|
MB-MDA-468
MDA-MB-468 is a cell line that was isolated from a 51-year-old female human in 1977, and is commonly used in breast cancer research. MDA-MB-468 cells were extracted from a pleural effusion of mammary gland and breast tissues, and have proven useful for the study of metastasis, migration, and breast cancer proliferation. The cell line was isolated in 1977 by Relda Cailleau, et al., from a pleural effusion of a 51-year-old Black female patient with metastatic adenocarcinoma Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ) (AC) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or ... of the breast. Although the tissue donor was heterozygous for G6PD alleles, the cell line consistently showed only the G6PD A phenotype. MDA-MB-468 cells have a modal chromosome number of 64, though the actual number can vary from 60 to 67 in different cells. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Line
An immortalised cell line is a population of cells from a multicellular organism which would normally not proliferate indefinitely but, due to mutation, have evaded normal cellular senescence and instead can keep undergoing division. The cells can therefore be grown for prolonged periods ''in vitro''. The mutations required for immortality can occur naturally or be intentionally induced for experimental purposes. Immortal cell lines are a very important tool for research into the biochemistry and cell biology of multicellular organisms. Immortalised cell lines have also found uses in biotechnology. An immortalised cell line should not be confused with stem cells, which can also divide indefinitely, but form a normal part of the development of a multicellular organism. Relation to natural biology and pathology There are various immortal cell lines. Some of them are normal cell lines (e.g. derived from stem cells). Other immortalised cell lines are the ''in vitro'' equivalent ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |