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MacFarlan Smith
MacFarlan Smith is a pharmaceutical research company based in Edinburgh, Scotland, founded in 1815. It is part of the Fine Chemical and Catalysts division of Johnson Matthey. Background J.F. Macfarlan J.F. Macfarlan Ltd was founded in 1780 as an apothecary supplier. In 1815 John Fletcher Macfarlan, licentiate of the Royal College of Surgeons, became the owner of the family business, and acquired an apothecary's shop in Edinburgh. He immediately began to manufacture laudanum, a medicine based on opium. In 1830 Macfarlan began a partnership with his former apprentice David Rennie Brown, and so incorporated the business as J.F. Macfarlan and Co Ltd. In 1832 the company began manufacture of morphine acetate (the medicinal version of heroin) and hydrochloride, which led to the development and manufacture of the anaesthetics ether and chloroform. This allowed the company to develop sterile dressings for Joseph Lister, 1st Baron Lister under contract. After acquiring the Abbeyhill chemi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Subsidiary
A subsidiary, subsidiary company or daughter company is a company owned or controlled by another company, which is called the parent company or holding company. Two or more subsidiaries that either belong to the same parent company or having a same management being substantially controlled by same entity/group are called sister companies. The subsidiary can be a company (usually with limited liability) and may be a government- or state-owned enterprise. They are a common feature of modern business life, and most multinational corporations organize their operations in this way. Examples of holding companies are Berkshire Hathaway, Jefferies Financial Group, The Walt Disney Company, Warner Bros. Discovery, or Citigroup; as well as more focused companies such as IBM, Xerox, and Microsoft. These, and others, organize their businesses into national and functional subsidiaries, often with multiple levels of subsidiaries. Details Subsidiaries are separate, distinct legal entities f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Joseph Lister, 1st Baron Lister
Joseph Lister, 1st Baron Lister, (5 April 182710 February 1912) was a British surgeon, medical scientist, experimental pathologist and a pioneer of antiseptic surgery and preventative medicine. Joseph Lister revolutionised the craft of surgery in the same manner that John Hunter revolutionised the science of surgery. From a technical viewpoint, Lister was not an exceptional surgeon, but his research into bacteriology and infection in wounds raised his operative technique to a new plane where his observations, deductions and practices revolutionised surgery throughout the world. Lister's contribution to the fields of physiology, pathology and surgery were four-fold. He promoted the principle of antiseptic surgical care and wound management while working as a surgeon at the Glasgow Royal Infirmary by successfully introducing phenol (then known as carbolic acid) to sterilise surgical instruments, the patient's skin, sutures, the surgeon's hands and the ward. Secondly he r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Navy
The Royal Navy (RN) is the United Kingdom's naval warfare force. Although warships were used by English and Scottish kings from the early medieval period, the first major maritime engagements were fought in the Hundred Years' War against France. The modern Royal Navy traces its origins to the early 16th century; the oldest of the UK's armed services, it is consequently known as the Senior Service. From the middle decades of the 17th century, and through the 18th century, the Royal Navy vied with the Dutch Navy and later with the French Navy for maritime supremacy. From the mid 18th century, it was the world's most powerful navy until the Second World War. The Royal Navy played a key part in establishing and defending the British Empire, and four Imperial fortress colonies and a string of imperial bases and coaling stations secured the Royal Navy's ability to assert naval superiority globally. Owing to this historical prominence, it is common, even among non-Britons, to ref ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Army
The British Army is the principal land warfare force of the United Kingdom, a part of the British Armed Forces along with the Royal Navy and the Royal Air Force. , the British Army comprises 79,380 regular full-time personnel, 4,090 Gurkhas, and 28,330 volunteer reserve personnel. The modern British Army traces back to 1707, with antecedents in the English Army and Scots Army that were created during the Restoration in 1660. The term ''British Army'' was adopted in 1707 after the Acts of Union between England and Scotland. Members of the British Army swear allegiance to the monarch as their commander-in-chief, but the Bill of Rights of 1689 and Claim of Right Act 1689 require parliamentary consent for the Crown to maintain a peacetime standing army. Therefore, Parliament approves the army by passing an Armed Forces Act at least once every five years. The army is administered by the Ministry of Defence and commanded by the Chief of the General Staff. The Brit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Young Simpson
Sir James Young Simpson, 1st Baronet, (7 June 1811 – 6 May 1870) was a Scottish obstetrician and a significant figure in the history of medicine. He was the first physician to demonstrate the anaesthetic properties of chloroform on humans and helped to popularise its use in medicine. Simpson's intellectual interests ranged from archaeology to an almost taboo subject at the time: hermaphroditism. He was an early advocate of the use of midwives in the hospital environment. Many prominent women also consulted him for their gynaecological problems. Simpson wrote ''Homœopathy, its Tenets and Tendencies'' refuting the ideas put forward by Hahnemann. His services as an early founder of gynaecology and proponent of hospital reform were rewarded with a knighthood and by 1847 he had been appointed as physician to the Queen in Scotland. Simpson was a close friend of Sir David Brewster, and was present at his deathbed. His contribution to the understanding of the anaesthetic proper ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloroform
Chloroform, or trichloromethane, is an organic compound with chemical formula, formula Carbon, CHydrogen, HChlorine, Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to PTFE. It is also a precursor to various refrigerants. It is trihalomethane. It is a powerful anesthetic, euphoriant, anxiolytic, and sedative when inhaled or ingested. Structure The molecule adopts a tetrahedral molecular geometry with C3v symmetry group, symmetry. Natural occurrence The total global flux of chloroform through the environment is approximately tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Abiotic processes are also believed to contribute to natural chloroform productions in soils although the mechanism is still unclear. Chloroform volatilizes readily from soil and surface water and undergoes degradation in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lactucarium
Lactucarium is the milky fluid secreted by several species of lettuce, especially ''Lactuca virosa'', usually from the base of the stems. It is known as lettuce opium because of its sedative and analgesic properties. It has also been reported to promote a mild sensation of euphoria. Because it is a latex, lactucarium physically resembles opium, in that it is excreted as a white fluid and can be reduced to a thick smokable solid. History "Lettuce opium" was used by the ancient Egyptians, and was introduced as a drug in the United States as early as 1799. The drug was prescribed and studied extensively in Poland during the nineteenth century, and was viewed as an alternative to opium, weaker but lacking side-effects, such as not being highly addictive, and in some cases preferable. However, early efforts to isolate an active alkaloid were unsuccessful. It is described and standardized in the 1898 United States Pharmacopoeia and 1911 ''British Pharmaceutical Codex'' for use in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James Duncan (surgeon)
James Duncan FRSE FRCS FRCSE (2 November 1810 – 16 August 1866) was a Scottish surgeon and manufacturing chemist responsible for much of the British supply of chloroform in the mid-19th century. From 1839 to 1866 he was Director of Duncan Flockhart & Co one of Scotland’s largest chemical manufacturers. Life He was born in Perth on 2 November 1810, the son of John Duncan (b.1780) founder of Duncan Flockhart & Co. and his wife, Elizabeth Morison. He was educated at Perth Academy then sent to the High School in Edinburgh to be educated. In 1833 his father’s company moved from Perth to Edinburgh, with premises at 52 North Bridge with the family living at 1 Blenheim Place at the top of Leith Walk. Meanwhile Duncan was completing his medical studies at the University of Edinburgh, graduating with an MD in 1834. He was taught surgery by Robert Liston. Due to his rich father his postgraduate studies leading to his MD included studies in France, Germany, Austria and Italy. Upo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
William Flockhart
William Flockhart, L.R.C.S.E. (1808 – 1871) was a Scottish chemist, a pharmacist who provided chloroform to Doctor (later Sir) James Young Simpson for his anaesthesia experiment at 52 Queen Street, Edinburgh on 4 November 1847. This was the first use of this chemical on humans when Simpson tried it on himself and a few friends, and then used it for pain relief in obstetrics, and surgery. This changed medical practice for over a century, according to the British Medical Journal. Career Flockhart had joined John Duncan (also from Kinrosshire, who was 28 years his senior), as a partner in 1833, having started as an apprentice surgeon-apothecary and qualifying as a licenciate of the Royal College of Surgeons Edinburgh in 1830, when he was 22 years old. He did not practise as a surgeon, but with Duncan, worked closely with other doctors in Edinburgh on experimental drugs, which they then refined to improve in purity, following the medical experiments' results. They were both amon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Perth, Scotland
Perth (Scottish English, locally: ; gd, Peairt ) is a city in central Scotland, on the banks of the River Tay. It is the administrative centre of Perth and Kinross council area and the historic county town of Perthshire. It had a population of about 47,430 in 2018. There has been a settlement at Perth since prehistory, prehistoric times. It is a natural mound raised slightly above the flood plain of the Tay, at a place where the river could be crossed on foot at low tide. The area surrounding the modern city is known to have been occupied ever since Mesolithic hunter-gatherers arrived there more than 8,000 years ago. Nearby Neolithic standing stones and circles date from about 4,000 BC, a period that followed the introduction of farming into the area. Close to Perth is Scone Abbey, which formerly housed the Stone of Scone (also known as the Stone of Destiny), on which the King of Scots were traditionally crowned. This enhanced the early importance of the city, and Perth becam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kinross
Kinross (, gd, Ceann Rois) is a burgh in Perth and Kinross, Scotland, around south of Perth and around northwest of Edinburgh. It is the traditional county town of the historic county of Kinross-shire. History Kinross's origins are connected with the nearby Loch Leven and its islands whose history goes back to the 5th century AD. Kinross developed as a staging post on the Great North Road from North Queensferry to Perth. In time, local industry developed and by the early 18th century the town had grown to a population of around 600 people. By the mid-19th century, a thriving wool weaving industry had emerged. Kinross Town Hall was completed in 1841. Location and transport The site of the original Pre-Reformation parish church and churchyard are located down a small wynd overlooking Loch Leven, a little away from the town. The church was dedicated to St. Serf and was under control of Dunfermline Abbey. Noteworthy ministers included John Colden from 1593 to 1640 and his so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strychnine
Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the eyes or mouth, causes poisoning which results in muscular convulsions and eventually death through asphyxia. While it is no longer used medicinally, it was used historically in small doses to strengthen muscle contractions, such as a heart and bowel stimulant and performance-enhancing drug. The most common source is from the seeds of the ''Strychnos nux-vomica'' tree. Biosynthesis Strychnine is a terpene indole alkaloid belonging to the ''Strychnos'' family of '' Corynanthe'' alkaloids, and it is derived from tryptamine and secologanin. The biosynthesis of strychine was solved in 2022. The enzyme, strictosidine synthase, catalyzes the condensation of tryptamine and secologanin, followed by a Pictet-Spengler reaction to form strictosidine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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