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Mandy Sellars
Mandy Sellars (born 20 February 1975 in Lancashire, United Kingdom) is a British woman with a rare genetic mutation that has resulted in extraordinary growth in both of her legs. In 2006, some doctors diagnosed Sellars as having Proteus syndrome, a very rare condition thought to affect only 120 people worldwide, but more recent diagnoses have focused on a '' PIK3CA'' gene mutation. Some reports still describe her condition as a rare form of Proteus syndrome, but Sellars herself has disputed the diagnosis. Sellars's condition has been covered in several television programs, leading Sellars to jokingly describe herself as a "part-time TV star". Biography Sellars was born with abnormally large and misshapen legs and feet, which continued to grow at a disproportionate rate. In a November 2009 interview, she estimated that she weighed about 21 stone (294 lb or 133 kg): 6 stone (84 lb or 38 kg) for her upper body and the remainder in her legs and feet (210 lb o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lancashire
Lancashire ( , ; abbreviated Lancs) is the name of a historic county, ceremonial county, and non-metropolitan county in North West England. The boundaries of these three areas differ significantly. The non-metropolitan county of Lancashire was created by the Local Government Act 1972. It is administered by Lancashire County Council, based in Preston, and twelve district councils. Although Lancaster is still considered the county town, Preston is the administrative centre of the non-metropolitan county. The ceremonial county has the same boundaries except that it also includes Blackpool and Blackburn with Darwen, which are unitary authorities. The historic county of Lancashire is larger and includes the cities of Manchester and Liverpool as well as the Furness and Cartmel peninsulas, but excludes Bowland area of the West Riding of Yorkshire transferred to the non-metropolitan county in 1974 History Before the county During Roman times the area was part of the Bri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methicillin-resistant Staphylococcus Aureus
Methicillin-resistant ''Staphylococcus aureus'' (MRSA) is a group of Gram-positive bacteria that are genetically distinct from other strains of ''Staphylococcus aureus''. MRSA is responsible for several difficult-to-treat infections in humans. It caused more than 100,000 deaths attributable to antimicrobial resistance in 2019. MRSA is any strain of ''S. aureus'' that has developed (through natural selection) or acquired (through horizontal gene transfer) a multiple drug resistance to beta-lactam antibiotics. Beta-lactam (β-lactam) antibiotics are a broad-spectrum group that include some penams (penicillin derivatives such as methicillin and oxacillin) and cephems such as the cephalosporins. Strains unable to resist these antibiotics are classified as methicillin-susceptible ''S. aureus'', or MSSA. MRSA is common in hospitals, prisons, and nursing homes, where people with open wounds, invasive devices such as catheters, and weakened immune systems are at greater risk of healt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
English People With Disabilities
English usually refers to: * English language * English people English may also refer to: Peoples, culture, and language * ''English'', an adjective for something of, from, or related to England ** English national identity, an identity and common culture ** English language in England, a variant of the English language spoken in England * English languages (other) * English studies, the study of English language and literature * ''English'', an Amish term for non-Amish, regardless of ethnicity Individuals * English (surname), a list of notable people with the surname ''English'' * People with the given name ** English McConnell (1882–1928), Irish footballer ** English Fisher (1928–2011), American boxing coach ** English Gardner (b. 1992), American track and field sprinter Places United States * English, Indiana, a town * English, Kentucky, an unincorporated community * English, Brazoria County, Texas, an unincorporated community * Engli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rapamycin
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mechanistic target of rapamycin kinase (mTOR) inhibitor that inhibits activation of T cells and B cells by reducing their sensitivity to interleukin-2 (IL-2). It is produced by the bacterium '' Streptomyces hygroscopicus'' and was isolated for the first time in 1972, from samples of ''Streptomyces hygroscopicus'' found on Easter Island. The compound was originally named rapamycin after the native name of the island, Rapa Nui. Sirolimus was initially developed as an antifungal agent. However, this use was abandoned when it was discovered to have potent immu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Off-label Use
Off-label use is the use of pharmaceutical drugs for an unapproved indication (medicine), indication or in an unapproved age group, dose (biochemistry), dosage, or route of administration. Both prescription drugs and over-the-counter drugs (OTCs) can be used in off-label ways, although most studies of off-label use focus on prescription drugs. Off-label use is very common and generally legal unless it violates ethical guidelines or safety regulations. The ability to prescribe drugs for uses beyond the officially approved indications is commonly used to good effect by healthcare providers. For example, methotrexate is commonly used off-label because its immunomodulatory effects relieve various disorders. However, off-label use can entail health risks and differences in legal liability. Pharmaceutical marketing, Marketing of pharmaceuticals for off-label use is usually prohibited. Indications and labeling laws An ''Indication (medicine), indication'' is when a drug is medically ap ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
P110α
The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol = PIK3CA; HGNC ID, HGNC:8975), also called p110α protein, is a class I PI 3-kinase catalytic subunit. The human p110α protein is encoded by the ''PIK3CA'' gene. Its role was uncovered by molecular pathological epidemiology (MPE). Function Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositol 3-kinase (PI3K)) is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate phosphatidylinositols (PtdIns), PtdIns4P and PtdIns(4,5)P2. The involvement of p110α in human cancer has been hypothesized since 1995. Support for this hypothesis came from genetic and functional studies, including the discovery of common activating PIK3CA missense mutations in common human tumors. It has been found to be oncogenic and is implicated in cervi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kevin Carroll (prosthetist)
Kevin Carroll is an Irish prosthetist, researcher, educator, and author. He is the Vice-President of Prosthetics for Hanger Clinic, a prosthetics and orthotics provider in the United States. Kevin travels around the United States and the world providing care for patients with unique or challenging cases and for disabled athletes. He also presents scientific symposiums and educational programs. Carroll is one of the most renowned prosthetists in the world. He is an American Board Certified Prosthetist and has been named a Fellow of the American Academy of Orthotists and Prosthetists. He is a member of the International Society for Prosthetics and Orthotics (ISPO), the British Association of Prosthetics and Orthotics (BAPO) and the National Association of Professional Geriatric Care Managers. In 2009 Carroll was awarded the Distinguished Service Award by the United States Sports Academy because of his contributions to the advancement of prosthetics and his dedication to numerous di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Extraordinary People (2003 TV Series)
''Extraordinary People'' is a television documentary film, documentary series broadcast on Channel 5 (UK), Channel 5 in the United Kingdom. Each programme follows the lives of people with a rare disease, rare medical condition and/or unusual Ability (other), ability. People featured have or had rare illnesses such as rabies and eye cancer. Many of these people do activities previously thought impossible for people in their condition. The show began airing on 28 March 2003. List of people featured *Petero Byakatonda, a Crouzon syndrome patient *Ellie, Georgie, Holly, and Jessica Carles, the only identical twin, identical quadruplets in Britain *David Fitzpatrick, fugue state (amnesia) sufferer *Jeanna Giese, the first rabies survivor, who was administered the Milwaukee protocol after being bitten by an infected bat *Abby and Brittany Hensel, Dicephalic parapagus twins, dicephalic parapagus conjoined twins *Akrit Jaswal, who performed his first surgery at age seven *Dede ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Deep Vein Thrombosis
Deep vein thrombosis (DVT) is a type of venous thrombosis involving the formation of a blood clot in a deep vein, most commonly in the legs or pelvis. A minority of DVTs occur in the arms. Symptoms can include pain, swelling, redness, and enlarged veins in the affected area, but some DVTs have no symptoms. The most common life-threatening concern with DVT is the potential for a clot to embolize (detach from the veins), travel as an embolus through the right side of the heart, and become lodged in a pulmonary artery that supplies blood to the lungs. This is called a pulmonary embolism (PE). DVT and PE comprise the cardiovascular disease of venous thromboembolism (VTE). About two-thirds of VTE manifests as DVT only, with one-third manifesting as PE with or without DVT. The most frequent long-term DVT complication is post-thrombotic syndrome, which can cause pain, swelling, a sensation of heaviness, itching, and in severe cases, ulcers. Recurrent VTE occurs in about 30% of those i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Local Gigantism
Local gigantism or localised gigantism is a condition in which a certain part of the body acquires larger than normal size due to excessive growth of the anatomical structures or abnormal accumulation of substances. It is more common in fingers and toes, where it is termed macrodactyly. However, sometimes an entire limb may be enlarged. Causes Local gigantism may be caused by a heterogeneous group of both congenital and acquired conditions. Congenital Congenital causes include: *Klippel–Trénaunay syndrome *Maffucci syndrome *macrodystrophia lipomatosa *neurofibromatosis, *lipoatrophic diabetes. *Proteus syndrome, which by one theory accounts for the deformities of the Elephant Man Acquired There are a number of acquired causes of local gigantism. A body part can attain bigger size from causes as common as the following: *inflammation, due to trauma or infection *tumors like osteoid osteoma, melorheostosis, and lipofibromatous hamartoma *Arteriovenous malformations occurring ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ABC News
ABC News is the news division of the American broadcast network ABC. Its flagship program is the daily evening newscast ''ABC World News Tonight, ABC World News Tonight with David Muir''; other programs include Breakfast television, morning news-talk show ''Good Morning America'', ''Nightline'', ''Primetime (American TV program), Primetime'', and ''20/20 (American TV program), 20/20'', and Sunday morning talk shows, Sunday morning political affairs program ''This Week (ABC TV series), This Week with George Stephanopoulos''. In addition to the division's television programs, ABC News has radio and digital outlets, including ABC News Radio and ABC News Live, plus various podcasts hosted by ABC News personalities. History Early years ABC began in 1943 as the Blue Network, NBC Blue Network, a radio network that was Corporate spin-off, spun off from NBC, as ordered by the Federal Communications Commission (FCC) in 1942. The reason for the order was to expand competition in radi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Central Lancashire
, mottoeng = "From the Earth to the Sun" , established = as Institution for the Diffusion of Useful Knowledgere-established 1992 (University status granted) , type = Public , chancellor = Ranvir Singh , vice_chancellor = Graham Baldwin , students = () , undergrad = () , postgrad = () , city = Preston (Main)BurnleyCyprusWestlakes, Cumbria , campus = Urban , former_names = Harris Art College, Preston Polytechnic, Lancashire Polytechnic , colours = , website = , logo = , logo_caption = , logo_size = , footnotes = , affiliations = University AllianceUniversities UK , coor = , pushpin_map = United Kingdom Preston central The University of Central Lancashire (abbrevi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
