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MYH Glycosylase
MYH can refer to: *An alternative name for MUTYH, a gene that causes colon polyps when mutated. *Muslim Youth Helpline, a charity helpline that provides support for young people in the UK. * An abbreviation for "million years hence", as a future-looking parallel to the more common ''mya'' ("million years ago"). * Myosin heavy chain {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MUTYH
''MUTYH'' (mutY DNA glycosylase) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase. It is involved in oxidative DNA damage repair and is part of the base excision repair pathway. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a common form of oxidative DNA damage. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Location and structure MUTYH has its locus on the short (p) arm of chromosome 1 (1p34.1), from base pair 45,464,007 to base pair 45,475,152 (45,794,835–45,806,142). The gene is composed of 16 exons and has a size of 546 amino acids and is approximately 7.1kb. The presence of disulfide crosslinking gives rise to a complex crystal structure of the MUTY-DNA. The protein ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Muslim Youth Helpline
Muslim Youth Helpline (MYH) is a national helpline in the UK providing free and confidential faith and culturally sensitive support services targeted at vulnerable young people. It is registered as a charitable organisation, charity. History 2001-2003: Foundation MYH was founded in August 2001 by Mohammed Sadiq Mamdani, who at the time was 18, in response to the social problems endured by Muslim youth in the UK. It was at college that Mamdani first realised the extent of isolation that today's young Muslims experience; while problems such as drug misuse, clinical depression, depression and sexuality are issues common among many young people, he believed that young Muslims often need advice that takes into account broader religious and social contexts. 2004-2006: Recognition, expansion, campaigns By 2004, MYH had expanded nationwide and was the only telephone helpline of its kind in the UK. It started running a befriending scheme through which volunteers meet up with young Musl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |