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Microtentacle
Microtentacles are microtubule-based membrane protrusions that occur in detached cells. They were discovered by scientists studying metastatic breast cancer cells at the University of Maryland, Baltimore. These novel structures are distinct from classical actin based extensions of adherent cells, persist for days in breast tumor lines that are resistant to apoptosis, and aid in the reattachment to matrix or cell monolayers. The formation of microtentacles (McTNs) in detached or circulating tumor cells may promote seeding of bloodborne metastatic disease. References * * * * * * * *{{cite journal , last1 = Whipple , first1 = R.A. , last2 = Cheung , first2 = A.M. , last3 = Martin , first3 = S.S. , year = 2007 , title = Detyrosinated microtubule protrusions in suspended mammary epithelial cells promote reattachment , journal = Experimental Cell Research , volume = 313 , issue = 7, pages = 1326–36 , doi = 10.1016/j.yexcr.2007.02.001 , pmid=17359970 , pmc=3132414 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microtubule
Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm and have an inner diameter between 11 and 15 nm. They are formed by the polymerization of a dimer of two globular proteins, alpha and beta tubulin into protofilaments that can then associate laterally to form a hollow tube, the microtubule. The most common form of a microtubule consists of 13 protofilaments in the tubular arrangement. Microtubules play an important role in a number of cellular processes. They are involved in maintaining the structure of the cell and, together with microfilaments and intermediate filaments, they form the cytoskeleton. They also make up the internal structure of cilia and flagella. They provide platforms for intracellular transport and are involved in a variety of cellular processes, including the movement of secretory vesicles, organell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metastatic
Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor. The newly pathological sites, then, are metastases (mets). It is generally distinguished from cancer invasion, which is the direct extension and penetration by cancer cells into neighboring tissues. Cancer occurs after cells are genetically altered to proliferate rapidly and indefinitely. This uncontrolled proliferation by mitosis produces a primary heterogeneic tumour. The cells which constitute the tumor eventually undergo metaplasia, followed by dysplasia then anaplasia, resulting in a malignant phenotype. This malignancy allows for invasion into the circulation, followed by invasion to a second site for tumorigenesis. Some cancer cells known as circulating tumor cells acquire the ability to penetrate the walls of lymphatic or blood vessels, after which they are able ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. Risk factors for developing breast cancer include obesity, a lack of physical exercise, alcoholism, hormone replacement therapy during menopause, ionizing radiation, an early age at first menstruation, having children late in life or not at all, older age, having a prior history of breast cancer, and a family history of breast cancer. About 5–10% of cases are the result of a genetic predisposition inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Maryland, Baltimore
The University of Maryland, Baltimore (UMB) is a public university in Baltimore, Maryland. Founded in 1807, it comprises some of the oldest professional schools of dentistry, law, medicine, pharmacy, social work and nursing in the United States. It is the original campus of the University System of Maryland and has a strategic partnership with the University of Maryland, College Park. Located on 71 acres (242,811 m2) on the west side of downtown Baltimore, it is part of the University System of Maryland. UMB's mission is to improve the human condition and serve the public good of Maryland and society at-large through education, research, clinical care, and service. In 2012, the University of Maryland, Baltimore and the flagship University of Maryland, College Park united under the MPowering the State initiative to leverage the strengths of both institutions. The University of Maryland Strategic Partnership Act of 2016 officially formalized the partnership as it has successf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
