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Matthews Correlation Coefficient
In statistics, the phi coefficient (or mean square contingency coefficient and denoted by φ or rφ) is a measure of association for two binary variables. In machine learning, it is known as the Matthews correlation coefficient (MCC) and used as a measure of the quality of binary (two-class) Binary classification, classifications, introduced by biochemist Brian Matthews (biochemist), Brian W. Matthews in 1975. Introduced by Karl Pearson, and also known as the ''Yule phi coefficient'' from its introduction by Udny Yule in 1912 this measure is similar to the Pearson correlation coefficient in its interpretation. In fact, a Pearson correlation coefficient estimated for two binary variables will return the phi coefficient. Two binary variables are considered positively associated if most of the data falls along the diagonal cells. In contrast, two binary variables are considered negatively associated if most of the data falls off the diagonal. If we have a 2×2 table for two random varia ...
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Statistics
Statistics (from German language, German: ''wikt:Statistik#German, Statistik'', "description of a State (polity), state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of statistical survey, surveys and experimental design, experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey sample (statistics), samples. Representative sampling as ...
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False Negative
A false positive is an error in binary classification in which a test result incorrectly indicates the presence of a condition (such as a disease when the disease is not present), while a false negative is the opposite error, where the test result incorrectly indicates the absence of a condition when it is actually present. These are the two kinds of errors in a binary test, in contrast to the two kinds of correct result (a and a ). They are also known in medicine as a false positive (or false negative) diagnosis, and in statistical classification as a false positive (or false negative) error. In statistical hypothesis testing the analogous concepts are known as type I and type II errors, where a positive result corresponds to rejecting the null hypothesis, and a negative result corresponds to not rejecting the null hypothesis. The terms are often used interchangeably, but there are differences in detail and interpretation due to the differences between medical testing and statist ...
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Cramér's V (statistics)
In statistics, Cramér's V (sometimes referred to as Cramér's phi and denoted as φ''c'') is a measure of association between two nominal variables, giving a value between 0 and +1 (inclusive). It is based on Pearson's chi-squared statistic and was published by Harald Cramér in 1946. Usage and interpretation φ''c'' is the intercorrelation of two discrete variablesSheskin, David J. (1997). Handbook of Parametric and Nonparametric Statistical Procedures. Boca Raton, Fl: CRC Press. and may be used with variables having two or more levels. φ''c'' is a symmetrical measure: it does not matter which variable we place in the columns and which in the rows. Also, the order of rows/columns doesn't matter, so φ''c'' may be used with nominal data types or higher (notably, ordered or numerical). Cramér's V may also be applied to goodness of fit chi-squared models when there is a 1 × ''k'' table (in this case ''r'' = 1). In this case ''k'' is taken as the number of optional ...
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Contingency Table
In statistics, a contingency table (also known as a cross tabulation or crosstab) is a type of table in a matrix format that displays the (multivariate) frequency distribution of the variables. They are heavily used in survey research, business intelligence, engineering, and scientific research. They provide a basic picture of the interrelation between two variables and can help find interactions between them. The term ''contingency table'' was first used by Karl Pearson in "On the Theory of Contingency and Its Relation to Association and Normal Correlation", part of the ''Drapers' Company Research Memoirs Biometric Series I'' published in 1904. A crucial problem of multivariate statistics is finding the (direct-)dependence structure underlying the variables contained in high-dimensional contingency tables. If some of the conditional independences are revealed, then even the storage of the data can be done in a smarter way (see Lauritzen (2002)). In order to do this one can use ...
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Cohen's Kappa
Cohen's kappa coefficient (''κ'', lowercase Greek kappa) is a statistic that is used to measure inter-rater reliability (and also intra-rater reliability) for qualitative (categorical) items. It is generally thought to be a more robust measure than simple percent agreement calculation, as ''κ'' takes into account the possibility of the agreement occurring by chance. There is controversy surrounding Cohen's kappa due to the difficulty in interpreting indices of agreement. Some researchers have suggested that it is conceptually simpler to evaluate disagreement between items. History The first mention of a kappa-like statistic is attributed to Galton in 1892. The seminal paper introducing kappa as a new technique was published by Jacob Cohen in the journal ''Educational and Psychological Measurement'' in 1960. Definition Cohen's kappa measures the agreement between two raters who each classify ''N'' items into ''C'' mutually exclusive categories. The definition of \kappa is :\k ...
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BMC Genomics
''BMC Genomics'' is an open-access scientific journal covering all areas of genomics and proteomics. The journal was established in 2000 and is published by BioMed Central. The editor-in-chief is Matteo Pasini. Its 2021 impact factor is 4.56. Abstracting and Indexing The journal is indexed in PubMed, PubMed Central, MEDLINE, BIOSIS Previews, EMBASE, Scopus, Zoological Record ''The Zoological Record'' (''ZR'') is an electronic index of zoological literature that also serves as the unofficial register of scientific names in zoology. It was started as a print publication in 1864 by the Zoological Society of London, a ..., and other indexing services. References Genetics in the United Kingdom Genetics journals English-language journals BioMed Central academic journals Publications established in 2000 Genomics journals {{genetics-journal-stub ...
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BioData Mining
''BioData Mining'' is a peer-reviewed open access scientific journal covering data mining methods applied to computational biology and medicine established in 2008. It is published by BioMed Central and the editors-in-chief are Jason H. Moore and Marylyn D. Ritchie (University of Pennsylvania). Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 4.079. References External links *{{Official website, https://biodatamining.biomedcentral.com/ BioMed Central academic journals Biomedical informatics journals Creative Commons Attribution-licensed journals Publications established in 2008 Continuous journals ...
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Computational Biology
Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has foundations in applied mathematics, chemistry, and genetics. It differs from biological computing, a subfield of computer engineering which uses bioengineering to build computers. History Bioinformatics, the analysis of informatics processes in biological systems, began in the early 1970s. At this time, research in artificial intelligence was using network models of the human brain in order to generate new algorithms. This use of biological data pushed biological researchers to use computers to evaluate and compare large data sets in their own field. By 1982, researchers shared information via punch cards. The amount of data grew exponentially by the end of the 1980s, requiring new computational methods for quickly interpreting ...
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Informedness
Youden's J statistic (also called Youden's index) is a single statistic that captures the performance of a dichotomous diagnostic test. Informedness is its generalization to the multiclass case and estimates the probability of an informed decision. Definition Youden's ''J'' statistic is : J = \text + \text -1 with the two right-hand quantities being sensitivity and specificity. Thus the expanded formula is: : J = \frac+\frac-1 The index was suggested by W.J. Youden in 1950 as a way of summarising the performance of a diagnostic test, however the formula was earlier published in Science by C.S.Pierce in 1884. Its value ranges from -1 through 1 (inclusive), and has a zero value when a diagnostic test gives the same proportion of positive results for groups with and without the disease, i.e the test is useless. A value of 1 indicates that there are no false positives or false negatives, i.e. the test is perfect. The index gives equal weight to false positive and false negative ...
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Youden's J Statistic
Youden's J statistic (also called Youden's index) is a single statistic that captures the performance of a dichotomous diagnostic test. Informedness is its generalization to the multiclass case and estimates the probability of an informed decision. Definition Youden's ''J'' statistic is : J = \text + \text -1 with the two right-hand quantities being sensitivity and specificity. Thus the expanded formula is: : J = \frac+\frac-1 The index was suggested by W.J. Youden in 1950 as a way of summarising the performance of a diagnostic test, however the formula was earlier published in Science by C.S.Pierce in 1884. Its value ranges from -1 through 1 (inclusive), and has a zero value when a diagnostic test gives the same proportion of positive results for groups with and without the disease, i.e the test is useless. A value of 1 indicates that there are no false positives or false negatives, i.e. the test is perfect. The index gives equal weight to false positive and false negative ...
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Markedness
In linguistics and social sciences, markedness is the state of standing out as nontypical or divergent as opposed to regular or common. In a marked–unmarked relation, one term of an opposition is the broader, dominant one. The dominant default or minimum-effort form is known as ''unmarked''; the other, secondary one is ''marked''. In other words, markedness involves the characterization of a "normal" linguistic unit against one or more of its possible "irregular" forms. In linguistics, markedness can apply to, among others, Phonology, phonological, Grammar, grammatical, and Semantics, semantic oppositions, defining them in terms of marked and unmarked oppositions, such as ''honest'' (unmarked) vs. ''dishonest'' (marked). Marking may be purely semantic, or may be realized as extra morphology. The term derives from the marking of a grammatical role with a suffix or another element, and has been extended to situations where there is no morphological distinction. In social scien ...
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Dual (mathematics)
In mathematics, a duality translates concepts, theorems or mathematical structures into other concepts, theorems or structures, in a one-to-one fashion, often (but not always) by means of an involution operation: if the dual of is , then the dual of is . Such involutions sometimes have fixed points, so that the dual of is itself. For example, Desargues' theorem is self-dual in this sense under the ''standard duality in projective geometry''. In mathematical contexts, ''duality'' has numerous meanings. It has been described as "a very pervasive and important concept in (modern) mathematics" and "an important general theme that has manifestations in almost every area of mathematics". Many mathematical dualities between objects of two types correspond to pairings, bilinear functions from an object of one type and another object of the second type to some family of scalars. For instance, ''linear algebra duality'' corresponds in this way to bilinear maps from pairs of vecto ...
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