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Lumír Krejčí
Lumír Krejčí (born 30 March 1972 in Slavičín) is a Czech biochemist. His research is focused on regulatory processes involved in maintaining genome integrity. Currently, as Associate Professor in biochemistry, he leads the laboratory of recombination and DNA repair (LORD) at the Department of Biology, Faculty of Medicine, at Masaryk University in Brno. His laboratory has worked on understanding how Rad51 paralogs act during homologous recombination. At Masaryk University, Lumír Krejčí organizes Mendel Lectures, a series of lectures given by the world´s top scientists, and he is the founders of BIOSKOP - Research Education Center. Publications His most cited papers are: *Krejci L, Van Komen S, Li Y, Villemain J, Reddy MS, Klein H, Ellenberger T, Sung P. "DNA helicase Srs2 disrupts the Rad51 presynaptic filament." ''Nature''. 2003 May;423(6937):305. Cited 558 times according to Google Scholar Google Scholar author pagAccessed Sept. 22, 2019. *Papouli E, Chen S, Davies AA, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Slavičín
Slavičín () is a town in Zlín District in the Zlín Region of the Czech Republic. It has about 6,200 inhabitants. Administrative parts Villages of Divnice, Hrádek na Vlárské dráze and Nevšová are administrative parts of Slavičín. Geography Slavičín is located about southeast of Zlín. It lies in the Vizovice Highlands, on the Říka stream. History The first written mention of Slavičín is from 1141. For centuries, it was mostly an agricultural village where the craft did not flourish much. In 1860 a tannery was founded here, which was later expanded by a shoe factory. In 1936, an engineering company was established and Slavičín became an industrial village. After the World War II Slavičín further expanded, and in 1964 it became a town. Demographics Sights The cemetery Church of Saint Adalbert is the oldest building in the town. The original church was from the 13th century. After it was destroyed by a fire, it was completely rebuilt in the Baroque style in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Damage (naturally Occurring)
DNA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a nucleobase missing from the backbone of DNA, or a chemically changed base such as 8-OHdG. DNA damage can occur naturally or via environmental factors, but is distinctly different from mutation, although both are types of error in DNA. DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of base pairs. DNA damages cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. The DNA damage response (DDR) is a complex signal transduction pathway which recognizes when DNA is damaged and initiates the cellular response to the damage. DNA damage and mutation have different biological consequences. While most DNA damages can undergo DNA repair, such repair is not 100% efficient. Un-repaired DNA damages accumulate in non-replicating cells, such as cells in the brains o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1972 Births
Within the context of Coordinated Universal Time (UTC) it was the longest year ever, as two leap seconds were added during this 366-day year, an event which has not since been repeated. (If its start and end are defined using mean solar time he legal time scale its duration was 31622401.141 seconds of Terrestrial Time (or Ephemeris Time), which is slightly shorter than 1908). Events January * January 1 – Kurt Waldheim becomes Secretary-General of the United Nations. * January 4 - The first scientific hand-held calculator (HP-35) is introduced (price $395). * January 7 – Iberia Airlines Flight 602 crashes into a 462-meter peak on the island of Ibiza; 104 are killed. * January 9 – The RMS ''Queen Elizabeth'' is destroyed by fire in Hong Kong harbor. * January 10 – Independence leader Sheikh Mujibur Rahman returns to Bangladesh after spending over nine months in prison in Pakistan. * January 11 – Sheikh Mujibur Rahman declares a new constitutional governme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academic Staff Of Masaryk University
An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of secondary education, secondary or tertiary education, tertiary higher education, higher learning (and generally also research or honorary membership). The name traces back to Plato's school of philosophy, founded approximately 385 BC at Akademia, a sanctuary of Athena, the goddess of wisdom and Skills, skill, north of Ancient Athens, Athens, Greece. Etymology The word comes from the ''Academy'' in ancient Greece, which derives from the Athenian hero, ''Akademos''. Outside the city walls of Athens, the Gymnasium (ancient Greece), gymnasium was made famous by Plato as a center of learning. The sacred space, dedicated to the goddess of wisdom, Athena, had formerly been an olive Grove (nature), grove, hence the expression "the groves of Academe". In these gardens, the philosopher Plato conversed with followers. Plato developed his sessions into a method of teaching philosophy and in 3 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Czech Biochemists
Czech may refer to: * Anything from or related to the Czech Republic, a country in Europe ** Czech language ** Czechs, the people of the area ** Czech culture ** Czech cuisine * One of three mythical brothers, Lech, Czech, and Rus' Places *Czech, Łódź Voivodeship, Poland *Czechville, Wisconsin, unincorporated community, United States People * Bronisław Czech (1908–1944), Polish sportsman and artist * Danuta Czech (1922–2004), Polish Holocaust historian * Hermann Czech (born 1936), Austrian architect * Mirosław Czech (born 1968), Polish politician and journalist of Ukrainian origin * Zbigniew Czech (born 1970), Polish diplomat See also * Čech, a surname * Czech lands * Czechoslovakia * List of Czechs * * * Czechoslovak (other) * Czech Republic (other) * Czechia (other) Czechia is the official short form name of the Czech Republic. Czechia may also refer to: * Historical Czech lands *Czechoslovakia (1918–1993) *Czech Socialist Republi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclease
A nuclease (also archaically known as nucleodepolymerase or polynucleotidase) is an enzyme capable of cleaving the phosphodiester bonds between nucleotides of nucleic acids. Nucleases variously effect single and double stranded breaks in their target molecules. In living organisms, they are essential machinery for many aspects of DNA repair. Defects in certain nucleases can cause genetic instability or immunodeficiency. Nucleases are also extensively used in molecular cloning. There are two primary classifications based on the locus of activity. Exonucleases digest nucleic acids from the ends. Endonucleases act on regions in the ''middle'' of target molecules. They are further subcategorized as deoxyribonucleases and ribonucleases. The former acts on DNA, the latter on RNA. History In the late 1960s, scientists Stuart Linn and Werner Arber isolated examples of the two types of enzymes responsible for phage growth restriction in Escherichia coli ( E. coli) bacteria. One of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAD51
DNA repair protein RAD51 homolog 1 is a protein encoded by the gene ''RAD51''. The enzyme encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA and yeast Rad51. The protein is highly conserved in most eukaryotes, from yeast to humans. Variants Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. Transcript variants utilizing alternative polyA signals exist. Family In mammals, seven recA-like genes have been identified: Rad51, Rad51L1/B, Rad51L2/C, Rad51L3/D, XRCC2, XRCC3, and DMC1/Lim15. All of these proteins, with the exception of meiosis-specific DMC1, are essential for development in mammals. Rad51 is a member of thRecA-like NTPases Function In humans, RAD51 is a 339-amino acid protein that plays a major role in homologous recombination of DNA during double strand break r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proliferating Cell Nuclear Antigen
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics. Many proteins interact with PCNA via the two known PCNA-interacting motifs PCNA-interacting peptide (PIP) box and AlkB homologue 2 PCNA interacting motif (APIM). Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are mainly important in the context of genotoxic stress. Function The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAD52
RAD52 homolog (S. cerevisiae), also known as RAD52, is a protein which in humans is encoded by the ''RAD52'' gene. Function The protein encoded by this gene shares similarity with ''Saccharomyces cerevisiae'' Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51-related DNA recombination and repair. Role in DNA recombination repair RAD52 mediates RAD51 function in homologous recombinational repair (HRR) in both yeast ''Saccharomyces cerevisiae'' and in mammalian cells of mice and humans. However, the RAD52 protein has distinctly different functions in HRR of yeast and humans. In ''S. cerevisiae'', Rad52 protein, acting alone, facilitates the loading of Rad51 protein onto single-str ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SUMO Protein
In molecular biology, SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. This process is called SUMOylation (sometimes written sumoylation). SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle. SUMO proteins are similar to ubiquitin and are considered members of the ubiquitin-like protein family. SUMOylation is directed by an enzymatic cascade analogous to that involved in ubiquitination. In contrast to ubiquitin, SUMO is not used to tag proteins for degradation. Mature SUMO is produced when the last four amino acids of the C-terminus have been cleaved off to allow formation of an isopeptide bond between the C-terminal glycine residue of SUMO and an acceptor lysine on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Meiosis
Meiosis (; , since it is a reductional division) is a special type of cell division of germ cells in sexually-reproducing organisms that produces the gametes, such as sperm or egg cells. It involves two rounds of division that ultimately result in four cells with only one copy of each chromosome ( haploid). Additionally, prior to the division, genetic material from the paternal and maternal copies of each chromosome is crossed over, creating new combinations of code on each chromosome. Later on, during fertilisation, the haploid cells produced by meiosis from a male and female will fuse to create a cell with two copies of each chromosome again, the zygote. Errors in meiosis resulting in aneuploidy (an abnormal number of chromosomes) are the leading known cause of miscarriage and the most frequent genetic cause of developmental disabilities. In meiosis, DNA replication is followed by two rounds of cell division to produce four daughter cells, each with half the number of chr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome Instability
Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage. These mutations can include changes in nucleic acid sequences, chromosomal rearrangements or aneuploidy. Genome instability does occur in bacteria. In multicellular organisms genome instability is central to carcinogenesis, and in humans it is also a factor in some neurodegenerative diseases such as amyotrophic lateral sclerosis or the neuromuscular disease myotonic dystrophy. The sources of genome instability have only recently begun to be elucidated. A high frequency of externally caused DNA damage can be one source of genome instability since DNA damage can cause inaccurate translesion DNA synthesis past the damage or errors in repair, leading to mutation. Another source of genome instability may be epigenetic or mutational reductions in expression of DNA repair genes. Because endogenous (metabolically-caused) DNA damage is very fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
