Madd Aleem
MADD or Madd may refer to: * Mothers Against Drunk Driving, a nonprofit organization in the United States and Canada that seeks to stop drunk driving * Myoadenylate deaminase deficiency or Adenosine monophosphate deaminase deficiency type 1, a metabolic disorder * Multiple acyl-CoA dehydrogenase deficiency, another name for the genetic disorder Glutaric acidemia type 2 * MADD (gene) or MAP kinase-activating death domain protein * Madd, the fruit of ''Saba senegalensis'' * Maladaptive Daydreaming Maladaptive daydreaming, also called excessive daydreaming, is when an individual experiences excessive daydreaming that interferes with daily life. It is a proposed diagnosis of a disordered form of dissociative absorption associated with excessi ...

Mothers Against Drunk Driving
Mothers Against Drunk Driving (MADD) is a non-profit organization in the United States, Canada and Brazil that seeks to stop drunk driving, support those affected by drunk driving, prevent underage drinking, and strive for stricter impaired driving policy, whether that impairment is caused by alcohol or any other drug. The Irving, Texas–based organization was founded on September 5, 1980, in California by Candace Lightner after her 13-year-old daughter, Cari, was killed by a drunk driver. There is at least one MADD office in every state of the United States and at least one in each province of Canada. These offices offer victim services and many resources involving alcohol safety. MADD has claimed that drunk driving has been reduced by half since its founding. Positions According to MADD's website, "The mission of Mothers Against Drunk Driving is to end drunk driving, help fight drugged driving, support the victims of these violent crimes and prevent underage drinking." General ...
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Adenosine Monophosphate Deaminase Deficiency Type 1
Adenosine monophosphate deaminase deficiency type 1 or AMPD1, is a human metabolic disorder in which the body consistently lacks the enzyme AMP deaminase, in sufficient quantities. This may result in exercise intolerance, muscle pain and muscle cramping. The disease was formerly known as myoadenylate deaminase deficiency. In virtually all cases, the deficiency has been caused by an SNP mutation, known as ''rs17602729'' or ''C34T''. While it was initially regarded as a recessive (or purely homozygous) disorder, some researchers have reported the existence of similarly deleterious effects from the heterozygous form of the SNP. In the homozygous form of the mutation, a single genetic base (character) has been changed from cytosine ("C") to thymine ("T") on both strands of Chromosome 1 – in other words, "C;C" has been replaced by "T;T". A rarer but analogous condition, in which two guanine bases ("G;G") bases (in the unmutated form) have been changed to adenine ("A;A") has also been ...
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Multiple Acyl-CoA Dehydrogenase Deficiency
Glutaric acidemia type 2 is an autosomal recessive metabolic disorder that is characterised by defects in the ability of the body to use proteins and fats for energy. Incompletely processed proteins and fats can build up, leading to a dangerous chemical imbalance called acidosis. Genetics Mutations in the ''ETFA'', ''ETFB'', and ''ETFDH'' genes cause glutaric acidemia type II. Mutations in these genes result in a deficiency in one of two enzymes that normally work together in the mitochondria, which are the energy-producing centers of cells. The ETFA and ETFB genes encode two subunits of the enzyme electron transfer flavoprotein, while the ETFDH gene encodes the enzyme electron-transferring-flavoprotein dehydrogenase. When one of these enzymes is defective or missing, the mitochondria cannot function normally, partially broken-down proteins and fats accumulate in the cells and damage them; this damage leads to the signs and symptoms of glutaric acidemia type II. This condit ...
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MADD (gene)
MAP kinase-activating death domain protein is an enzyme that in humans is encoded by the ''MADD'' gene. Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes incl .... The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. ...
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Saba Senegalensis
''Saba senegalensis'', known as ''weda'' in the Mossi language, Moore, French language, French, and English language, English languages, is a fruit-producing plant of the Apocynaceae family, native to the Sahel region of sub-Saharan Africa. It has several common names in various West African Languages. The tree grows predominantly on riverbanks and in woodlands in The Gambia, Guinea-Bissau, Burkina Faso, Senegal, Somalia, Mali and Ivory Coast. It has been observed growing as vine up trees, as a small erect shrub, and oftentimes growing to the size of a large tree. ICRISAT has cited ''S. senegalensis'' as a useful food crop plant and as a tool to combat soil degradation in rural Africa. Fruit The fruit of ''Saba senegalensis'' has a hard yellow peel containing large seeds embedded in a yellowish pulp, having a pleasing acidity similar to that of the tamarind. The flavour has also been compared with that of a mango or a lemon. Drink Natives of the Sahel, Sahel region often u ...
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