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Lorenzo's Oil
''Lorenzo's Oil'' is a 1992 American drama film directed and co-written by George Miller. It is based on the true story of Augusto and Michaela Odone, parents who search for a cure for their son Lorenzo's adrenoleukodystrophy (ALD), leading to the development of Lorenzo's oil. The film was shot in Pittsburgh, Pennsylvania, primarily from September 1991 to February 1992. It had a limited release in North America on December 30, 1992, with a nationwide release two weeks later, on January 15, 1993. Though it was a box office disappointment, grossing $7.2 million against its $30 million budget, the film was generally well received by the critics and garnered two nominations at the 65th Academy Awards. Plot Lorenzo is a bright and vibrant young boy living in the Comoro Islands, as his father Augusto Odone works for the World Bank and is stationed there. However, after relocating with his parents to the United States, he begins to show signs of neurological problems (such as fa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Miller (filmmaker)
George Miller (born 3 March 1945) is an Australian filmmaker best known for his ''Mad Max'' franchise, whose second installment, ''Mad Max 2'', and fourth, ''Fury Road'', have been hailed as two of the greatest action films of all time, with ''Fury Road'' winning six Academy Awards. Miller is very diverse in genre and style as he also directed the biographical medical drama '' Lorenzo's Oil'', the dark fantasy ''The Witches of Eastwick'', the Academy Award-winning animated film '' Happy Feet,'' produced the family-friendly fantasy adventure '' Babe'' and directed the sequel '' Babe: Pig in the City.'' Miller is a co-founder of the production houses Kennedy Miller Mitchell, formerly known as Kennedy Miller, and Dr. D Studios. His younger brother Bill Miller and Doug Mitchell have been producers on almost all the films in Miller's later career, since the death of his original producing partner Byron Kennedy. In 2006, Miller won the Academy Award for Best Animated Feature f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
65th Academy Awards
The 65th Academy Awards ceremony, presented by the Academy of Motion Picture Arts and Sciences (AMPAS), honored films released in 1992 in the United States and took place on March 29, 1993, at the Dorothy Chandler Pavilion in Los Angeles beginning at 6:00 p.m. PST / 9:00 p.m. EST. During the ceremony, AMPAS presented Academy Awards (commonly referred to as Oscars) in 23 categories. The ceremony, televised in the United States by ABC, was produced by Gil Cates and directed by Jeff Margolis. Actor Billy Crystal hosted the show for the fourth consecutive year. In related events, during a ceremony held at the Century Plaza Hotel in Los Angeles on March 6, the Academy Awards for Technical Achievement were presented by host Sharon Stone. '' Unforgiven'' won four Oscars, including Best Picture. Other winners included '' Bram Stoker's Dracula'' and '' Howards End'' with three awards, ''Aladdin'' with two, and '' The Crying Game'', '' Death Becomes Her'', ''Educating ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerry Bamman
Gerald G. Bamman (born September 18, 1941) is an American actor and playwright. He is best known for playing Uncle Frank in the films ''Home Alone'' (1990) and '' Home Alone 2: Lost in New York'' (1992), and has also guest starred in several television series. Early and personal life Bamman was born on September 18, 1941 in Independence, Kansas, the son of Mary M. (née Farrell) and Harry W. Bamman. He studied at St. Francis de Sales School and later graduated from New York University with a MFA degree. Bamman was married to director Emily Mann on August 12, 1981, but is now divorced from her. They have one son, Nicholas, born in 1983. Career Bamman appeared in the Michael J. Fox film '' The Secret of My Success'' (1987) and also appeared with Fran Brill and Alyssa Milano in '' Old Enough'' (1984). He had a minor role in '' Cocktail'' (1988) before portraying his most notable character, Uncle Frank McCallister in ''Home Alone'' and '' Home Alone 2: Lost in New York'' in 19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kathleen Wilhoite
Kathleen Wilhoite (born June 29, 1964) is an American actress and musician. She made her feature film debut in '' Private School'' (1983) before having a leading role in '' Murphy's Law'' (1986), followed by supporting parts in ''Witchboard'' (also 1986), ''Crossing Delancey'' (1988), '' Road House'' (1989), and '' Lorenzo's Oil'' (1992). She also had notable guest-starring roles on several series during this time, including '' Twin Peaks'' (1990). Beginning in 1994, Wilhoite appeared as Chloe Lewis in a recurring guest-starring role on the series '' ER'', and voiced the role of the titular character on the ABC animated series ''Pepper Ann'' (1997–2000). Other notable film roles during the 1990s include the science fiction thriller ''Fire in the Sky'' (1993), and the survival film '' The Edge'' (1997). In 2003, she was cast in a recurring role as Liz Danes on ''Gilmore Girls'', and has subsequently had guest-starring roles on ''Criminal Minds'' (2008), '' Grey's Anatomy'' (200 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hugo Moser (scientist)
Hugo Wolfgang Moser (1924–2007), was a Swiss-born American research scientist and director of the Neurogenetics Research Center at the Kennedy Krieger Institute. Moser was also University Professor of Neurology and Pediatrics at Johns Hopkins University. His research on peroxisomal disorders achieved international recognition. Early life Moser was born in Bern, Switzerland, the son of Maria and Hugo L. Moser. He grew up in Berlin. His father was of Jewish background and a prominent art dealer in Berlin. His mother was Austrian. Within a month of Hitler taking power in Germany the family left Berlin. Hugo spent his high school years in the Netherlands. Three months prior to the invasion of the Netherlands his mother arranged their timely escape from the Nazis. The family fled via Italy and Spain to Cuba. In 1940, the family arrived in the US, first living in Baltimore, where the family owned paintings exhibited in the Baltimore Museum of Art, then moved to New York City. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Myelin Project
The Myelin Project is 501(c)(3) nonprofit organization established in 1989 by Augusto Odone and his wife, Michaela. Their son, Lorenzo, suffered from adrenoleukodystrophy (ALD), the most common of the leukodystrophies. The story of the Odones' struggle was dramatized in the 1992 film '' Lorenzo's Oil''. The Myelin Project has three branches in the United States, Germany, and the United Kingdom. The Myelin Project's scientific advisory committee includes researchers from Yale University and the University of Wisconsin–Madison in the United States, the Istituto Superiore di Sanità and San Raffaele Hospital in Italy, the Hôpital de la Salpêtrière and the Institute Pasteur in France, Queen's University at Kingston in Canada, the University of Cambridge and University of Edinburgh in the United Kingdom, and the Max-Planck-Institut in Germany. The project's aims The Myelin Project aims to advance research, advocacy, and family support for ALD and adrenomyeloneuropathy (A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lipid
Lipids are a broad group of naturally-occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes. Lipids have applications in the cosmetic and food industries, and in nanotechnology. Lipids may be broadly defined as hydrophobic or amphiphilic small molecules; the amphiphilic nature of some lipids allows them to form structures such as vesicles, multilamellar/ unilamellar liposomes, or membranes in an aqueous environment. Biological lipids originate entirely or in part from two distinct types of biochemical subunits or "building-blocks": ketoacyl and isoprene groups. Using this approach, lipids may be divided into eight categories: fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, saccharolipids, and polyketides (derived ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myelin Sheath
Myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system's "wires") to insulate them and increase the rate at which electrical impulses (called action potentials) are passed along the axon. The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However, unlike the plastic covering on an electrical wire, myelin does not form a single long sheath over the entire length of the axon. Rather, myelin sheaths the nerve in segments: in general, each axon is encased with multiple long myelinated sections with short gaps in between called nodes of Ranvier. Myelin is formed in the central nervous system (CNS; brain, spinal cord and optic nerve) by glial cells called oligodendrocytes and in the peripheral nervous system (PNS) by glial cells called Schwann cells. In the CNS, axons carry electrical signals from one nerve cell body to another. In the PNS, axons carry signals to muscles and glands or from sensor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Olive Oil
Olive oil is a liquid fat obtained from olives (the fruit of ''Olea europaea''; family Oleaceae), a traditional tree crop of the Mediterranean Basin, produced by pressing whole olives and extracting the oil. It is commonly used in cooking: for frying foods or as a salad dressing. It can be found in some cosmetics, pharmaceuticals, soaps, and fuels for traditional oil lamps. It also has additional uses in some religions. The olive is one of three core food plants in Mediterranean cuisine; the other two are wheat and grapes. Olive trees have been grown around the Mediterranean since the 8th millennium BC. In 2019–2020, world production of olive oil was . Spain was the largest producer followed by Italy, Tunisia, Greece, Turkey and Morocco. San Marino has by far the largest per capita consumption of olive oil worldwide. The composition of olive oil varies with the cultivar, altitude, time of harvest, and extraction process. It consists mainly of oleic acid (up to 83%), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rapeseed Oil
Close-up of canola blooms Canola flower Rapeseed oil is one of the oldest known vegetable oils. There are both edible and industrial forms produced from rapeseed, the seed of several cultivars of the plant family Brassicaceae. Historically, it was eaten in limited quantities due to high levels of erucic acid, which is damaging to the cardiac muscle of animals and imparts a bitter taste, and glucosinolates, which made it less nutritious in animal feed. Rapeseed oil can contain up to 54% erucic acid. Canola oil is a food-grade version derived from rapeseed cultivars bred for low erucic acid content. Also known as low erucic acid rapeseed (LEAR) oil, it has been generally recognized as safe by the United States Food and Drug Administration. Canola oil is limited by government regulation to a maximum of 2% erucic acid by weight in the US and the EU, with special regulations for infant food. These low levels of erucic acid do not cause harm in humans. In commerce, non-food ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Long Chain Fatty Acids
In chemistry, particularly in biochemistry, a fatty acid is a carboxylic acid with an aliphatic chain, which is either saturated or unsaturated. Most naturally occurring fatty acids have an unbranched chain of an even number of carbon atoms, from 4 to 28. Fatty acids are a major component of the lipids (up to 70% by weight) in some species such as microalgae but in some other organisms are not found in their standalone form, but instead exist as three main classes of esters: triglycerides, phospholipids, and cholesteryl esters. In any of these forms, fatty acids are both important dietary sources of fuel for animals and important structural components for cells. History The concept of fatty acid (''acide gras'') was introduced in 1813 by Michel Eugène Chevreul, though he initially used some variant terms: ''graisse acide'' and ''acide huileux'' ("acid fat" and "oily acid"). Types of fatty acids Fatty acids are classified in many ways: by length, by saturation vs unsaturati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Croda International
Croda International plc is a British speciality chemicals company based at Snaith, England. It is listed on the London Stock Exchange. History The company was founded by George William Crowe and Henry James Dawe in 1925. Crowe bought an abandoned waterworks facility at Rawcliffe Bridge for £7, which would later be used to manufacture the company's first barrels of lanolin, a natural protective fat present in sheep's wool. The company was named ''Croda (''a combination of the first few letters of his surname with that of his partner, Dawe). Crowe and Dawe began working on a process to extract lanolin from sheep’s wool for various industries, including uses in cosmetics, as a waterproofing agent, and as a dressing for leather. At the time, the UK imported lanolin, having no domestic lanolin production at all. Dawe's extraction process failed initially and Dawe left the company. Philip Wood, Crowe's nephew, was appointed manager of the site in 1925, and Wood worked closely ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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