Massive Parallelism (other)
Massively parallel in computing is the use of a large number of processors to perform a set of computations in parallel (simultaneously). Massively parallel may also refer to: * Massive parallel sequencing, or massively parallel sequencing, DNA sequencing using the concept of massively parallel processing * Massively parallel signature sequencing, a procedure used to identify and quantify mRNA transcripts See also *MPQC MPQC (Massively Parallel Quantum Chemistry) is an ab initio computational chemistry software program. Three features distinguish it from other quantum chemistry programs such as Gaussian and GAMESS: it is open-source, has an object-oriented design, ...

Massively Parallel
Massively parallel is the term for using a large number of computer processors (or separate computers) to simultaneously perform a set of coordinated computations in parallel. GPUs are massively parallel architecture with tens of thousands of threads. One approach is grid computing, where the processing power of many computers in distributed, diverse administrative domains is opportunistically used whenever a computer is available.''Grid computing: experiment management, tool integration, and scientific workflows'' by Radu Prodan, Thomas Fahringer 2007 pages 1–4 An example is BOINC, a volunteer-based, opportunistic grid system, whereby the grid provides power only on a best effort basis.''Parallel and Distributed Computational Intelligence'' by Francisco Fernández de Vega 2010 pages 65–68 Another approach is grouping many processors in close proximity to each other, as in a computer cluster. In such a centralized system the speed and flexibility of the interconnect beco ...
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Massive Parallel Sequencing
Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing (NGS) or second-generation sequencing. Some of these technologies emerged between 1994 and 1998 and have been commercially available since 2005. These technologies use miniaturized and parallelized platforms for sequencing of 1 million to 43 billion short reads (50 to 400 bases each) per instrument run. Many NGS platforms differ in engineering configurations and sequencing chemistry. They share the technical paradigm of massive parallel sequencing via spatially separated, clonally amplified DNA templates or single DNA molecules in a flow cell. This design is very different from that of Sanger sequencing—also known as capillary sequencing or first-generation sequencing—which is based on electrophoretic separation of chain-termination products produced in individ ...
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Massively Parallel Signature Sequencing
Massive parallel signature sequencing (MPSS) is a procedure that is used to identify and quantify mRNA transcripts, resulting in data similar to serial analysis of gene expression (SAGE), although it employs a series of biochemical and sequencing steps that are substantially different. How it works MPSS is a method for determining expression levels of mRNA by counting the number of individual mRNA molecules produced by each gene. It is "open ended" in the sense that the identity of the RNAs to be measured are not pre-determined as they are with gene expression microarrays. A sample of mRNA are first converted to complementary DNA (cDNA) using reverse transcriptase, which makes subsequent manipulations easier. These cDNA are fused to a small oligonucleotide "tag" which allows the cDNA to be PCR amplified and then coupled to microbeads. After several rounds of sequence determination, using hybridization of fluorescent labeled probes, a sequence signature of ~16–20 bp is determ ...
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