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Mescaline Go-Go
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sources It occurs naturally in several species of cacti. It is also found in small amounts in certain members of the bean family, Fabaceae, including ''Acacia berlandieri''. However those claims concerning ''Acacia'' species have been challenged and have been unsupported in any additional analysis. History and use Peyote has been used for at least 5,700 years by Indigenous peoples of the Americas in Mexico. Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador. While religious and ceremonial peyote use was widespread in the Aztec empire and northern Me ...
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Oral
The word oral may refer to: Relating to the mouth * Relating to the mouth, the first portion of the alimentary canal that primarily receives food and liquid **Oral administration of medicines ** Oral examination (also known as an oral exam or oral test), a practice in many schools and disciplines in which an examiner poses questions to the student in spoken form ** Oral hygiene, practices involved in cleaning the mouth and preventing disease **Oral medication **Oral rehydration therapy, a simple treatment for dehydration associated with diarrhea **Oral sex, sexual activity involving the stimulation of genitalia by use of the mouth, tongue, teeth or throat. **Oral stage, a human development phase in Freudian developmental psychology **Oral tradition, cultural material and tradition transmitted orally from one generation to another **Oralism, the education of deaf students through oral language by using lip reading, and mimicking of mouth shapes and breathing patterns **Speech communi ...
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Echinopsis Santaensis
''Echinopsis'' is a large genus of cacti native to South America, sometimes known as hedgehog cactus, sea-urchin cactus or Easter lily cactus. One small species, ''E. chamaecereus'', is known as the peanut cactus. The 128 species range from large and treelike types to small globose cacti. The name derives from ''echinos'' hedgehog or sea urchin, and ''opsis'' appearance, a reference to these plants' dense coverings of spines. They are remarkable for the great size, length of tube, and beauty of their flowers, which, borne upon generally small and dumpy stems, appear much larger and more attractive than would be expected. Taxonomy Studies in the 1970s and 1980s resulted in several formerly separate genera being absorbed into ''Echinopsis'': Some have proposed merging ''Rebutia'' as well. Like several other taxonomic changes in Cactaceae, this one has not been universally accepted. Amateur and professional growers still use names like ''Echinopsis'' (in the older sense), '' ...
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Phenylalanine
Phenylalanine (symbol Phe or F) is an essential α-amino acid with the formula . It can be viewed as a benzyl group substituted for the methyl group of alanine, or a phenyl group in place of a terminal hydrogen of alanine. This essential amino acid is classified as neutral, and nonpolar because of the inert and hydrophobic nature of the benzyl side chain. The L-isomer is used to biochemically form proteins coded for by DNA. Phenylalanine is a precursor for tyrosine, the monoamine neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), and the skin pigment melanin. It is encoded by the codons UUU and UUC. Phenylalanine is found naturally in the milk of mammals. It is used in the manufacture of food and drink products and sold as a nutritional supplement for its analgesic and antidepressant effects. It is a direct precursor to the neuromodulator phenethylamine, a commonly used dietary supplement. As an essential amino acid, phenylalanine is n ...
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Tyrosine
-Tyrosine or tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins. It is a non-essential amino acid with a polar side group. The word "tyrosine" is from the Greek ''tyrós'', meaning ''cheese'', as it was first discovered in 1846 by German chemist Justus von Liebig in the protein casein from cheese. It is called tyrosyl when referred to as a functional group or side chain. While tyrosine is generally classified as a Hydrophobe, hydrophobic amino acid, it is more hydrophilic than phenylalanine. It is Genetic code, encoded by the Genetic code#Codons, codons UAC and UAU in messenger RNA. Functions Aside from being a proteinogenic amino acid, tyrosine has a special role by virtue of the phenol functionality. It occurs in proteins that are part of signal transduction processes and functions as a receiver of phosphate groups that are transferred by way of protein kinases. Phosphorylation of the hyd ...
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Biosynthesis
Biosynthesis is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms. In biosynthesis, simple compounds are modified, converted into other compounds, or joined to form macromolecules. This process often consists of metabolic pathways. Some of these biosynthetic pathways are located within a single cellular organelle, while others involve enzymes that are located within multiple cellular organelles. Examples of these biosynthetic pathways include the production of lipid membrane components and nucleotides. Biosynthesis is usually synonymous with anabolism. The prerequisite elements for biosynthesis include: precursor compounds, chemical energy (e.g. ATP), and catalytic enzymes which may require coenzymes (e.g.NADH, NADPH). These elements create monomers, the building blocks for macromolecules. Some important biological macromolecules include: proteins, which are composed of amino acid monomers joined via peptide bon ...
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Convention On Psychotropic Substances
The Convention on Psychotropic Substances of 1971 is a United Nations treaty designed to control psychoactive drugs such as #Amphetamine-type stimulants, amphetamine-type stimulants, barbiturates, benzodiazepines, and Psychedelic drug, psychedelics signed in Vienna, Austria on 21 February 1971. The Single Convention on Narcotic Drugs of 1961 did not ban the many newly discovered psychotropics, since its scope was limited to drugs with Cannabis (drug), cannabis, coca and opium-like effects. During the 1960s such recreational drug use, drugs became widely available, and government authorities opposed this for numerous reasons, arguing that along with negative health effects, drug use led to lowered moral standards. The Convention, which contains import and export restrictions and other rules aimed at limiting drug use to scientific and medical purposes, came into force on 16 August 1976. As of 2013, 183 member states of the United Nations, member states are Parties to the treaty. ...
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Humphry Osmond
Humphry Fortescue Osmond (1 July 1917 – 6 February 2004) was an English psychiatrist who expatriated to Canada, then moved to work in the United States. He is known for inventing the word '' psychedelic'' and for his research into interesting and useful applications for psychedelic drugs. Osmond also explored aspects of the psychology of social environments, in particular how they influenced welfare or recovery in mental institutions. Biography Osmond was born in Surrey, England, and educated at Haileybury. As a young man, he worked for an architect and attended Guy's Hospital Medical School at King's College London. While active as a surgeon-lieutenant in the Navy during World War II, Osmond trained to become a psychiatrist. Work with psychedelics After the war, Osmond joined the psychiatric unit at St George's Hospital, London, where he rose to become senior registrar. His time at the hospital proved pivotal in three respects: it was where he met his wife Amy "Jane" Rof ...
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Panorama (TV Series)
A panorama (formed from Greek πᾶν "all" + ὅραμα "view") is any wide-angle view or representation of a physical space, whether in painting, drawing, photography, film, seismic images, or 3D modeling. The word was originally coined in the 18th century by the English (Irish descent) painter Robert Barker to describe his panoramic paintings of Edinburgh and London. The motion-picture term ''panning'' is derived from ''panorama''. A panoramic view is also purposed for multimedia, cross-scale applications to an outline overview (from a distance) along and across repositories. This so-called "cognitive panorama" is a panoramic view over, and a combination of, cognitive spaces used to capture the larger scale. History The device of the panorama existed in painting, particularly in murals, as early as 20 A.D., in those found in Pompeii, as a means of generating an immersive "panoptic" experience of a vista. Cartographic experiments during the Enlightenment era prece ...
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Christopher Mayhew
Christopher Paget Mayhew, Baron Mayhew (12 June 1915 – 7 January 1997) was a British politician who was a Labour Member of Parliament (MP) from 1945 to 1950 and from 1951 to 1974, when he left the Labour Party to join the Liberals. In 1981 Mayhew received a life peerage and was raised to the House of Lords as Baron Mayhew. He is most known for his central role in founding the Information Research Department (IRD), a secret wing of the UK Foreign Office dedicated to Cold War propaganda. Early life Christopher Paget Mayhew was the son of Sir Basil Mayhew of Felthorpe Hall, Norwich. Mayhew attended Haileybury and Christ Church, Oxford, as an exhibitioner. In 1934 he holidayed in Moscow. While he was at Oxford, he became President of the Oxford Union. He was commissioned into the Intelligence Corps in 1940, rising to the rank of Major. Political career Mayhew was elected to Parliament for the constituency of South Norfolk in the general election of 1945. In 1945, Mayhew b ...
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Ernst Späth
Ernst Späth (; 14 May 1886 in Moravský Beroun – 30 September 1946 in Zurich) was an Austrian chemist, specializing in natural products. Life Späth was the first to synthesise mescaline and was one of the first to synthesize cuscohygrine on a small scale with Hans Tuppy. He lost everything in World War II, and died with no money. His former student Percy Lavon Julian returned to Vienna, paid for his funeral, and commissioned a bust of Späth, which is still displayed in the foyer of the ''Faculty of Chemistry'' of the University of Vienna The University of Vienna (german: Universität Wien) is a public research university located in Vienna, Austria. It was founded by Duke Rudolph IV in 1365 and is the oldest university in the German-speaking world. With its long and rich histor .... A second cast of the bust was erected in 1961 in the ''Arkadenhof'' of the University of Vienna. References Biography * Publications * Austrian chemists 1886 births 1946 deat ...
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Arthur Heffter
Arthur Carl Wilhelm Heffter (15 June 1859, in Leipzig – 8 February 1925, in Berlin) was a German pharmacologist and chemist. He was the first chairman of the German Society of Pharmacologists, and was largely responsible for the first ''Handbook of Experimental Pharmacology''. He isolated mescaline from the peyote cactus in 1897, the first such isolation of a naturally occurring psychedelic substance in pure form. In addition, he conducted experiments on its effects by comparing the effects of peyote and mescaline on himself. Works * ''Die chronische Bleivergiftung im Maler-Gewerbe''. .l.190Digital editionby the University and State Library Düsseldorf. * ''Die Auffindung von Arzneimitteln''. Hirschwald, Berlin 191Digital editionby the University and State Library Düsseldorf. See also * Heffter Research Institute The Heffter Research Institute is a 501(c)(3) nonprofit organization that promotes research with classic hallucinogens and psychedelics, predominantly psilocy ...
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Huichol People
The Huichol or Wixárika are an indigenous people of Mexico and the United States living in the Sierra Madre Occidental range in the states of Nayarit, Jalisco, Zacatecas, and Durango, as well as in the United States in the states of California, Arizona, New Mexico, and Texas. They are best known to the larger world as the ''Huichol'', although they refer to themselves as ''Wixáritari'' ("the people") in their native Huichol language. The adjectival form of ''Wixáritari'' and name for their own language is ''Wixárika''. The ethnonym huichol comes from the adaptation to the language Nahuatl from the ethnonym wixarika, due to that in the language wixarika the a can be spoken like o; r y l are allophones, and the pronunciation of x, that was a sibilant, was read as an affricate, tz, between the 17th and 18th centuries (time period in which the word could have been borrowed), but the loss of the syllable -ka resulted in huitzol en náhuatl, and its hispanicization, wirraricas. T ...
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