco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stroud
Stroud is a market town and civil parish in Gloucestershire, England. It is the main town in Stroud District. The town's population was 13,500 in 2021. Below the western escarpment of the Cotswold Hills, at the meeting point of the Five Valleys, the town is noted for its steep streets. The Cotswold Area of Outstanding Natural Beauty surrounds the town, and the Cotswold Way path passes by it to the west. It lies south of the city of Gloucester, south-southwest of Cheltenham, west-northwest of Cirencester and north-east of the city of Bristol. London is east-southeast of Stroud and the Welsh border at Whitebrook, Monmouthshire, is to the west. Not part of the town itself, the civil parishes of Rodborough and Cainscross form part of Stroud's urban area. Stroud acts as a centre for surrounding villages and market towns including Amberley, Bisley, Bussage, Chalford, Dursley, Eastcombe, Eastington, King's Stanley, Leonard Stanley, Minchinhampton, Nailsworth, Oakri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christ's College, Cambridge
Christ's College is a constituent college of the University of Cambridge. The college includes the Master, the Fellows of the College, and about 450 undergraduate and 170 graduate students. The college was founded by William Byngham in 1437 as God's House. In 1505, the college was granted a new royal charter, was given a substantial endowment by Lady Margaret Beaufort, and changed its name to Christ's College, becoming the twelfth of the Cambridge colleges to be founded in its current form. Alumni of the college include some of Cambridge University’s most famous members, including Charles Darwin and John Milton. Within Cambridge, Christ's has a reputation for high academic standards. It has averaged 1st place on the Tompkins Table from 1980 to 2006 and third place from 2006 to 2013, returning to first place in 2018, 2019 and 2022. Simon McDonald is the college's current Master. Robert Evans is the chaplain; he was ordained in the Church of England. History Christ's Colleg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Independent
''The Independent'' is a British online newspaper. It was established in 1986 as a national morning printed paper. Nicknamed the ''Indy'', it began as a broadsheet and changed to tabloid format in 2003. The last printed edition was published on Saturday 26 March 2016, leaving only the online edition. The newspaper was controlled by Tony O'Reilly's Irish Independent News & Media from 1997 until it was sold to the Russian oligarch and former KGB Officer Alexander Lebedev in 2010. In 2017, Sultan Muhammad Abuljadayel bought a 30% stake in it. The daily edition was named National Newspaper of the Year at the 2004 British Press Awards. The website and mobile app had a combined monthly reach of 19,826,000 in 2021. History 1986 to 1990 Launched in 1986, the first issue of ''The Independent'' was published on 7 October in broadsheet format.Dennis Griffiths (ed.) ''The Encyclopedia of the British Press, 1422–1992'', London & Basingstoke: Macmillan, 1992, p. 330 It was produc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BBC Radio 4
BBC Radio 4 is a British national radio station owned and operated by the BBC that replaced the BBC Home Service in 1967. It broadcasts a wide variety of spoken-word programmes, including news, drama, comedy, science and history from the BBC's headquarters at Broadcasting House, London. The station controller is Mohit Bakaya. Broadcasting throughout the United Kingdom, the Isle of Man and the Channel Islands on FM, LW and DAB, and on BBC Sounds, it can be received in the eastern counties of Ireland, northern France and Northern Europe. It is available on Freeview, Sky, and Virgin Media. Radio 4 currently reaches over 10 million listeners, making it the UK's second most-popular radio station after Radio 2. BBC Radio 4 broadcasts news programmes such as ''Today'' and ''The World at One'', heralded on air by the Greenwich Time Signal pips or the chimes of Big Ben. The pips are only accurate on FM, LW, and MW; there is a delay on digital radio of three to five seconds and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Medicine
''Nature Medicine'' is a monthly Peer review, peer-reviewed medical journal published by Nature Portfolio covering all aspects of medicine. It was established in 1995. The journal seeks to publish research papers that "demonstrate novel insight into disease processes, with direct evidence of the physiological relevance of the results". As with other ''Nature'' journals, there is no external editorial board, with editorial decisions being made by an in-house team, although peer review by external expert referees forms a part of the review process. The editor-in-chief is João Monteiro (editor), João Monteiro. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor of 87.241, ranking it 1st out of 296 journals in the category "Biochemistry & Molecular Biology". References External links * {{Portal bar, Medicine Publications established in 1995 Nature Research academic journals General medical journals Monthly journals English-language journa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oliver Smithies
Oliver Smithies (23 June 1925 – 10 January 2017) was a British-American geneticist and physical biochemist. He is known for introducing starch as a medium for gel electrophoresis in 1955, and for the discovery, simultaneously with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previously used, and the technique behind gene targeting and knockout mice. He received the Nobel Prize in Physiology or Medicine in 2007 for his genetics work. Early life and education Smithies was born in Halifax, West Yorkshire, England, to William Smithies and his wife Doris, née Sykes. His father sold life insurance policies and his mother taught English at Halifax Technical College. He had a twin brother and a younger sister. He attended a primary school in the nearby village of Copley and then went to Heath Grammar School in Halifax. He said that his love of science ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mario Capecchi
Mario Ramberg Capecchi (born 6 October 1937) is an Italian-born molecular geneticist and a co-awardee of the 2007 Nobel Prize in Physiology or Medicine for discovering a method to create mice in which a specific gene is turned off, known as knockout mice. He shared the prize with Martin Evans and Oliver Smithies. He is currently Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine. Life Mario Capecchi was born in Verona, Italy, as the only child of Luciano Capecchi and Lucy Ramberg, an Italian-born daughter of American-born Impressionist painter Lucy Dodd Ramberg and German archaeologist Walter Ramberg. His parents weren't married, and due to the chaos in Europe caused by World War II, the story of his early life is remarkable, but the details are unclear. In 1941 he and his mother were living near Bolzano, about 160 miles north of his father in Reggio Emilia when his mother was arrested and deported for pamphleteering and belonging ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Embryonic Stem Cell
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre- implantation embryo. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells. Isolating the inner cell mass (embryoblast) using immunosurgery results in destruction of the blastocyst, a process which raises ethical issues, including whether or not embryos at the pre-implantation stage have the same moral considerations as embryos in the post-implantation stage of development. Researchers are currently focusing heavily on the therapeutic potential of embryonic stem cells, with clinical use being the goal for many laboratories. Potential uses include the treatment of diabetes and heart disease. The cells are being studied to be used as clinical therapies, models of genetic disorders, and cellular/DNA repair. However, adverse effects in the research and clinical processes such as tumors and unw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Culture
Cell culture or tissue culture is the process by which cells are grown under controlled conditions, generally outside of their natural environment. The term "tissue culture" was coined by American pathologist Montrose Thomas Burrows. This technique is also called micropropagation. After the cells of interest have been isolated from living tissue, they can subsequently be maintained under carefully controlled conditions the need to be kept at body temperature (37 °C) in an incubator. These conditions vary for each cell type, but generally consist of a suitable vessel with a substrate or rich medium that supplies the essential nutrients (amino acids, carbohydrates, vitamins, minerals), growth factors, hormones, and gases ( CO2, O2), and regulates the physio-chemical environment (pH buffer, osmotic pressure, temperature). Most cells require a surface or an artificial substrate to form an adherent culture as a monolayer (one single-cell thick), whereas others can be grown ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matthew Kaufman
Matthew H. Kaufman (29 September 1942 – 11 August 2013) was a British biologist. He was Professor Emeritus at University of Edinburgh having been Professor of Anatomy there from 1985 to 2007. He taught anatomy and embryology for more than 30 years, initially at the University of Cambridge, when he was a Fellow of King's College, and more recently (from 1985 to 1997) in Edinburgh. Born in London into an Orthodox Jewish family, during his early years at the University of Edinburgh, he re-instituted a course for an intercalated degree (an honours science degree taken within a medical degree course) in anatomy, absent for many years in this subject. With this he brought a new life of exploration and research within the department of anatomy. In 1981 Kaufman and Martin Evans at the University of Cambridge in England and Gail R. Martin in America were the first to derive embryonic stem cells (ES cells) from mouse embryos. He obtained a PhD in 1984 from the University of Edinburgh p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Desert Island Discs
''Desert Island Discs'' is a radio programme broadcast on BBC Radio 4. It was first broadcast on the BBC Forces Programme on 29 January 1942. Each week a guest, called a " castaway" during the programme, is asked to choose eight recordings (usually, but not always, music), a book and a luxury item that they would take if they were to be cast away on a desert island, whilst discussing their life and the reasons for their choices. It was devised and originally presented by Roy Plomley. Since 2018 the programme has been presented by Lauren Laverne. More than 3,000 episodes have been recorded, with some guests having appeared more than once and some episodes featuring more than one guest. An example of a guest who falls into both categories is Bob Monkhouse, who appeared with his co-writer Denis Goodwin on 12 December 1955 and in his own right on 20 December 1998. When ''Desert Island Discs'' marked its 75th year in 2017, ''The Guardian'' called the show a radio classic. In Februar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
