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Montreal Experiments
The Montreal experiments were a series of experiments, initially aimed to treat schizophrenia by changing memories and erasing the patients' thoughts using Donald Ewen Cameron's method of “psychic driving”, as well as drug-induced sleep, intensive electroconvulsive therapy, sensory deprivation and Thorazine. The experiments were conducted at the Allan Memorial Institute of McGill University between 1957 and 1964 by the Scottish psychiatrist Donald Ewen Cameron and funded by the Central Intelligence Agency, CIA as part of Project MKUltra, which lasted until 1973 and was only revealed to the public in 1975. The patients of this experiment expected positive changes from Cameron's treatment. However, these patients suffered severely under conditions that were not in accordance with human rights. Not only the patients but also their families show long lasting effects on their mental health. Some of these symptoms include retrograde amnesia as well as impairments in every day life abi ...
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Schizophrenia
Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdrawal, decreased emotional expression, and apathy. Symptoms typically develop gradually, begin during young adulthood, and in many cases never become resolved. There is no objective diagnostic test; diagnosis is based on observed behavior, a history that includes the person's reported experiences, and reports of others familiar with the person. To be diagnosed with schizophrenia, symptoms and functional impairment need to be present for six months (DSM-5) or one month (ICD-11). Many people with schizophrenia have other mental disorders, especially substance use disorders, depressive disorders, anxiety disorders, and obsessive–compulsive disorder. About 0.3% to 0.7% of people are diagnosed with schizophrenia during their lifetime. In 2 ...
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Brandon, Manitoba
Brandon () is the second-largest city in the province of Manitoba, Canada. It is located in the southwestern corner of the province on the banks of the Assiniboine River, approximately west of the provincial capital, Winnipeg, and east of the Saskatchewan border. Brandon covers an area of with a population of 51,313, and a census metropolitan area population of 54,268. It is the primary hub of trade and commerce for the Westman Region as well as parts of southeastern Saskatchewan and northern North Dakota, an area with a combined population of over 180,000 people. The City of Brandon was incorporated in 1882, having a history rooted in the Assiniboine River fur trade as well as its role as a major junction on the Canadian Pacific Railway. Known as ''The Wheat City'', Brandon's economy is predominantly associated with agriculture; however, it also has strengths in health care, manufacturing, food processing, education, business services, and transportation. Brandon is an integ ...
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Depression (mood)
Depression is a mental state of low mood and aversion to activity, which affects more than 280 million people of all ages (about 3.5% of the global population). Classified medically as a mental and behavioral disorder, the experience of depression affects a person's thoughts, behavior, motivation, feelings, and sense of well-being. The core symptom of depression is said to be anhedonia, which refers to loss of interest or a loss of feeling of pleasure in certain activities that usually bring joy to people. Depressed mood is a symptom of some mood disorders such as major depressive disorder and dysthymia; it is a normal temporary reaction to life events, such as the loss of a loved one; and it is also a symptom of some physical diseases and a side effect of some drugs and medical treatments. It may feature sadness, difficulty in thinking and concentration and a significant increase or decrease in appetite and time spent sleeping. People experiencing depression may have ...
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Largactil
Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, severe behavioral problems in children including those with attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given orally (by mouth), by intramuscular injection (injection into a muscle), or intravenously (injection into a vein). Chlorpromazine is in the typical antipsychotic class, and, chemically, is one of the phenothiazines. Its mechanism of action is not entirely clear but believed to be related to its ability as a dopamine antagonist. It also has anti-serotonergic and antihistaminergic properties. Common side effects include movement problems, sleepiness, dry mouth, low blood pressure upon standing, and increased w ...
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Sodium Amytal
Amobarbital (formerly known as amylobarbitone or sodium amytal as the soluble sodium salt) is a drug that is a barbiturate derivative. It has sedative-hypnotic properties. It is a white crystalline powder with no odor and a slightly bitter taste. It was first synthesized in Germany in 1923. It is considered a short to intermediate acting barbiturate. If amobarbital is taken for extended periods of time, physiological and psychological dependence can develop. Amobarbital withdrawal mimics delirium tremens and may be life-threatening. Amobarbital was manufactured by Eli Lilly and Company in the US under the brand name Amytal in bright blue bullet shaped capsules (known as Pulvules) or pink tablets (known as Diskets) containing 50, 100, or 200 milligrams of the drug. The drug was also manufactured generically. Amobarbital was widely misused, known as "Blue Heavens" on the street. Amytal, as well as Tuinal, a combination drug containing equal quantities of secobarbital and amobarbit ...
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Curare
Curare ( /kʊˈrɑːri/ or /kjʊˈrɑːri/; ''koo-rah-ree'' or ''kyoo-rah-ree'') is a common name for various alkaloid arrow poisons originating from plant extracts. Used as a paralyzing agent by indigenous peoples in Central and South America for hunting and for therapeutic purposes, curare only becomes active when it contaminates a wound. These poisons cause weakness of the skeletal muscles and, when administered in a sufficient dose, eventual death by asphyxiation due to paralysis of the diaphragm. Curare is prepared by boiling the bark of one of the dozens of plant sources, leaving a dark, heavy paste that can be applied to arrow or dart heads. In medicine, curare has been used as a treatment for tetanus or strychnine poisoning and as a paralyzing agent for surgical procedures. History The word 'curare' is derived from ''wurari'', from the Carib language of the Macusi of Guyana. It has its origins in the Carib phrase "mawa cure" meaning of the Mawa vine, scienti ...
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Donald Hebb
Donald Olding Hebb (July 22, 1904 – August 20, 1985) was a Canadian psychologist who was influential in the area of neuropsychology, where he sought to understand how the function of neurons contributed to psychological processes such as learning. He is best known for his theory of Hebbian learning, which he introduced in his classic 1949 work ''The Organization of Behavior''. He has been described as the father of neuropsychology and neural networks. A ''Review of General Psychology'' survey, published in 2002, ranked Hebb as the 19th most cited psychologist of the 20th century. His views on learning described behavior and thought in terms of brain function, explaining cognitive processes in terms of connections between neuron assemblies. Early life Donald Hebb was born in Chester, Nova Scotia, the oldest of four children of Arthur M. and M. Clara (Olding) Hebb, and lived there until the age of 16, when his parents moved to Dartmouth, Nova Scotia. Hebb's parents were both med ...
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Treatment-resistant Depression
Treatment-resistant depression is a term used in psychiatry to describe people with major depressive disorder (MDD) who do not respond adequately to a course of appropriate antidepressant medication within a certain time. Definitions of treatment-resistant depression vary, and they do not include a resistance to psychological therapies. Inadequate response has most commonly been defined as less than 50% reduction in depressive symptoms) following treatment with at least one antidepressant medication, although definitions vary widely. Some factors that contribute to inadequate treatment are: a history of repeated or severe adverse childhood experiences, early discontinuation of treatment, insufficient dosage of medication, patient noncompliance, misdiagnosis, cognitive impairment, low income and other socio-economic variables, and concurrent medical conditions, including comorbid psychiatric disorders. Cases of treatment-resistant depression may also be referred to by which medica ...
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ECT Machine 03
ECT may refer to: Educational institutions * École Canadienne de Tunis, a school in Tunis, Tunisia * Emirates College of Technology, in Abu Dhabi Government and politics * Catalan Workers' Left ( ca, Esquerra Catalana dels Treballadors, link=no), a defunct political party in France * Correios, the Brazilian postal service and postal administration * Election Commission of Thailand, the election management body of Thailand * Energy Charter Treaty, an international agreement guaranteeing investors in energy projects Medicine and psychology * Ecarin clotting time * Ectomesenchymal chondromyxoid tumor * Electroconvulsive therapy * Elementary cognitive task * Emission computed tomography * Expectation confirmation theory Religion * Eternal conscious torment, a view of Hell in Christianity * '' Evangelicals and Catholics Together'', an ecumenical document Technology * ECN-capable transport, a transport layer capable of using Explicit Congestion Notification * Eddy ...
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Hallucinogenic Drugs
Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorized as either being psychedelics, dissociatives, or deliriants. However, certain hallucinogens such as Fly agaric as well as other gabaergic hallucinogenics are more often considered to technically be hypnotics, therefore indicating another separate subcategory of drugs which can substantially alter visual perception. Etymology The word ''hallucinogen'' is derived from the word ''hallucination''. The term ''hallucinate'' dates back to around 1595–1605, and is derived from the Latin ''hallūcinātus'', the past participle of ''(h)allūcināri'', meaning "to wander in the mind." Characteristics Leo Hollister gave five criteria for classifying a drug as hallucinogenic.Glennon RA. Classical drugs: an introductory overview. In Lin GC and G ...
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Thorazine
Chlorpromazine (CPZ), marketed under the brand names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, severe behavioral problems in children including those with attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given orally (by mouth), by intramuscular injection (injection into a muscle), or intravenously (injection into a vein). Chlorpromazine is in the typical antipsychotic class, and, chemically, is one of the phenothiazines. Its mechanism of action is not entirely clear but believed to be related to its ability as a dopamine antagonist. It also has anti-serotonergic and antihistaminergic properties. Common side effects include movement problems, sleepiness, dry mouth, low blood pressure upon standing, and increased we ...
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American Psychiatric Association
The American Psychiatric Association (APA) is the main professional organization of psychiatrists and trainee psychiatrists in the United States, and the largest psychiatric organization in the world. It has more than 37,000 members are involved in psychiatric practice, research, and academia representing a diverse population of patients in more than 100 countries. The association publishes various journals and pamphlets, as well as the ''Diagnostic and Statistical Manual of Mental Disorders'' (DSM). The DSM codifies psychiatric conditions and is used mostly in the United States as a guide for diagnosing mental disorders. The organization has its headquarters in Washington, DC. History At a meeting in 1844 in Philadelphia, thirteen superintendents and organizers of insane asylums and hospitals formed the Association of Medical Superintendents of American Institutions for the Insane (AMSAII). The group included Thomas Kirkbride, creator of the asylum model which was used thr ...
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