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List Of Life Extension Topics
The following Outline (list), outline is provided as an overview of and topical guide to life extension: Life extension – study of slowing down or reversing the senescence, processes of aging to extend both the maximum lifespan, maximum and life expectancy, average lifespan. Also known as anti-aging medicine, experimental gerontology, and biomedical gerontology. Goals * Biological immortality * Indefinite lifespan * Longevity * Rejuvenation (aging), Rejuvenation Longevity * Centenarian * Supercentenarian * Longevity escape velocity Strategies Research and development * Timeline of senescence research Available strategies * Calorie restriction or protein restriction or intermittent fasting * Physical exercise, Exercise * Geroprotector * Senolytics Potential future strategies * Cryonics * Life extension#Chemical and genetic interventions in animal models, Genetic therapies ** Life extension#Cloning and body part replacement, Cloning and body part replac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intermittent Fasting
Intermittent fasting is any of various meal timing schedules that cycle between voluntary fasting (or reduced calorie intake) and non-fasting over a given period. Methods of intermittent fasting include alternate-day fasting, periodic fasting, and daily time-restricted feeding. Intermittent fasting has been studied to find whether it can reduce the risk of diet-related diseases, such as metabolic syndrome. A 2019 review concluded that intermittent fasting may help with obesity, insulin resistance, dyslipidemia, hypertension, and inflammation. A 2022 review indicated that intermittent fasting is generally safe. Adverse effects of intermittent fasting have not been comprehensively studied, leading some academics to point out its risk as a dietary fad. The US National Institute on Aging states that there is insufficient evidence to recommend intermittent fasting, and encourages speaking to one's healthcare provider about the benefits and risks before making any significant changes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pro-aging Trance
Pro-aging trance, also known as pro-aging edifice, is a term coined by British author and biomedical gerontologist Aubrey de Grey to describe the broadly positive and fatalistic attitude toward aging in society. Overview According to de Grey, the pro-aging trance explains why many people gloss over aging through irrational thought patterns. The concept says that the thought of one's own body slowly but ceaselessly deteriorating is so burdensome that it seems most sensible from a psychological point of view to try to put it out of one's mind. Since aging has been present throughout human history, this coping strategy would be deeply rooted in human thinking. It is striking that, in defending their point of view, those affected often commit fallacies which, from experience, would not be expected of them in a different context. The name, according to de Grey, comes from the similarity of persons affected to hypnotized people, whose subconscious minds in the trance state prefer to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gerontology
Gerontology ( ) is the study of the social, cultural, psychological, cognitive, and biological aspects of aging. The word was coined by Ilya Ilyich Mechnikov in 1903, from the Greek , ''geron'', "old man" and , ''-logia'', "study of". The field is distinguished from geriatrics, which is the branch of medicine that specializes in the treatment of existing disease in older adults. Gerontologists include researchers and practitioners in the fields of biology, nursing, medicine, criminology, dentistry, social work, physical and occupational therapy, psychology, psychiatry, sociology, economics, political science, architecture, geography, pharmacy, public health, housing, and anthropology. The multidisciplinary nature of gerontology means that there are a number of sub-fields which overlap with gerontology. There are policy issues, for example, involved in government planning and the operation of nursing homes, investigating the effects of an aging population on society, and the de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evolution Of Ageing
Enquiry into the evolution of ageing, or aging, aims to explain why a detrimental process such as ageing would evolve, and why there is so much variability in the lifespans of organisms. The classical theories of evolution (mutation accumulation, antagonistic pleiotropy, and disposable soma) suggest that environmental factors, such as predation, accidents, disease, starvation, ensure that most organisms living in natural settings will not live until old age, and so there will be very little pressure to conserve genetic changes that increase longevity. Natural selection will instead strongly favor genes which ensure early maturation and rapid reproduction, and the selection for genetic traits which promote molecular and cellular self-maintenance will decline with age for most organisms. Theories and hypotheses The beginning August Weismann was responsible for interpreting and formalizing the mechanisms of Darwinian evolution in a modern theoretical framework. In 1889, he theor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immunisation
Immunization, or immunisation, is the process by which an individual's immune system becomes fortified against an infectious agent (known as the immunogen). When this system is exposed to molecules that are foreign to the body, called ''non-self'', it will orchestrate an immune response, and it will also develop the ability to quickly respond to a subsequent encounter because of immunological memory. This is a function of the adaptive immune system. Therefore, by exposing a human, or an animal, to an immunogen in a controlled way, its body can learn to protect itself: this is called active immunization. The most important elements of the immune system that are improved by immunization are the T cells, B cells, and the antibodies B cells produce. Memory B cells and memory T cells are responsible for a swift response to a second encounter with a foreign molecule. Passive immunization is direct introduction of these elements into the body, instead of production of these elements ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suspended Animation
Suspended animation is the temporary (short- or long-term) slowing or stopping of biological function so that physiological capabilities are preserved. It may be either hypometabolic or ametabolic in nature. It may be induced by either endogenous, natural or artificial biological, chemical or physical means. In its natural form it may be spontaneously reversible as in the case of species demonstrating hypometabolic states of hibernation or require technologically mediated revival when applied with therapeutic intent in the medical setting as in the case of deep hypothermic circulatory arrest (DHCA). Basic principles Suspended animation is understood as the pausing of life processes by exogenous or endogenous means without terminating life itself. Breathing, heartbeat and other involuntary functions may still occur, but they can only be detected by artificial means. For this reason, this procedure has been associated with a lethargic state in nature when animals or plants app ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mind Uploading
Mind uploading is a speculative process of whole brain emulation in which a brain scan is used to completely emulate the mental state of the individual in a digital computer. The computer would then run a simulation of the brain's information processing, such that it would respond in essentially the same way as the original brain and experience having a sentient conscious mind. Substantial mainstream research in related areas is being conducted in animal brain mapping and simulation, development of faster supercomputers, virtual reality, brain–computer interfaces, connectomics, and information extraction from dynamically functioning brains. According to supporters, many of the tools and ideas needed to achieve mind uploading already exist or are currently under active development; however, they will admit that others are, as yet, very speculative, but say they are still in the realm of engineering possibility. Mind uploading may potentially be accomplished by either of two m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Digital Immortality
Digital immortality (or "virtual immortality") is the hypothetical concept of storing (or transferring) a person's personality in digital substrate, i.e., a computer, robot or cyberspace (mind uploading). The result might look like an avatar behaving, reacting, and thinking like a person on the basis of that person's digital archive. After the death of the individual, this avatar could remain static or continue to learn and self-improve autonomously (possibly becoming seed AI). A considerable portion of transhumanists and singularitarians place great hope into the belief that they may eventually become immortal by creating one or many non-biological functional copies of their brains, thereby leaving their "biological shell". These copies may then "live eternally" in a version of digital "heaven" or paradise. Realism The National Science Foundation has awarded a half-million-dollar grant to the universities of Central Florida at Orlando and Illinois at Chicago to explore how r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strategies For Engineered Negligible Senescence
Strategies for engineered negligible senescence (SENS) is a range of proposed regenerative medical therapies, either planned or currently in development, for the periodic repair of all age-related damage to human tissue. These therapies have the ultimate aim of maintaining a state of negligible senescence in patients and postponing age-associated disease.de Grey, Aubrey; Rae, Michael (September 2007). ''Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime''. New York, NY: St. Martin's Press, 416 pp. . SENS was first defined by British biogerontologist Aubrey de Grey. While some biogerontologists support the SENS program, others contend that the ultimate goals of de Grey's programme are too speculative given the current state of technology. The 31-member Research Advisory Board of de Grey's SENS Research Foundation have signed an endorsement of the plausibility of the SENS approach. Framework The term "negligible senescence" was first used ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Replacement Therapy
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. , the only established therapy using stem cells is hematopoietic stem cell transplantation. This usually takes the form of a bone marrow, bone-marrow transplantation, but the cells can also be derived from umbilical cord blood. Research is underway to develop various sources for stem cells as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart disease. Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion debate, abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial. Medic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cryonics
Cryonics (from el, κρύος ''kryos'' meaning 'cold') is the low-temperature freezing (usually at ) and storage of human remains, with the speculative hope that resurrection may be possible in the future. Cryonics is regarded with skepticism within the mainstream scientific community. It is generally viewed as a pseudoscience, and its practice has been characterized as quackery. Cryonics procedures can begin only after the "patients" are clinically and legally dead. Cryonics procedures may begin within minutes of death, and use cryoprotectants to prevent ice formation during cryopreservation. It is, however, not possible for a corpse to be reanimated after undergoing vitrification, as this causes damage to the brain including its neural circuits. The first corpse to be frozen was that of James Bedford in 1967. As of 2014, about 250 dead bodies had been cryopreserved in the United States, and 1,500 people had made arrangements for cryopreservation of their corpses. Critics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
