MS-377
MS-377 is a selective antagonist of the sigma-1 receptor. It possesses anti-psychotic properties. Properties MS-377 acts selectively at the sigma-1 receptor as an antagonist. It does not act on dopamine or serotonin receptors unlike most anti-psychotics. Tests have shown that MS-377 could displace ligand binding from the sigma-1 receptor, but did this not happen at the sigma-2, 5-HT2 and D2 receptors, suggesting that it is selective for the sigma-1 receptor. Despite not acting at serotonin and dopamine receptors, it still affects those monoamine systems. It has been shown that MS-377 reduced the release of serotonin and dopamine induced by PCP. It has also been shown to decrease methamphetamine Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamph ... behavioral sensitization, this i ...
[...More Info...]       [...Related Items...]     OR:     [Wikipedia]   [Google]   [Baidu]