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McEwen Centre For Regenerative Medicine
The McEwen Centre for Regenerative Medicine was established at University Health Network in Toronto in 2003, with a donation from Rob and Cheryl McEwen, which they matched in 2006 with a second donation. The McEwen Centre's vision is to be a world-renowned centre for stem cell biology and regenerative medicine. To achieve this ambitious goal, the team of McEwen Investigators is working together to accelerate the development of more effective treatments for conditions such as heart disease, diabetes mellitus, respiratory disease and spinal cord injury. The McEwen Centre is based in the heart of Toronto's Discovery District at the MaRS Centre/Toronto Medical Discovery Tower. The current Director of the McEwen Center for Regenerative Medicine is Prof. Gordon Keller,University Health Networ"Research Profile: Gordon Keller, PhD"/ref> Canada Research Chair in Embryonic Stem Cell Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blasto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Health Network
University Health Network (UHN) is a public research and teaching hospital network in Toronto, Ontario, Canada. It is the largest health research organization in Canada and ranks first in Canada for total research funding. It was named Canada's top research hospital by Research Infosource from 2015 to 2021. The network includes three acute care hospitals – Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre – the Toronto Rehabilitation Institute, and The Michener Institute, a post-secondary institution granting diplomas and certificates in health sciences and leadership. In the 2019-2020 fiscal year, there were over 39,000 acute inpatient stays and close to 121,000 emergency department visits across the three acute care hospitals. History A series of mergers over many years has resulted in the UHN in its current form. In 1986, the Toronto Western Hospital and the Toronto General Hospital merged to form The Toronto Hospital. This was followed in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toronto
Toronto ( ; or ) is the capital city of the Canadian province of Ontario. With a recorded population of 2,794,356 in 2021, it is the most populous city in Canada and the fourth most populous city in North America. The city is the anchor of the Golden Horseshoe, an urban agglomeration of 9,765,188 people (as of 2021) surrounding the western end of Lake Ontario, while the Greater Toronto Area proper had a 2021 population of 6,712,341. Toronto is an international centre of business, finance, arts, sports and culture, and is recognized as one of the most multicultural and cosmopolitan cities in the world. Indigenous peoples have travelled through and inhabited the Toronto area, located on a broad sloping plateau interspersed with rivers, deep ravines, and urban forest, for more than 10,000 years. After the broadly disputed Toronto Purchase, when the Mississauga surrendered the area to the British Crown, the British established the town of York in 1793 and later designat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rob McEwen
Rob McEwen, CM (born April 15, 1950) is a Canadian businessman. He is the chairman and chief executive officer of McEwen Mining and was the founder and former chairman and chief executive officer of Goldcorp. In January 2019, Goldcorp merged with Newmont creating Newmont Goldcorp Corporation, the second largest gold mining company in the world. McEwen followed his father into the investment industry and also developed a passion for gold. As of 2016 he is one of the top one-hundred wealthiest Canadians, with an estimated personal net worth over $800 million. McEwen devised an innovative approach to exploration when he published maps and geological data on one of Goldcorp's properties and invited scientists and engineers around the world to analyze the data and submit drilling plans to Goldcorp to help it find its next gold deposit. Normally such data is considered proprietary and confidential in the exploration and mining industry and some of Mr. McEwen's colleagues were horrif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cheryl McEwen
Cheryl A. McEwen (née Mason) is a Toronto philanthropist and entrepreneur who, in 2014, founded Make My Day Foods Inc., manufacturer of the Veggie Puck. In 1991, McEwen, with her brother, Darren Mason, and sister, Beverley Lerner, co-founded upscale Andrews Department Store in Toronto, which her siblings– both high-profile retail business leaders –expanded and continue to own and operate under Darren Mason & Associates Ltd. Darren launched the "Eyes on the Road" campaign in 2016, at St. Andrew's College, the alma mater he shares with his sister's spouse, mining magnate Rob McEwen. Cheryl has served as Vice-Chair of the Toronto General & Western Hospital Foundation Board since 2005, which is part of the University Health Network. The McEwens co-founded the McEwen Centre for Regenerative Medicine. In 2013, the couple were each awarded the Queen Elizabeth II Diamond Jubilee Medal The Queen Elizabeth II Diamond Jubilee Medal (french: Médaille du jubilé de diamant de la ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stem Cell
In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms, but they have slightly different properties in each. They are usually distinguished from progenitor cells, which cannot divide indefinitely, and precursor or blast cells, which are usually committed to differentiating into one cell type. In mammals, roughly 50–150 cells make up the inner cell mass during the blastocyst stage of embryonic development, around days 5–14. These have stem-cell capability. ''In vivo'', they eventually differentiate into all of the body's cell types (making them pluripotent). This process starts with the differentiation into the three germ layers – the ectoderm, mesoderm and endoderm – at the gastrulation stage. However ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regenerative Medicine
Regenerative medicine deals with the "process of replacing, engineering or regenerating human or animal cells, tissues or organs to restore or establish normal function". This field holds the promise of engineering damaged tissues and organs by stimulating the body's own repair mechanisms to functionally heal previously irreparable tissues or organs. Regenerative medicine also includes the possibility of growing tissues and organs in the laboratory and implanting them when the body cannot heal itself. When the cell source for a regenerated organ is derived from the patient's own tissue or cells, the challenge of organ transplant rejection via immunological mismatch is circumvented. This approach could alleviate the problem of the shortage of organs available for donation. Some of the biomedical approaches within the field of regenerative medicine may involve the use of stem cells. Examples include the injection of stem cells or progenitor cells obtained through directed differenti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Heart Disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. CVD includes coronary artery diseases (CAD) such as angina and myocardial infarction (commonly known as a heart attack). Other CVDs include stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, abnormal heart rhythms, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis. The underlying mechanisms vary depending on the disease. It is estimated that dietary risk factors are associated with 53% of CVD deaths. Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis. This may be caused by high blood pressure, smoking, diabetes mellitus, lack of exercise, obesity, high blood cholesterol, poor diet, excessive alcohol consumption, and poor sleep, among other things. High blood pressure is estimated to account for approximatel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diabetes Mellitus
Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased appetite. If left untreated, diabetes can cause many health complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death. Serious long-term complications include cardiovascular disease, stroke, chronic kidney disease, foot ulcers, damage to the nerves, damage to the eyes, and cognitive impairment. Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. Insulin is a hormone which is responsible for helping glucose from food get into cells to be used for energy. There are three main types of diabetes mellitus: * Type 1 diabetes results from failure of the pancreas to produce enough insulin due to lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Respiratory Disease
Respiratory diseases, or lung diseases, are pathology, pathological conditions affecting the organs and tissues that make gas exchange difficult in Breathing, air-breathing animals. They include conditions of the respiratory tract including the trachea, bronchi, bronchioles, Pulmonary alveolus, alveoli, pulmonary pleurae, pleurae, pleural cavity, the nerves and muscles of respiration. Respiratory diseases range from mild and self-limiting, such as the common cold, influenza, and pharyngitis to life-threatening diseases such as bacterial pneumonia, pulmonary embolism, tuberculosis, Asthma, acute asthma, lung cancer, and severe acute respiratory syndromes, such as Coronavirus disease 2019, COVID-19. Respiratory diseases can be classified in many different ways, including by the organ or tissue involved, by the type and pattern of associated signs and symptoms, or by the cause of the disease. The study of respiratory disease is known as pulmonology. A physician who specializes in res ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spinal Cord Injury
A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. Symptoms may include loss of muscle function, sensation, or autonomic function in the parts of the body served by the spinal cord below the level of the injury. Injury can occur at any level of the spinal cord and can be ''complete'', with a total loss of sensation and muscle function at lower sacral segments, or ''incomplete'', meaning some nervous signals are able to travel past the injured area of the cord up to the Sacral S4-5 spinal cord segments. Depending on the location and severity of damage, the symptoms vary, from numbness to paralysis, including bowel or bladder incontinence. Long term outcomes also range widely, from full recovery to permanent tetraplegia (also called quadriplegia) or paraplegia. Complications can include muscle atrophy, loss of voluntary motor control, spasticity, pressure sores, infections, and breathing problems. In the majority of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Discovery District
The Discovery District is one of the commercial districts in Downtown Toronto, Ontario, Canada. It has a high concentration of hospitals and research institutions, particularly those related to biotechnology. The district is roughly bounded by Bloor Street on the north, Bay Street on the east, Dundas Street on the south, and Spadina Avenue on the west. Characteristics The area includes the main campus of the University of Toronto, as well as university affiliated leading health-care facilities such as the Hospital for Sick Children, Toronto General Hospital, Princess Margaret Cancer Centre, Mount Sinai Hospital, Toronto Rehabilitation Institute and the MaRS Discovery District. These buildings are concentrated along the section of University Avenue between Dundas and College Streets. An extension of the Discovery District is located at the southwest block of Kensington Market at the intersection of Dundas and Bathurst Streets, where the Krembil Research Institute of the Toronto ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MaRS Discovery District
MaRS Discovery District is a not-for-profit corporation founded in Toronto, Ontario, Canada in 2000. Its stated goal is to commercialize publicly funded medical research and other technologies with the help of local private enterprises and as such is a public-private partnership. As part of its mission MaRS says, "MaRS helps create successful global businesses from Canada's science, technology and social innovation." , startup companies emerging from MaRS had created more than 4,000 jobs, and in the period of 2011 to 2014 had raised over $750 million in capital investments. The name MaRS was originally drawn from a file name, and later attributed with the title "Medical and Related Sciences." It has since abandoned this association as it also works in other fields such as information and communications technology, engineering, and social innovation. Facilities It is located on the corner of College Street and University Avenue in the city of Toronto’s Discovery Distri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
