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MMP 2
Gelatinase A, also known as MMP2 (, ''72-kDa gelatinase'', ''matrix metalloproteinase 2'', ''type IV collagenase'', ''3/4 collagenase'', ''matrix metalloproteinase 5'', ''72 kDa gelatinase type A'', ''collagenase IV'', ''collagenase type IV'', ''MMP 2'', ''type IV collagen metalloproteinase'', ''type IV collagenase/gelatinase'') is an enzyme. This enzyme catalysis, catalyses the following chemical reaction : Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln This secreted endopeptidase belongs to the peptidase family M10. References External links * {{Portal bar, Biology, border=no EC 3.4.24 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MMP2
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the ''MMP2'' gene. The ''MMP2'' gene is located on chromosome 16 at position 12.2. Function Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Activation Activation of MMP-2 requires proteolytic processing. A complex of membrane type 1 MMP (MT1-MMP/MMP14) and tissue inhibit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |