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Marcel Bessis
Marcel Claude Bessis (15 November 1917 – 28 March 1994) was a French physician known for research on blood cells. Bessis was born in Tunis on 15 November 1917. He was educated at the Lycée Janson-de-Sailly in Paris, France. He developed an interest in microscopy in his teenage years and went on to study medicine at the University of Paris. During the Second World War, he served as a military physician and pioneered the technique of exchange transfusion to treat war injuries. He graduated with a medical degree in 1944. Later he studied exchange transfusion as a treatment for hemolytic disease of the newborn, uremia and acute leukemia. He was a frequent collaborator of Jean Bernard. Bessis used electron microscopy and microcinematography to study the structure and function of blood cells—particularly red blood cells, but also platelets and white blood cells, including the abnormal cells found in leukemia. He invented new instruments to aid his research and developed techniq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tunis
''Tounsi'' french: Tunisois , population_note = , population_urban = , population_metro = 2658816 , population_density_km2 = , timezone1 = CET , utc_offset1 = +01:00 , timezone1_DST = , utc_offset1_DST = , postal_code_type = Postal code , postal_code = 1xxx, 2xxx , area_code_type = Calling code , area_code = 71 , iso_code = TN-11, TN-12, TN-13 and TN-14 , blank_name_sec2 = geoTLD , blank_info_sec2 = .tn , website = , footnotes = Tunis ( ar, تونس ') is the capital and largest city of Tunisia. The greater metropolitan area of Tunis, often referred to as " Grand Tunis", has about 2,700,000 inhabitants. , it is the third-largest city in the Maghreb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Leukemia
Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original diagnosis of leukemia. In most cases, these can be classified according to the lineage, myeloid or lymphoid, of the malignant cells that grow uncontrolled, but some are mixed and for those such an assignment is not possible. Forms of acute leukemia include: * Acute myeloid leukemia ** Acute erythroid leukemia * Acute lymphoblastic leukemia ** T-cell acute lymphoblastic leukemia *** Adult T-cell leukemia/lymphoma *** (Precursor) T-lymphoblastic leukemia/lymphoma * ''Blast crisis'' of chronic myelogenous leukemia Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulat ... References {{Set index article Leukemia ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nouvelle Revue D'hématologie
Nouvelle is a French word, the feminine form of "new". It may refer to: ;Places * Nouvelle, Quebec, a municipality in Quebec, Canada * Nouvelle-Église, a commune in the Pas-de-Calais department, France * Port-la-Nouvelle, a commune in the Aude department, France ;Other * Nouvelle, the French name for a novella * Nouvelle AI, an approach to the artificial intelligence in the 1980s * Nouvelle Chanson, a musical genre which emerged in France in the 1990s * ''Battle of the Brave (Nouvelle-France)'', a 2004 historical romance film directed by Jean Beaudin * Nouvelle histoire, a French historiographic current from the 1970s * Nouvelle Planète, a Swiss non-profit organization * Nouvelle Star, a French television series based on the Pop Idol programme * Nouvelle Tendance, an art movement founded in Yugoslavia in 1961 * Nouvelle Vague, informal denomination of a movement of French filmmakers of the late 1950s and 1960s * ''La Nouvelle Tribune ''La Nouvelle Tribune'' is a weekly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Discocyte
A biconcave disc — also referred to as a discocyte — is a geometric shape resembling an oblate spheroid with two concavities on the top and on the bottom. Biconcave discs appear in the study of cell biology, where it is meta-stable, and involves the continuous adjustment of the asymmetric transbilayer lipid distribution, which is correlated with ATP ATP may refer to: Companies and organizations * Association of Tennis Professionals, men's professional tennis governing body * American Technical Publishers, employee-owned publishing company * ', a Danish pension * Armenia Tree Project, non ... depletion. __TOC__ Mathematical model A biconcave disc can be described mathematically by :z(r) = D \sqrt \left(a_0 + \frac + \frac \right) where is the height of the surface as a function of radius , is the diameter of the disc, and are coefficients describing the shape. The above model describes a smooth surface; actual cells can be much more irregular. Biology Erythr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Echinocyte
Echinocyte (from the Greek word ''echinos'', meaning 'hedgehog' or 'sea urchin'), in human biology and medicine, refers to a form of red blood cell that has an abnormal cell membrane characterized by many small, evenly spaced thorny projections.Mentzer WC. Spiculated cells (echinocytes and acanthocytes) and target cells. UpToDate (release: 20.12- C21.4/ref> A more common term for these cells is burr cells. Physiology Echinocytes are frequently confused with acanthocytes, but the mechanism of cell membrane alteration is different. Echinocytosis is a reversible condition of red blood cells that is often merely an artifact produced by EDTA, which is used as an anticoagulant in sampled blood. Echinocytes can be distinguished from acanthocytes by the shape of the projections, which are smaller and more numerous than in acanthocytes and are evenly spaced. Echinocytes also exhibit central pallor, or lightening of color in the center of the cell under Wright staining. Causes In addition t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stomatocyte
Hereditary stomatocytosis describes a number of inherited, mostly autosomal dominant human conditions which affect the red blood cell and create the appearance of a slit-like area of central pallor (stomatocyte) among erythrocytes on peripheral blood smear. The erythrocytes' cell membranes may abnormally 'leak' sodium and/or potassium ions, causing abnormalities in cell volume. Hereditary stomatocytosis should be distinguished from acquired causes of stomatocytosis, including dilantin toxicity and alcoholism, as well as artifact from the process of preparing peripheral blood smears. Signs and symptoms Stomatocytosis may present with signs and symptoms consistent with hemolytic anemia as a result of extravascular hemolysis and often intravascular hemolysis. These include fatigue and pallor, as well as signs of jaundice, splenomegaly and gallstone formation from prolonged hemolysis. Certain cases of hereditary stomatocytosis associated with genetic syndromes have additional sympto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maxwell Wintrobe
Maxwell Myer Wintrobe (October 27, 1901 – December 9, 1986) was an Austrian-born American physician who was a 20th-century authority in the medical field of hematology. His 1942 textbook on hematology, ''Clinical Hematology'', was the first dedicated work in the field and he contributed to the diagnostic approach of anemia and copper metabolism, amongst many other achievements. Biography Wintrobe was born in Austria (Fred 2007), contrary to previous historical records. His family name reflects the Jewish origin of his parents, Herman and Ethel, who emigrated from Austria with their son Max in 1906. Canadian census records show that the family arrived in Halifax, Nova Scotia in 1906, where Ethel's four brothers were living at the time. The family moved to Manitoba in 1912. Wintrobe attended the University of Manitoba from the early age of 15, where he graduated in 1921 and obtained his M.D. in 1926. He married Becky Zamphir, and moved to the United States, where he obtained a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbeam
A microbeam is a narrow beam of radiation, of micrometer or sub-micrometer dimensions. Together with integrated imaging techniques, microbeams allow precisely defined quantities of damage to be introduced at precisely defined locations. Thus, the microbeam is a tool for investigators to study intra- and inter-cellular mechanisms of damage signal transduction. A schematic of microbeam operation is shown on the right. Essentially, an automated imaging system locates user-specified targets, and these targets are sequentially irradiated, one by one, with a highly-focused radiation beam. Targets can be single cells, sub-cellular locations, or precise locations in 3D tissues. Key features of a microbeam are throughput, precision, and accuracy. While irradiating targeted regions, the system must guarantee that adjacent locations receive no energy deposition. History The first microbeam facilities were developed in the mid-90s. These facilities were a response to challenges in studying ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leukemia
Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ''leukemia cells''. Symptoms may include bleeding and bruising, bone pain, fatigue, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy. The exact cause of leukemia is unknown. A combination of genetic factors and environmental (non-inherited) factors are believed to play a role. Risk factors include smoking, ionizing radiation, petrochemicals (such as benzene), prior chemotherapy, and Down syndrome. People with a family history of leukemia are also at higher risk. There are four main types of leukemia— acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
White Blood Cell
White blood cells, also called leukocytes or leucocytes, are the cell (biology), cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system. All white blood cells have cell nucleus, nuclei, which distinguishes them from the other blood cells, the anucleated red blood cells (RBCs) and platelets. The different white blood cells are usually classified by cell division, cell lineage (myelocyte, myeloid cells or lymphocyte, lymphoid cells). White blood cells are part of the body's immune system. They help the body fight infection and other diseases. Types of white blood cells are granulocytes (neutrophils, eosinophils, and basophils), and agranulocytes (monocytes, and lymphocytes (T cells and B cells)). Myeloid cells ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Platelets
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot. Platelets have no cell nucleus; they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow or lung, which then enter the circulation. Platelets are found only in mammals, whereas in other vertebrates (e.g. birds, amphibians), thrombocytes circulate as intact mononuclear cells. One major function of platelets is to contribute to hemostasis: the process of stopping bleeding at the site of interrupted endothelium. They gather at the site and, unless the interruption is physically too large, they plug the hole. First, platelets attach to substances outside the interrupted endothelium: ''adhesion''. Second, they change shape, turn on receptors and secrete chemical messengers: ''activatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Red Blood Cell
Red blood cells (RBCs), also referred to as red cells, red blood corpuscles (in humans or other animals not having nucleus in red blood cells), haematids, erythroid cells or erythrocytes (from Greek ''erythros'' for "red" and ''kytos'' for "hollow vessel", with ''-cyte'' translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system. RBCs take up oxygen in the lungs, or in fish the gills, and release it into tissues while squeezing through the body's capillaries. The cytoplasm of a red blood cell is rich in hemoglobin, an iron-containing biomolecule that can bind oxygen and is responsible for the red color of the cells and the blood. Each human red blood cell contains approximately 270 million hemoglobin molecules. The cell membrane is composed of proteins and lipids, and this structure provides properties essential for physiolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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