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Mediator
Mediator may refer to: *A person who engages in mediation *Business mediator, a mediator in business * Vanishing mediator, a philosophical concept * Mediator variable, in statistics Chemistry and biology *Mediator (coactivator), a multiprotein complex that functions as a transcriptional coactivator * Endogenous mediator, proteins that enhance and activate the functions of other proteins * Gaseous mediator, chemicals produced by some cells that have biological signalling functions *Mediator, a brand name of benfluorex, a withdrawn appetite suppressant medication Internet, software, and computer *Mediator pattern, in computer science *A mail server's role in email forwarding Other *Mediator, guitar pick or plectrum, an accessory for picking strings of musical instruments *''The Mediator'', a teen book series by Meg Cabot (some under the pseudonym Jenny Carroll) *''The Mediator'', a television documentary produced by Open Media * Mediator (Christ as Mediator), an office of Jesu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mediator (coactivator)
Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in 1990 in the lab of Roger D. Kornberg, recipient of the 2006 Nobel Prize in Chemistry. Mediator complexes interact with transcription factors and RNA polymerase II. The main function of mediator complexes is to transmit signals from the transcription factors to the polymerase. Mediator complexes are variable at the evolutionary, compositional and conformational levels. The first image shows only one "snapshot" of what a particular mediator complex might be composed of, but it certainly does not accurately depict the conformation of the complex ''in vivo''. During evolution, mediator has become more complex. The yeast ''Saccharomyces cerevisiae'' (a simple eukaryote) is thought to have up to 21 subunits in the core mediator (exclusive of the CDK module), while mammals have up to 26. Individual subunits can be absent or replaced by other subunits under differen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Endogenous Mediator
Mediator is a multiprotein complex that functions as a transcriptional coactivator in all eukaryotes. It was discovered in 1990 in the lab of Roger D. Kornberg, recipient of the 2006 Nobel Prize in Chemistry. Mediator complexes interact with transcription factors and RNA polymerase II. The main function of mediator complexes is to transmit signals from the transcription factors to the polymerase. Mediator complexes are variable at the evolutionary, compositional and conformational levels. The first image shows only one "snapshot" of what a particular mediator complex might be composed of, but it certainly does not accurately depict the conformation of the complex ''in vivo''. During evolution, mediator has become more complex. The yeast ''Saccharomyces cerevisiae'' (a simple eukaryote) is thought to have up to 21 subunits in the core mediator (exclusive of the CDK module), while mammals have up to 26. Individual subunits can be absent or replaced by other subunits under differen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mediator Pattern
In software engineering, the mediator pattern defines an object that encapsulates how a set of objects interact. This pattern is considered to be a behavioral pattern due to the way it can alter the program's running behavior. In object-oriented programming, programs often consist of many classes. Business logic and computation are distributed among these classes. However, as more classes are added to a program, especially during maintenance and/or refactoring, the problem of communication between these classes may become more complex. This makes the program harder to read and maintain. Furthermore, it can become difficult to change the program, since any change may affect code in several other classes. With the mediator pattern, communication between objects is encapsulated within a mediator object. Objects no longer communicate directly with each other, but instead communicate through the mediator. This reduces the dependencies between communicating objects, thereby reducing co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mediation
Mediation is a structured, interactive process where an impartial third party neutral assists disputing parties in resolving conflict through the use of specialized communication and negotiation techniques. All participants in mediation are encouraged to actively participate in the process. Mediation is a "party-centered" process in that it is focused primarily upon the needs, rights, and interests of the parties. The mediator uses a wide variety of techniques to guide the process in a constructive direction and to help the parties find their optimal solution. A mediator is facilitative in that she/he manages the interaction between parties and facilitates open communication. Mediation is also evaluative in that the mediator analyzes issues and relevant norms ("reality-testing"), while refraining from providing prescriptive advice to the parties (e.g., "You should do..."). Mediation, as used in law, is a form of alternative dispute resolution resolving disputes between two o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mediation
Mediation is a structured, interactive process where an impartial third party neutral assists disputing parties in resolving conflict through the use of specialized communication and negotiation techniques. All participants in mediation are encouraged to actively participate in the process. Mediation is a "party-centered" process in that it is focused primarily upon the needs, rights, and interests of the parties. The mediator uses a wide variety of techniques to guide the process in a constructive direction and to help the parties find their optimal solution. A mediator is facilitative in that she/he manages the interaction between parties and facilitates open communication. Mediation is also evaluative in that the mediator analyzes issues and relevant norms ("reality-testing"), while refraining from providing prescriptive advice to the parties (e.g., "You should do..."). Mediation, as used in law, is a form of alternative dispute resolution resolving disputes between two o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Business Mediator
Mediation is a structured, interactive process where an impartial third party neutral assists disputing parties in resolving conflict through the use of specialized communication and negotiation techniques. All participants in mediation are encouraged to actively participate in the process. Mediation is a "party-centered" process in that it is focused primarily upon the needs, rights, and interests of the parties. The mediator uses a wide variety of techniques to guide the process in a constructive direction and to help the parties find their optimal solution. A mediator is facilitative in that she/he manages the interaction between parties and facilitates open communication. Mediation is also evaluative in that the mediator analyzes issues and relevant norms ("reality-testing"), while refraining from providing prescriptive advice to the parties (e.g., "You should do..."). Mediation, as used in law, is a form of alternative dispute resolution resolving disputes between two or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
USS Mediator
Mediator may refer to: *A person who engages in mediation *Business mediator, a mediator in business * Vanishing mediator, a philosophical concept * Mediator variable, in statistics Chemistry and biology *Mediator (coactivator), a multiprotein complex that functions as a transcriptional coactivator *Endogenous mediator, proteins that enhance and activate the functions of other proteins * Gaseous mediator, chemicals produced by some cells that have biological signalling functions *Mediator, a brand name of benfluorex, a withdrawn appetite suppressant medication Internet, software, and computer *Mediator pattern, in computer science *A mail server's role in email forwarding Other *Mediator, guitar pick or plectrum, an accessory for picking strings of musical instruments *''The Mediator'', a teen book series by Meg Cabot (some under the pseudonym Jenny Carroll) *''The Mediator'', a television documentary produced by Open Media * Mediator (Christ as Mediator), an office of Jesus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linesman/Mediator
Linesman/Mediator was a dual-purpose civil and military radar network in the United Kingdom between the 1960s and 1984. The military side (Linesman) was replaced by the Improved United Kingdom Air Defence Ground Environment (IUKADGE), while the civilian side (Mediator) became the modern public-private National Air Traffic Services (NATS). In the 1950s, the Royal Air Force was installing a radar network known as ROTOR using war-era radars like Chain Home along with new command centres. A new radar, the AMES Type 80, replaced all of the ROTOR radars and command centres with a series of nine Master Control Radars and a number of associated secondary radars. While these installations were in progress in the early 1950s, Compagnie générale de la télégraphie sans fil, CSF introduced the carcinotron, which could output a radio signal at any desired frequency. This made it a very effective Radar jamming and deception, jamming system, and it appeared to render ground-based radars li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Mediator
''The Mediator'' is a series which contains six novels written by Meg Cabot. The first four novels were originally published under Cabot's pseudonym Jenny Carroll by Simon & Schuster. The last two books were published by HarperCollins and under Meg Cabot's name. This book is romance–fiction for teenagers and young adults. Cabot stated that she originally planned the series as an eight-book arc, but because of poor sales only got the chance to write six. In several posts on her blog and forums she stated that she has the plot of an "epilogue/sequel" on file, and needs only the time to write it out. The sequel was announced on her blog, detailing that Susannah and Jesse are now engaged and that the book will be an adult installment as opposed to Young Adult, titled ''Remembrance'' and is to be released in 2015 to commemorate ''Shadowland'' or ''Love You to Death''s 15th Anniversary. The official publication date for the United States and Canada is February 14, 2016. Backgro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benfluorex
Benfluorex, sold under the brand name Mediator, is an anorectic and hypolipidemic agent that is structurally related to fenfluramine (a substituted amphetamine). It may improve glycemic control and decrease insulin resistance in people with poorly controlled type-2 diabetes. It was on the market between 1976 and 2009, and is thought to have caused between 500 and 2,000 deaths. It was patented and manufactured by the French pharmaceutical company Servier. However, Servier is suspected of having marketed benfluorex at odds with the drug's medical properties. On March 29, 2021, a French court fined Servier €2.7m (£2.3m) after finding it guilty of deception and manslaughter. Drug withdrawn On 18 December 2009, the European Medicines Agency recommended the withdrawal of all medicines containing benfluorex in the European Union, because their risks, particularly the risk of heart valve disease (fenfluramine-like cardiovascular side effects), are greater than their benefits. Thus F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HMS Mediator
Three ships of the Royal Navy have borne the name HMS ''Mediator'': * was a 10-gun sloop purchased in 1745 and captured that year by a French privateer. * was a 44-gun fifth rate launched 1782. She became the storeship HMS ''Camel'' in 1788, and was broken up in 1810. * HMS ''Mediator'' was a 44-gun fifth rate, previously the merchant ''Ann & Amelia''. She was purchased in 1804, converted to a fireship in 1809, and expended that year in the Battle of the Basque Roads The Battle of the Basque Roads, also known as the Battle of Aix Roads ( French: ''Bataille de l'île d'Aix'', also ''Affaire des brûlots'', rarely ''Bataille de la rade des Basques''), was a major naval battle of the Napoleonic Wars, fought in t .... {{DEFAULTSORT:Mediator, Hms Royal Navy ship names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mediator Variable
In statistics, a mediation model seeks to identify and explain the mechanism or process that underlies an observed relationship between an independent variable and a dependent variable via the inclusion of a third hypothetical variable, known as a mediator variable (also a mediating variable, intermediary variable, or intervening variable). Rather than a direct causal relationship between the independent variable and the dependent variable, a mediation model proposes that the independent variable influences the mediator variable, which in turn influences the dependent variable. Thus, the mediator variable serves to clarify the nature of the relationship between the independent and dependent variables. Mediation analyses are employed to understand a known relationship by exploring the underlying mechanism or process by which one variable influences another variable through a mediator variable.Cohen, J.; Cohen, P.; West, S. G.; Aiken, L. S. (2003) ''Applied multiple regression/cor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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