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List Of A1 Genes, Proteins Or Receptors
This is a list of genes, proteins or receptors named A1 or Alpha-1 : * Actin, alpha 1 * Actinin, alpha 1 * Adaptor-related protein complex 2, alpha 1 * Aldehyde dehydrogenase 3 family, member A1 * Aldehyde dehydrogenase 4 family, member A1 * Aldehyde dehydrogenase 5 family, member A1 * Aldehyde dehydrogenase 6 family, member A1 * Aldehyde dehydrogenase 9 family, member A1 * Aldehyde dehydrogenase 18 family, member A1 * Aldo-keto reductase family 1, member A1 * Alpha-1-microglobulin/bikunin precursor * Apolipoprotein A1 and ApoA-1 Milano * ATPase, H+ transporting, lysosomal V0 subunit a1 * ATPase, Na+/K+ transporting, alpha 1 * ATP synthase, H+ transporting, mitochondrial F1 complex, alpha 1 * BCL2-related protein A1 * Butyrophilin, subfamily 1, member A1 * Butyrophilin, subfamily 3, member A1 * Capping protein (actin filament) muscle Z-line, alpha 1 * Carboxypeptidase A1 * Casein kinase 1, alpha 1 * Casein kinase 2, alpha 1 * Catenin (cadherin-associated protein), ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actin, Alpha 1
Actin, alpha skeletal muscle is a protein that in humans is encoded by the ''ACTA1'' gene. Actin alpha 1 which is expressed in skeletal muscle is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus. Skeletal actin gene expression Skeletal alpha actin expression is induced by stimuli and conditions known to cause muscle formation. Such conditions result in fusion of committed cells (satellite cells) into myotubes, to form muscle fibers. Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation. One key transcription factor that activates skeletal actin gene expression is Serum Response Factor ("SRF"), a protein that binds to specific sites on the promoter DNA of the actin gene. SRF may bring a number of other proteins to the promoter of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Butyrophilin, Subfamily 1, Member A1
Butyrophilin subfamily 1 member A1 is a protein that in humans is encoded by the ''BTN1A1'' gene. Butyrophilin (BTN) is the major protein associated with fat droplets in the milk. It is a member of the immunoglobulin superfamily. It may have a cell surface receptor function. The human butyrophilin gene is localized in the major histocompatibility complex (MHC) class I region of 6p and may have arisen relatively recently in evolution by the shuffling of exons between 2 ancestral gene families Function Btn1a1 regulates the amount of lipids and size of droplets expressed in milk. When the gene is compromised in laboratory mice, approximately half the pups died within the first 20 days and the remainder were significantly under-weight. Link to multiple sclerosis Butyrophilin has been presented as a potential antigen which may be similar enough to myelin oligodendrocyte glycoprotein Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein believed to be important in the myelin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collagen, Type IV, Alpha 1
Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the ''COL4A1'' gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis. Mutations in the gene have been linked to diseases of the brain, muscle, kidney, eye, and cardiovascular system. The ''COL4A1'' gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. Structure Gene The ''COL4A1'' gene resides on chromosome 13 at the band 13q34 and contains 54 exons. This gene produces 2 isoforms through alternative splicing. Protein COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S domain at its center, and a non-collagenous 1 (NC1) domain at its C-terminal. The triple-helical domain contains interrupted G-X-Y repeats, which is suspected to allow flexibility of the domain. The NC1 domain is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collagen, Type III, Alpha 1
Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (monomers), each called an alpha 1 chain of type III collagen. Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded by the gene. Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain. Protein structure and function Type III collagen is synthesized by cells as a pre-procollagen. The signal peptide is cleaved off producing a procollagen molecule. Three identical type III procollagen chains come together at the carboxy-terminal ends, and the structure is stabilized by the formation of disulphide bonds. Each individual chain folds into left-handed helix and the three chains are then wrapped together into a right-handed superhelix, the triple helix. Prior to assembling the super-helix, each monomer is subjected to a number of post-translational modifications that occur while the monomer is b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collagen, Type II, Alpha 1
Collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital), also known as COL2A1, is a human gene that provides instructions for the production of the pro-alpha1(II) chain of type II collagen. Function This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. Type II collagen, which adds structure and strength to connective tissues, is found primarily in cartilage, the jelly-like substance that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Collagen, Type I, Alpha 1
Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the gene. ''COL1A1'' encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. Function Collagen is a protein that strengthens and supports many tissues in the body, including cartilage, bone, tendon, skin and the white part of the eye (sclera). The gene produces a component of type I collagen, called the pro-alpha1(I) chain. This chain combines with another pro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by the gene) to make a molecule of type I procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong mature type I collagen fibers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coagulation Factor XIII, A1 Polypeptide
Coagulation factor XIII A chain is a protein that in humans is encoded by the ''F13A1'' gene. Function This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cholinergic Receptor, Nicotinic, Alpha 1
Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the ''CHRNA1'' gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR). The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetylcholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. Interactions Cholinergic receptor, nicotinic, alpha 1 has been shown to interact with CHRND. See also * Nicotinic acetylcholine receptor Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral ner ... References Further reading ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Centaurin, Alpha 1
Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ''ADAP1'' gene. Interactions Centaurin, alpha 1 has been shown to interact with: * Casein kinase 1, alpha 1 * Nucleolin, * P110α, * PRKCI, * Protein kinase D1, and * Protein kinase Mζ. Model organisms Model organisms have been used in the study of ADAP1 function. A conditional knockout mouse line called ''Adap1tm1a(EUCOMM)Wtsi'' was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological proper ... to determine the effects of deletion. Additional screens performed: * In-depth immunological phenotyping * in-depth bone and cartilage phenotyping References Further reading ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catenin (cadherin-associated Protein), Alpha 1
αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the ''CTNNA1'' gene. αE-catenin is highly expressed in cardiac muscle and localizes to adherens junctions at intercalated disc structures where it functions to mediate the anchorage of ACTC1, actin filaments to the sarcolemma. αE-catenin also plays a role in tumor metastasis and skin cell function. Structure Human αE-catenin protein is 100.0 kDa and 906 amino acids. Catenins (α,β,and γ (also known as plakoglobin)) were originally identified in complex with E-cadherin, an epithelium, epithelial cell adhesion protein. αE-catenin is highly expressed in cardiac muscle and is homologous to the protein vinculin; however, aside from vinculin, αE-catenin has no homology to established ACTC1, actin-binding proteins. The N-terminus of αE-catenin binds β-catenin or γ-catenin/plakoglobin, and the C-terminus binds ACTC1, actin directly or indirectly via vinculin or Actinin, alpha 2, α-actinin. Fun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Casein Kinase 2, Alpha 1
Casein kinase II subunit alpha is an enzyme that in humans is encoded by the ''CSNK2A1'' gene. Casein kinase II is a Serine/threonine-specific protein kinase, serine/threonine protein kinase that Phosphorylation, phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. Interactions Casein kinase 2, alpha 1 has been shown to Protein-protein interaction, interact with: * APC (gene), APC, * ATF1, * Activating transcription factor 2, ATF2, * C-Fos, * C-jun, * CDC25B, * CHEK1, * CREB-binding protein, CREBBP, * CSNK2B, * DNA damage-i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Casein Kinase 1, Alpha 1
Casein kinase I isoform alpha is an enzyme that in humans is encoded by the ''CSNK1A1'' gene. Interactions Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1 and AXIN1. See also * Casein kinase 1 The Casein kinase 1 family () of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo ... References Further reading * * {{gene-5-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |